Benzisoxazole Hsp90 inhibitor - ≥98%, high purity , CAS No.1012788-65-6

Item Number

B339325

• Synonyms: 1012788-65-6|Benzisoxazole Hsp90 Inhibitor|CAY10607|4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol|CHEMBL404630|CHEBI:90529|4-chloro-6-(5-{[2-(morpholin-4-yl)ethyl]amino}-1,2-benzoxazol-3-yl)benzene-1,3-diol|4-chloro-6
• Specifications & Purity: ≥98%
• Storage Temp: Store at -20°C
• Shipped In: Dry ice

Product Description

Heat shock protein 90 (Hsp90) is a molecular chaperone that modulates intracellular signaling and protein folding, trafficking, and turnover. Inhibitors of Hsp90, such as geldanamycin, have shown potential as anti-tumor agents. Benzisoxazole Hsp90 Inhibitor binds the N-terminal domain of Hsp90, efficiently displacing geldanamycin from the ATP binding site (IC|50|= 30 nM). It also inhibits the proliferation of several cancer cell lines (IC|50|~ 0.28 μM), promotes the degradation of the Hsp90 client proteins Her-2 and androgen receptor, and has no effect on a variety of kinases.