Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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B133189-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $19.90 | |
B133189-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $80.90 | |
B133189-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $178.90 |
Synonyms | AS-68694 | benznidazole (TN) | Benznidazole [INN] | Radanil (TN) | Z2044771577 | Acetamide, N-benzyl-2-(nitroimidazol-1-yl)- | Benznidazole (USAN/INN) | DB11989 | FT-0662547 | Ro 07-1051;Ro 71051 | BENZNIDAZOLE [MART.] | Benznidazolum | N-benzyl-2-(2-nitr |
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Specifications & Purity | ≥97% |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
ALogP | 0.9 |
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IUPAC Name | N-benzyl-2-(2-nitroimidazol-1-yl)acetamide |
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INCHI | InChI=1S/C12H12N4O3/c17-11(14-8-10-4-2-1-3-5-10)9-15-7-6-13-12(15)16(18)19/h1-7H,8-9H2,(H,14,17) |
InChi Key | CULUWZNBISUWAS-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C(C=C1)CNC(=O)CN2C=CN=C2[N+](=O)[O-] |
Isomeric SMILES | C1=CC=C(C=C1)CNC(=O)CN2C=CN=C2[N+](=O)[O-] |
WGK Germany | 3 |
RTECS | NI3340000 |
PubChem CID | 31593 |
Molecular Weight | 260.25 |
Enter Lot Number to search for COA:
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | NI3340000 |
1. Lívia C L Sá-Barreto,Pricila C Gustmann,Felipe S Garcia,Flávia P Maximiano,Kátia M Novack,Marcílio S S Cunha-Filho. (2011-12-28) Modulated dissolution rate from the inclusion complex of antichagasic benznidazole and cyclodextrin using hydrophilic polymer.. Pharmaceutical development and technology, 18 ((5)): (1035-1041). [PMID:22200091] |
2. Miriam Navarro,Francesca F Norman,José Antonio Pérez-Molina,Rogelio López-Vélez. (2012-07-25) Benznidazole shortage makes chagas disease a neglected tropical disease in developed countries: data from Spain.. The American journal of tropical medicine and hygiene, 87 ((3)): (489-490). [PMID:22826485] |
3. Rebecca Voelker. (2012-08-02) Congenital Chagas disease reported in United States.. JAMA, 308 ((5)): (443-443). [PMID:22851094] |
4. Belinda S Hall,Emma Louise Meredith,Shane R Wilkinson. (2012-09-06) Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs.. Antimicrobial agents and chemotherapy, 56 ((11)): (5821-5830). [PMID:22948871] |
5. Otacilio C Moreira,Juan David Ramírez,Elsa Velázquez,Myllena F A Dias Melo,Carolina Lima-Ferreira,Felipe Guhl,Sergio Sosa-Estani,Jose Antonio Marin-Neto,Carlos A Morillo,Constança Britto. (2012-09-18) Towards the establishment of a consensus real-time qPCR to monitor Trypanosoma cruzi parasitemia in patients with chronic Chagas disease cardiomyopathy: a substudy from the BENEFIT trial.. Acta tropica, 125 ((1)): (23-31). [PMID:22982466] |
6. Sabrina Cencig,Nicolas Coltel,Carine Truyens,Yves Carlier. (2012-10-16) Evaluation of benznidazole treatment combined with nifurtimox, posaconazole or AmBisome® in mice infected with Trypanosoma cruzi strains.. International journal of antimicrobial agents, 40 ((6)): (527-532). [PMID:23063742] |
7. Juliana Cogo,Angelo de Oliveira Caleare,Tânia Ueda-Nakamura,Benedito Prado Dias Filho,Izabel Cristina Piloto Ferreira,Celso Vataru Nakamura. (2012-10-17) Trypanocidal activity of guaianolide obtained from Tanacetum parthenium (L.) Schultz-Bip. and its combinational effect with benznidazole.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 20 ((1)): (59-66). [PMID:23069248] |
8. Ivo Santana Caldas,Paulo Marcos da Matta Guedes,Fabiane Matos dos Santos,Lívia de Figueiredo Diniz,Tassiane Assíria Fontes Martins,Alvaro Fernando da Silva do Nascimento,Maira Araújo Azevedo,Wanderson Geraldo de Lima,Raimundo Marques Nascimento Neto,Rosália Morais Torres,André Talvani,Maria Terezinha Bahia. (2012-10-31) Myocardial scars correlate with eletrocardiographic changes in chronic Trypanosoma cruzi infection for dogs treated with Benznidazole.. Tropical medicine & international health : TM & IH, 18 ((1)): (75-84). [PMID:23107306] |
9. María-Jesús Pinazo,Laura Guerrero,Elizabeth Posada,Elena Rodríguez,Dolors Soy,Joaquim Gascon. (2012-11-02) Benznidazole-related adverse drug reactions and their relationship to serum drug concentrations in patients with chronic chagas disease.. Antimicrobial agents and chemotherapy, 57 ((1)): (390-395). [PMID:23114763] |
10. Ana P M Teston,Wuelton M Monteiro,Daniele Reis,Gleison D P Bossolani,Mônica L Gomes,Silvana M de Araújo,Maria T Bahia,Maria G V Barbosa,Max J O Toledo. (2012-11-08) In vivo susceptibility to benznidazole of Trypanosoma cruzi strains from the western Brazilian Amazon.. Tropical medicine & international health : TM & IH, 18 ((1)): (85-95). [PMID:23130989] |
11. José M Ramos,Diego Torrús,Concepción Amador,Francisco Jover,Fabiola Pérez-Chacón,Yamileth Ponce,Francisco J Arjona,Elena Caro,Concepción Martínez-Peinado,Ingrid Gallegos,José M Cuadrado,Antonio Tello,Felix Gutiérrez. (2012-11-28) Multicenter epidemiological and clinical study on imported Chagas diseases in Alicante, Spain.. Pathogens and global health, 106 ((6)): (340-345). [PMID:23182138] |
12. Juan P Rigalli,Virginia G Perdomo,Marcelo G Luquita,Silvina S M Villanueva,Agostina Arias,Dirk Theile,Johanna Weiss,Aldo D Mottino,María L Ruiz,Viviana A Catania. (2012-12-29) Regulation of biotransformation systems and ABC transporters by benznidazole in HepG2 cells: involvement of pregnane X-receptor.. PLoS neglected tropical diseases, 6 ((12)): (e1951-e1951). [PMID:23272261] |
13. Jean-Philippe Chippaux,Alejandra Nadin Salas-Clavijo,Jorge Rene Postigo,Dominique Schneider,Jose Antonio Santalla,Laurent Brutus. (2013-01-09) Evaluation of compliance to congenital Chagas disease treatment: results of a randomised trial in Bolivia.. Transactions of the Royal Society of Tropical Medicine and Hygiene, 107 ((1)): (1-7). [PMID:23296694] |
14. Darío Leonardi,Claudio J Salomon. (2013-01-11) Unexpected performance of physical mixtures over solid dispersions on the dissolution behavior of benznidazole from tablets.. Journal of pharmaceutical sciences, 102 ((3)): (1016-1023). [PMID:23303640] |
15. María-Jesús Pinazo,Gerard Espinosa,Cristina Cortes-Lletget,Elizabeth de Jesús Posada,Edelweiss Aldasoro,Inés Oliveira,Jose Muñoz,Montserrat Gállego,Joaquim Gascon. (2013-01-26) Immunosuppression and Chagas disease: a management challenge.. PLoS neglected tropical diseases, 7 ((1)): (e1965-e1965). [PMID:23349998] |
16. Ignacio Martínez,Benjamín Nogueda,Fernando Martínez-Hernández,Bertha Espinoza. (2013-02-21) Microsatellite and mini-exon analysis of Mexican human DTU I Trypanosoma cruzi strains and their susceptibility to nifurtimox and benznidazole.. Vector borne and zoonotic diseases (Larchmont, N.Y.), 13 ((3)): (181-187). [PMID:23421890] |
17. Andrew A Voak,Vithurshaa Gobalakrishnapillai,Karin Seifert,Edina Balczo,Longqin Hu,Belinda S Hall,Shane R Wilkinson. (2013-08-16) An essential type I nitroreductase from Leishmania major can be used to activate leishmanicidal prodrugs.. The Journal of biological chemistry, 288 ((40)): (28466-28476). [PMID:23946481] |
18. Sara Braga Honorato,Jorge Souza Mendonça,Nubia Boechat,Alcemira Conceição Oliveira,Josué Mendes Filho,Javier Ellena,Alejandro Pedro Ayala. (2013-10-01) Novel polymorphs of the anti-Trypanosoma cruzi drug benznidazole.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 118 (389-394). [PMID:24076454] |
19. Andrea Trochine,Guzmán Alvarez,Sandra Corre,Paula Faral-Tello,Rosario Durán,Carlos I Batthyany,Hugo Cerecetto,Mercedes González,Carlos Robello. (2014-03-19) Trypanosoma cruzi chemical proteomics using immobilized benznidazole.. Experimental parasitology, 140 (33-38). [PMID:24632192] |
20. Facundo García-Bournissen,Samanta Moroni,Maria Elena Marson,Guillermo Moscatelli,Guido Mastrantonio,Margarita Bisio,Laura Cornou,Griselda Ballering,Jaime Altcheh. (2014-09-12) Limited infant exposure to benznidazole through breast milk during maternal treatment for Chagas disease.. Archives of disease in childhood, 100 ((1)): (90-94). [PMID:25210104] |
21. Jennifer Manne-Goehler,Janine M Ramsey,Marco Ocampo Salgado,Veronika J Wirtz,Michael R Reich. (2014-10-01) Short report: Increasing access to treatment for Chagas disease: the case of Morelos, Mexico.. The American journal of tropical medicine and hygiene, 91 ((6)): (1125-1127). [PMID:25266353] |
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