Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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B139120-50mg | 50mg | In stock | $133.90 | |
B139120-100mg | 100mg | In stock | $189.90 | |
B139120-500mg | 500mg | In stock | $316.90 | |
B139120-1g | 1g | In stock | $416.90 | |
B139120-5g | 5g | In stock | $1,665.90 |
Isoquinoline alkaloid. Apoptotic anticancer agent.
Synonyms | BBR | 5,6-DIHYDRO-9,10-DIMETHOXYBENZO(G)-1,3-BENZODIOXOLO(5,6-A)QUINOLIZINIUM CHLORIDE | Berbinium,8,13,13a-tetradehydro-9.10-dimethoxy-2,3-(methylene dioxy)-, chloride | MLS002153890 | NCGC00016526-02 | SW196403-2 | Berbinium, 7,8,13,13a-tetradehydro-9,1 |
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Specifications & Purity | ≥95% |
Biochemical and Physiological Mechanisms | An alkaloid with weak antibiotic properties. Substrate for MDR efflux pumps. Antimicrobial activities of berberine is potentiated by the MDR inhibitor 5′-methoxyhydnocarpin (5′-MHC). Berberine upregulates the expression of Pgp in hepatoma cells. Treatment |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Product Application: Berberine is an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme Cox-2 (cyclooxygenase-2) which is abundantly expressed in colon cancer cells. Also inhibits c-Jun (Activator Protein 1), a transcription factor that plays a critical role in inflammation and carcinogenesis. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene;chloride |
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INCHI | InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1 |
InChi Key | VKJGBAJNNALVAV-UHFFFAOYSA-M |
Canonical SMILES | COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-] |
Isomeric SMILES | COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-] |
PubChem CID | 12456 |
Molecular Weight | 371.81 |
Beilstein | 3836585 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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F2419122 | Certificate of Analysis | Mar 22, 2024 | B139120 |
F2419123 | Certificate of Analysis | Mar 22, 2024 | B139120 |
B2309262 | Certificate of Analysis | Feb 21, 2023 | B139120 |
B2309261 | Certificate of Analysis | Feb 21, 2023 | B139120 |
B2309302 | Certificate of Analysis | Feb 21, 2023 | B139120 |
B2309260 | Certificate of Analysis | Feb 20, 2023 | B139120 |
B2309274 | Certificate of Analysis | Feb 20, 2023 | B139120 |
Solubility | Soluble in DMSO (74 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and methanol. |
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Sensitivity | Hygroscopic;Moisture sensitive. |
Pictogram(s) | GHS08 |
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Signal | Warning |
Hazard Statements | H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. |
1. Wei Ming Liu, Hui Yun Zhou, Li Jun Ren, Jia Jia Yang, Pei Yan Hao, Jia Nan Tong, Ya Wei Chen, Jun Liang Chen, Hyun Jin Park. (2023) Optimization, Characterization, Molecular Docking, and In Vitro Release of BBH/Lysine-β-cyclodextrin Inclusion Complex. ChemistrySelect, 8 (45): (e202303620). [PMID:11076860] [10.1002/slct.202303620] |
2. Gang Liu, Fengli Gao, Xiupei Yang, Jingyi Zhang, Suling Yang, Yuanyuan Li, Lin Liu. (2023) Aggregation-induced emission for the detection of peptide ligases with improving ligation efficiency. ANALYTICA CHIMICA ACTA, 1284 (7): (341994). [PMID:37996157] [10.1016/j.aca.2023.341994] |
3. Junpeng Sun, Xiaobang Liu, Jiaqun Du, Jinyu An, Yingqiao Li, Yu Hu, Shuai Cheng, Ying Xiong, Yanan Yu, He Tian, Xifan Mei, Chao Wu. (2023) Manganese-doped albumin-gelatin composite nanogel loaded with berberine applied to the treatment of gouty arthritis in rats via a SPARC-dependent mechanism. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 253 (5): (126999). [PMID:37730000] [10.1016/j.ijbiomac.2023.126999] |
4. Kexin Zhang, Jiaxin Zhu, Ruyi Wang, Wanfang Zhu, Zhongtao Zhang, Liangping Gong, Feng Feng, Wenyuan Liu, Lingfei Han, Wei Qu. (2023) Mitochondria-anchoring self-assembled nanoparticles for multi-path energy depletion: A “nano bomb” in chemo-co-starvation therapy. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 642 (123180). [PMID:37364784] [10.1016/j.ijpharm.2023.123180] |
5. Chengde Liu, Wanting Du, Luyao Jiang, Yizheng Li, Cheng Liu, Xigao Jian. (2023) Enhanced antibacterial and adhesive properties of chitosan/gelatin hydrogel containing berberine hydrochloride and prepolymerized gallic acid exhibiting aggregation-induced emission. POLYMER ENGINEERING AND SCIENCE, 63 (8): (2596-2612). [PMID:] [10.1002/pen.26398] |
6. Yong Zhu, Hailun Li, Huiran Jin, Jingrui Ma, Zhandong Ye, Bingmin Wu, Ying Zhang, Qingping Xiong, Shijie Ding, Jing Chen, Song Huang. (2023) An efficient and green separation method of total alkaloids by resorcinol-formaldehyde aerogel during extraction of Coptis chinensis. INDUSTRIAL CROPS AND PRODUCTS, 195 (116438). [PMID:] [10.1016/j.indcrop.2023.116438] |
7. Huang Xuemei, Liu Xiaojing, Lin Xiaoyu, Yuan Zhihua, Zhang Yaozhi, Wang Zhijia, Pi Wenmin, Zhao Haoqiang, Lei Haimin, Wang Penglong. (2022) Thermodynamics driving phytochemical self-assembly morphological change and efficacy enhancement originated from single and co-decoction of traditional chinese medicine. JOURNAL OF NANOBIOTECHNOLOGY, 20 (1): (1-15). [PMID:36510210] [10.1186/s12951-022-01734-w] |
8. Jingliang Wu, Cuiping Qi, Hao Wang, Qing Wang, Jingui Sun, Jinping Dong, Guohua Yu, Zhiqin Gao, Bo Zhang, Guixiang Tian. (2022) Curcumin and berberine co-loaded liposomes for anti-hepatocellular carcinoma therapy by blocking the cross-talk between hepatic stellate cells and tumor cells. Frontiers in Pharmacology, 13 (961788). [PMID:36188590] [10.3389/fphar.2022.961788] |
9. Tingting Zhao, Qin Zhang, Feng Cang, Shilong Wu, Yu Jiang, Qiyao Zhao, Yifan Zhou, Xiaomeng Qu, Xuesong Zhang, Yushen Jin, Yanyan Li, Yujie Fu. (2022) Yolk-shell shaped Au-Bi2S3 heterostructure nanoparticles for controlled drug release and combined tumor therapy. NANOTECHNOLOGY, 33 (45): (455103). [PMID:35914421] [10.1088/1361-6528/ac85c2] |
10. Xingxing Feng, Qi Xie, Hongbo Xu, Tiantian Zhang, Xiaonan Li, Yinmei Tian, Hongbing Lan, Li Kong, Zhiping Zhang. (2022) Yeast Microcapsule Mediated Natural Products Delivery for Treating Ulcerative Colitis through Anti-Inflammatory and Regulation of Macrophage Polarization. ACS Applied Materials & Interfaces, 14 (27): (31085–31098). [PMID:35770618] [10.1021/acsami.2c05642] |
11. Li Mo, She Jiang, Ma Louyan, Ma Li, Ma Xiaorui, Zhai Jiajia. (2022) Berberine protects against palmitate induced beta cell injury via promoting mitophagy. Genes & Genomics, 44 (7): (867-878). [PMID:35633490] [10.1007/s13258-022-01250-z] |
12. Longfa Kou, Huirong Huang, Yingying Tang, Meng Sun, Yingtao Li, Jianing Wu, Shimin Zheng, Xinyu Zhao, Daosen Chen, Zucheng Luo, Xiaolei Zhang, Qing Yao, Ruijie Chen. (2022) Opsonized nanoparticles target and regulate macrophage polarization for osteoarthritis therapy: A trapping strategy. JOURNAL OF CONTROLLED RELEASE, 347 (237). [PMID:35489544] [10.1016/j.jconrel.2022.04.037] |
13. Haofeng Hu, Fulin Luo, Qian Zhang, Ming Xu, Xin Chen, Zhihao Liu, Haodong Xu, Lei Wang, Fei Ye, Kui Zhang, Bin Chen, Song Zheng, Jia Jin. (2022) Berberine coated biocomposite hemostatic film based alginate as absorbable biomaterial for wound healing. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 209 (1731). [PMID:35487376] [10.1016/j.ijbiomac.2022.04.132] |
14. Yingxin Chen, Xiaotong Huang, Lu Li, Junxian Wu, Yongqi Guo, Yachao Yao, Lihua Zhou. (2022) Paper mill sludge-based carbon quantum dots as a specifically ratiometric fluorescent probe for the sensitive and selective detection of coptisine. LUMINESCENCE, 37 (7): (1078-1086). [PMID:35441456] [10.1002/bio.4260] |
15. Jia-Man Liang, Fang Zhang, Yu-Lin Zhu, Xiao-Yan Deng, Xian-Ping Chen, Qiu-Ju Zhou, Ke-Jun Tan. (2022) One-pot hydrothermal synthesis of Si-doped carbon quantum dots with up-conversion fluorescence as fluorescent probes for dual-readout detection of berberine hydrochloride. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 275 (121139). [PMID:35313173] [10.1016/j.saa.2022.121139] |
16. Qin Wang, Kai-Ni Wei, Shu-Zhen Huang, Qing Tang, Zhu Tao, Ying Huang. (2021) “Turn-Off” Supramolecular Fluorescence Array Sensor for Heavy Metal Ion Identification. ACS Omega, 6 (46): (31229–31235). [PMID:34841166] [10.1021/acsomega.1c04956] |
17. Miaomiao Qi, Xiang Liu, Ying Zhou, Haoyu Wang, Ying Zhao, Jing Ren, Jin Xiang. (2021) Berberine Inhibits MDA-MB-231 Cells as an Agonist of G Protein-Coupled Estrogen Receptor 1. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22 (21): (11466). [PMID:34768896] [10.3390/ijms222111466] |
18. Liu Mingyang, Du Xuejun, Xu Ke, Yan Binwei, Fan Zaibi, Gao Zideng, Ren Xueqin. (2021) A cationic quantum dot-based ratiometric fluorescent probe to visually detect berberine hydrochloride in human blood serums. Journal of Analytical Science and Technology, 12 (1): (1-9). [PMID:] [10.1186/s40543-021-00261-x] |
19. Chao Fan, Hao Tang, Licheng Wang, Yijing Li, Xusheng Wang, Shuai Wang, Xiaojing Liang. (2020) The preparation of a core–shell stationary phase by the in situ polymerization of a hydrophilic polymer on the surface of silica and its chromatographic performance. NEW JOURNAL OF CHEMISTRY, 44 (27): (11704-11709). [PMID:] [10.1039/D0NJ01197E] |
20. Hanzhi Zhang, Chunli Lou, Jing Li, Jingwu Kang. (2020) A gold foil covered fused silica capillary tip as a sheathless interface for coupling capillary electrophoresis-mass spectrometry. JOURNAL OF CHROMATOGRAPHY A, 1624 (461215). [PMID:32540065] [10.1016/j.chroma.2020.461215] |
21. Lin Xiao, Abishek Jung Poudel, Lixia Huang, Yang Wang, Ahmed M.E. Abdalla, Guang Yang. (2020) Nanocellulose hyperfine network achieves sustained release of berberine hydrochloride solubilized with β-cyclodextrin for potential anti-infection oral administration. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 153 (633). [PMID:32147343] [10.1016/j.ijbiomac.2020.03.030] |
22. Wen Caiyan, Huang Cuiqin, Yang Mei, Fan Chongzhu, Li Qin, Zhao Jiayi, Gan Danhui, Li An, Zhu Lihong, Lu Daxiang. (2020) The Secretion from Bone Marrow Mesenchymal Stem Cells Pretreated with Berberine Rescues Neurons with Oxidative Damage Through Activation of the Keap1-Nrf2-HO-1 Signaling Pathway. NEUROTOXICITY RESEARCH, 38 (1): (59-73). [PMID:32108297] [10.1007/s12640-020-00178-0] |
23. Meng Wang, Jinglan Zhang, Huayan Zhao, Dingming Wan, Zhongxing Jiang. (2020) Berberine combined with cyclosporine A alleviates acute graft-versus-host disease in murine models. INTERNATIONAL IMMUNOPHARMACOLOGY, 81 (106205). [PMID:32050154] [10.1016/j.intimp.2020.106205] |
24. Zhou Wen-cheng, Tan Peng-fei, Chen Xing-han, Cen Ying, You Chao, Tan Lin, Li Hao, Tian Meng. (2020) Berberine-Incorporated Shape Memory Fiber Applied as a Novel Surgical Suture. Frontiers in Pharmacology, 10 [PMID:31998123] [10.3389/fphar.2019.01506] |
25. Jian Liu, Zhenjing Zhu, Yueyao Liu, Linlin Wei, Bai Li, Fengxia Mao, Ju Zhang, Yingchao Wang, Yufeng Liu. (2020) MDM2 inhibition-mediated autophagy contributes to the pro-apoptotic effect of berberine in p53-null leukemic cells. LIFE SCIENCES, 242 (117228). [PMID:31881227] [10.1016/j.lfs.2019.117228] |
26. Xuemei Huang, Penglong Wang, Tong Li, Xuehao Tian, Wenbo Guo, Bing Xu, Guangrui Huang, Desheng Cai, Fei Zhou, Hao Zhang, Haimin Lei. (2020) Self-Assemblies Based on Traditional Medicine Berberine and Cinnamic Acid for Adhesion-Induced Inhibition Multidrug-Resistant Staphylococcus aureus. ACS Applied Materials & Interfaces, 12 (1): (227–237). [PMID:31829617] [10.1021/acsami.9b17722] |
27. Hui Wang, Wenbao Wang, Bowen Gong, Zedan Wang, Yukun Feng, Weige Zhang, Shaojie Wang, Ying Peng, Jiang Zheng. (2019) Glutathione Conjugation and Protein Adduction Derived from Oxidative Debromination of Benzbromarone in Mice. DRUG METABOLISM AND DISPOSITION, 47 (11): (1281-1290). [PMID:31484654] [10.1124/dmd.119.087460] |
28. Li Li, Qiuhong Li, Lei Wei, Zhongfu Wang, Wei Ma, Fangying Liu, Yanhua Shen, Shanfang Zhang, Xiulian Zhang, Huiping Li, Yechang Qian. (2019) Dexamethasone combined with berberine is an effective therapy for bleomycin‑induced pulmonary fibrosis in rats. Experimental and Therapeutic Medicine, 18 (4): (2385-2392). [PMID:31555349] [10.3892/etm.2019.7861] |
29. Xiong Jie, Yang Lu, Gao Li Xia, Zhu Pan Pan, Chen Qian, Tan Ke Jun. (2019) A highly fluorescent lanthanide metal-organic framework as dual-mode visual sensor for berberine hydrochloride and tetracycline. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 411 (23): (5963-5973). [PMID:31300859] [10.1007/s00216-019-02004-9] |
30. Yizhen Zhang, Lifen Liu, Bart Van der Bruggen, Michael K.H. Leung, Fenglin Yang. (2019) A free-standing 3D nano-composite photo-electrode—Ag/ZnO nanorods arrays on Ni foam effectively degrade berberine. CHEMICAL ENGINEERING JOURNAL, 373 (179). [PMID:] [10.1016/j.cej.2019.05.026] |
31. Jingfu Jia, Kerong Zhang, Xue Zhou, Jinfang Ma, Xiaojing Liu, Anya Xiang, Fahuan Ge. (2019) Berberine-loaded solid proliposomes prepared using solution enhanced dispersion by supercritical CO2: Sustained release and bioavailability enhancement. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 51 (356). [PMID:] [10.1016/j.jddst.2019.03.021] |
32. Jingfu Jia, Kerong Zhang, Xue Zhou, Dan Zhou, Fahuan Ge. (2018) Precise Dissolution Control and Bioavailability Evaluation for Insoluble Drug Berberine via a Polymeric Particle Prepared Using Supercritical CO2. Polymers, 10 (11): (1198). [PMID:30961123] [10.3390/polym10111198] |
33. Han Xie, Shao Kaiyuan, Hu Wenxiang. (2018) Synthesis of 9-Substituted Berberine Derivatives with Microwave Irradiation. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 34 (4): (571-577). [PMID:] [10.1007/s40242-018-7425-6] |
34. Shiwei Wang, Yi Hou, Shurong Zhang, Jing Li, Qian Chen, Mingan Yu, Wei Li. (2018) Sustained antibacterial activity of berberine hydrochloride loaded supramolecular organoclay networks with hydrogen-bonding junctions. Journal of Materials Chemistry B, 6 (30): (4972-4984). [PMID:32255069] [10.1039/C8TB01018H] |
35. Rong Liu, Yonggang Zhang. (2018) Mechanism of UV-driven Photoelectrocatalytic Degradation of Berberine Chloride Form Using the ESR Spin-trapping Method. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 94 (4): (650-658). [PMID:29437228] [10.1111/php.12907] |
36. Juntao Yin, Yantao Hou, Yuyun Yin, Xiaoyong Song. (2017) Selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect. International Journal of Nanomedicine, [PMID:29263662] [10.2147/IJN.S144615] |
37. Hui Wang, Ying Peng, Tingjian Zhang, Qunsheng Lan, Huimin Zhao, Wenbao Wang, Yufei Zhao, Xu Wang, Jianxin Pang, Shaojie Wang, Jiang Zheng. (2017) Metabolic Epoxidation Is a Critical Step for the Development of Benzbromarone-Induced Hepatotoxicity. DRUG METABOLISM AND DISPOSITION, 45 (12): (1354-1363). [PMID:29021351] [10.1124/dmd.117.077818] |
38. Lingli He, Chuan Li, Xuyuan Liu, Qingqing Yang, Haizhi Zhang, Weiren Xu, Luyong Zhang, Changxiao Liu. (2017) Comparative study on the interaction between 3 CYP2C9 allelic isoforms and benzbromarone by using LC–MS/MS method. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1070 (97). [PMID:29100760] [10.1016/j.jchromb.2017.10.051] |
39. Ting Tan, Mingliang Zhang, Yiqun Wan, Hongdeng Qiu. (2016) Utilization of deep eutectic solvents as novel mobile phase additives for improving the separation of bioactive quaternary alkaloids. TALANTA, 149 (85). [PMID:26717817] [10.1016/j.talanta.2015.11.041] |
40. Guiju Xu, Shengju Liu, Jiaxi Peng, Wenping Lv, Ren’an Wu. (2015) Facile Synthesis of Gold@Graphitized Mesoporous Silica Nanocomposite and Its Surface-Assisted Laser Desorption/Ionization for Time-of-Flight Mass Spectroscopy. ACS Applied Materials & Interfaces, 7 (3): (2032–2038). [PMID:25552293] [10.1021/am507894y] |
41. Siyuan Sun, Kai Wang, Hongmei Lei, Liping Li, Meijuan Tu, Su Zeng, Hui Zhou, Huidi Jiang. (2014) Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 49 (1). [PMID:24246570] [10.1016/j.pnpbp.2013.11.005] |
42. Sui Xiao, Li-Fang Zhang, Xu Zhang, Su-Mei Li, Fei-Qun Xue. (2013) Tracing antibacterial compounds from Acalypha australis Linn. by spectrum-effect relationships and semi-preparative HPLC. JOURNAL OF SEPARATION SCIENCE, 36 (9-10): (1667-1676). [PMID:23495243] [10.1002/jssc.201201202] |
43. Wenpeng Zhang, Zilin Chen. (2013) Preparation of micropipette tip-based molecularly imprinted monolith for selective micro-solid phase extraction of berberine in plasma and urine samples. TALANTA, 103 (103). [PMID:23200364] [10.1016/j.talanta.2012.10.014] |
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8. Yong Zhu, Hailun Li, Huiran Jin, Jingrui Ma, Zhandong Ye, Bingmin Wu, Ying Zhang, Qingping Xiong, Shijie Ding, Jing Chen, Song Huang. (2023) An efficient and green separation method of total alkaloids by resorcinol-formaldehyde aerogel during extraction of Coptis chinensis. INDUSTRIAL CROPS AND PRODUCTS, 195 (116438). [PMID:] [10.1016/j.indcrop.2023.116438] |
9. Huang Xuemei, Liu Xiaojing, Lin Xiaoyu, Yuan Zhihua, Zhang Yaozhi, Wang Zhijia, Pi Wenmin, Zhao Haoqiang, Lei Haimin, Wang Penglong. (2022) Thermodynamics driving phytochemical self-assembly morphological change and efficacy enhancement originated from single and co-decoction of traditional chinese medicine. JOURNAL OF NANOBIOTECHNOLOGY, 20 (1): (1-15). [PMID:36510210] [10.1186/s12951-022-01734-w] |
10. Jingliang Wu, Cuiping Qi, Hao Wang, Qing Wang, Jingui Sun, Jinping Dong, Guohua Yu, Zhiqin Gao, Bo Zhang, Guixiang Tian. (2022) Curcumin and berberine co-loaded liposomes for anti-hepatocellular carcinoma therapy by blocking the cross-talk between hepatic stellate cells and tumor cells. Frontiers in Pharmacology, 13 (961788). [PMID:36188590] [10.3389/fphar.2022.961788] |
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12. Xingxing Feng, Qi Xie, Hongbo Xu, Tiantian Zhang, Xiaonan Li, Yinmei Tian, Hongbing Lan, Li Kong, Zhiping Zhang. (2022) Yeast Microcapsule Mediated Natural Products Delivery for Treating Ulcerative Colitis through Anti-Inflammatory and Regulation of Macrophage Polarization. ACS Applied Materials & Interfaces, 14 (27): (31085–31098). [PMID:35770618] [10.1021/acsami.2c05642] |
13. Li Mo, She Jiang, Ma Louyan, Ma Li, Ma Xiaorui, Zhai Jiajia. (2022) Berberine protects against palmitate induced beta cell injury via promoting mitophagy. Genes & Genomics, 44 (7): (867-878). [PMID:35633490] [10.1007/s13258-022-01250-z] |
14. Longfa Kou, Huirong Huang, Yingying Tang, Meng Sun, Yingtao Li, Jianing Wu, Shimin Zheng, Xinyu Zhao, Daosen Chen, Zucheng Luo, Xiaolei Zhang, Qing Yao, Ruijie Chen. (2022) Opsonized nanoparticles target and regulate macrophage polarization for osteoarthritis therapy: A trapping strategy. JOURNAL OF CONTROLLED RELEASE, 347 (237). [PMID:35489544] [10.1016/j.jconrel.2022.04.037] |
15. Haofeng Hu, Fulin Luo, Qian Zhang, Ming Xu, Xin Chen, Zhihao Liu, Haodong Xu, Lei Wang, Fei Ye, Kui Zhang, Bin Chen, Song Zheng, Jia Jin. (2022) Berberine coated biocomposite hemostatic film based alginate as absorbable biomaterial for wound healing. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 209 (1731). [PMID:35487376] [10.1016/j.ijbiomac.2022.04.132] |
16. Yingxin Chen, Xiaotong Huang, Lu Li, Junxian Wu, Yongqi Guo, Yachao Yao, Lihua Zhou. (2022) Paper mill sludge-based carbon quantum dots as a specifically ratiometric fluorescent probe for the sensitive and selective detection of coptisine. LUMINESCENCE, 37 (7): (1078-1086). [PMID:35441456] [10.1002/bio.4260] |
17. Jia-Man Liang, Fang Zhang, Yu-Lin Zhu, Xiao-Yan Deng, Xian-Ping Chen, Qiu-Ju Zhou, Ke-Jun Tan. (2022) One-pot hydrothermal synthesis of Si-doped carbon quantum dots with up-conversion fluorescence as fluorescent probes for dual-readout detection of berberine hydrochloride. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 275 (121139). [PMID:35313173] [10.1016/j.saa.2022.121139] |
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19. Miaomiao Qi, Xiang Liu, Ying Zhou, Haoyu Wang, Ying Zhao, Jing Ren, Jin Xiang. (2021) Berberine Inhibits MDA-MB-231 Cells as an Agonist of G Protein-Coupled Estrogen Receptor 1. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22 (21): (11466). [PMID:34768896] [10.3390/ijms222111466] |
20. Liu Mingyang, Du Xuejun, Xu Ke, Yan Binwei, Fan Zaibi, Gao Zideng, Ren Xueqin. (2021) A cationic quantum dot-based ratiometric fluorescent probe to visually detect berberine hydrochloride in human blood serums. Journal of Analytical Science and Technology, 12 (1): (1-9). [PMID:] [10.1186/s40543-021-00261-x] |
21. Chao Fan, Hao Tang, Licheng Wang, Yijing Li, Xusheng Wang, Shuai Wang, Xiaojing Liang. (2020) The preparation of a core–shell stationary phase by the in situ polymerization of a hydrophilic polymer on the surface of silica and its chromatographic performance. NEW JOURNAL OF CHEMISTRY, 44 (27): (11704-11709). [PMID:] [10.1039/D0NJ01197E] |
22. Hanzhi Zhang, Chunli Lou, Jing Li, Jingwu Kang. (2020) A gold foil covered fused silica capillary tip as a sheathless interface for coupling capillary electrophoresis-mass spectrometry. JOURNAL OF CHROMATOGRAPHY A, 1624 (461215). [PMID:32540065] [10.1016/j.chroma.2020.461215] |
23. Lin Xiao, Abishek Jung Poudel, Lixia Huang, Yang Wang, Ahmed M.E. Abdalla, Guang Yang. (2020) Nanocellulose hyperfine network achieves sustained release of berberine hydrochloride solubilized with β-cyclodextrin for potential anti-infection oral administration. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 153 (633). [PMID:32147343] [10.1016/j.ijbiomac.2020.03.030] |
24. Wen Caiyan, Huang Cuiqin, Yang Mei, Fan Chongzhu, Li Qin, Zhao Jiayi, Gan Danhui, Li An, Zhu Lihong, Lu Daxiang. (2020) The Secretion from Bone Marrow Mesenchymal Stem Cells Pretreated with Berberine Rescues Neurons with Oxidative Damage Through Activation of the Keap1-Nrf2-HO-1 Signaling Pathway. NEUROTOXICITY RESEARCH, 38 (1): (59-73). [PMID:32108297] [10.1007/s12640-020-00178-0] |
25. Meng Wang, Jinglan Zhang, Huayan Zhao, Dingming Wan, Zhongxing Jiang. (2020) Berberine combined with cyclosporine A alleviates acute graft-versus-host disease in murine models. INTERNATIONAL IMMUNOPHARMACOLOGY, 81 (106205). [PMID:32050154] [10.1016/j.intimp.2020.106205] |
26. Zhou Wen-cheng, Tan Peng-fei, Chen Xing-han, Cen Ying, You Chao, Tan Lin, Li Hao, Tian Meng. (2020) Berberine-Incorporated Shape Memory Fiber Applied as a Novel Surgical Suture. Frontiers in Pharmacology, 10 [PMID:31998123] [10.3389/fphar.2019.01506] |
27. Jian Liu, Zhenjing Zhu, Yueyao Liu, Linlin Wei, Bai Li, Fengxia Mao, Ju Zhang, Yingchao Wang, Yufeng Liu. (2020) MDM2 inhibition-mediated autophagy contributes to the pro-apoptotic effect of berberine in p53-null leukemic cells. LIFE SCIENCES, 242 (117228). [PMID:31881227] [10.1016/j.lfs.2019.117228] |
28. Xuemei Huang, Penglong Wang, Tong Li, Xuehao Tian, Wenbo Guo, Bing Xu, Guangrui Huang, Desheng Cai, Fei Zhou, Hao Zhang, Haimin Lei. (2020) Self-Assemblies Based on Traditional Medicine Berberine and Cinnamic Acid for Adhesion-Induced Inhibition Multidrug-Resistant Staphylococcus aureus. ACS Applied Materials & Interfaces, 12 (1): (227–237). [PMID:31829617] [10.1021/acsami.9b17722] |
29. Hui Wang, Wenbao Wang, Bowen Gong, Zedan Wang, Yukun Feng, Weige Zhang, Shaojie Wang, Ying Peng, Jiang Zheng. (2019) Glutathione Conjugation and Protein Adduction Derived from Oxidative Debromination of Benzbromarone in Mice. DRUG METABOLISM AND DISPOSITION, 47 (11): (1281-1290). [PMID:31484654] [10.1124/dmd.119.087460] |
30. Li Li, Qiuhong Li, Lei Wei, Zhongfu Wang, Wei Ma, Fangying Liu, Yanhua Shen, Shanfang Zhang, Xiulian Zhang, Huiping Li, Yechang Qian. (2019) Dexamethasone combined with berberine is an effective therapy for bleomycin‑induced pulmonary fibrosis in rats. Experimental and Therapeutic Medicine, 18 (4): (2385-2392). [PMID:31555349] [10.3892/etm.2019.7861] |
31. Xiong Jie, Yang Lu, Gao Li Xia, Zhu Pan Pan, Chen Qian, Tan Ke Jun. (2019) A highly fluorescent lanthanide metal-organic framework as dual-mode visual sensor for berberine hydrochloride and tetracycline. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 411 (23): (5963-5973). [PMID:31300859] [10.1007/s00216-019-02004-9] |
32. Yizhen Zhang, Lifen Liu, Bart Van der Bruggen, Michael K.H. Leung, Fenglin Yang. (2019) A free-standing 3D nano-composite photo-electrode—Ag/ZnO nanorods arrays on Ni foam effectively degrade berberine. CHEMICAL ENGINEERING JOURNAL, 373 (179). [PMID:] [10.1016/j.cej.2019.05.026] |
33. Jingfu Jia, Kerong Zhang, Xue Zhou, Jinfang Ma, Xiaojing Liu, Anya Xiang, Fahuan Ge. (2019) Berberine-loaded solid proliposomes prepared using solution enhanced dispersion by supercritical CO2: Sustained release and bioavailability enhancement. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 51 (356). [PMID:] [10.1016/j.jddst.2019.03.021] |
34. Jingfu Jia, Kerong Zhang, Xue Zhou, Dan Zhou, Fahuan Ge. (2018) Precise Dissolution Control and Bioavailability Evaluation for Insoluble Drug Berberine via a Polymeric Particle Prepared Using Supercritical CO2. Polymers, 10 (11): (1198). [PMID:30961123] [10.3390/polym10111198] |
35. Han Xie, Shao Kaiyuan, Hu Wenxiang. (2018) Synthesis of 9-Substituted Berberine Derivatives with Microwave Irradiation. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 34 (4): (571-577). [PMID:] [10.1007/s40242-018-7425-6] |
36. Shiwei Wang, Yi Hou, Shurong Zhang, Jing Li, Qian Chen, Mingan Yu, Wei Li. (2018) Sustained antibacterial activity of berberine hydrochloride loaded supramolecular organoclay networks with hydrogen-bonding junctions. Journal of Materials Chemistry B, 6 (30): (4972-4984). [PMID:32255069] [10.1039/C8TB01018H] |
37. Rong Liu, Yonggang Zhang. (2018) Mechanism of UV-driven Photoelectrocatalytic Degradation of Berberine Chloride Form Using the ESR Spin-trapping Method. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 94 (4): (650-658). [PMID:29437228] [10.1111/php.12907] |
38. Juntao Yin, Yantao Hou, Yuyun Yin, Xiaoyong Song. (2017) Selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect. International Journal of Nanomedicine, [PMID:29263662] [10.2147/IJN.S144615] |
39. Hui Wang, Ying Peng, Tingjian Zhang, Qunsheng Lan, Huimin Zhao, Wenbao Wang, Yufei Zhao, Xu Wang, Jianxin Pang, Shaojie Wang, Jiang Zheng. (2017) Metabolic Epoxidation Is a Critical Step for the Development of Benzbromarone-Induced Hepatotoxicity. DRUG METABOLISM AND DISPOSITION, 45 (12): (1354-1363). [PMID:29021351] [10.1124/dmd.117.077818] |
40. Lingli He, Chuan Li, Xuyuan Liu, Qingqing Yang, Haizhi Zhang, Weiren Xu, Luyong Zhang, Changxiao Liu. (2017) Comparative study on the interaction between 3 CYP2C9 allelic isoforms and benzbromarone by using LC–MS/MS method. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1070 (97). [PMID:29100760] [10.1016/j.jchromb.2017.10.051] |
41. Ting Tan, Mingliang Zhang, Yiqun Wan, Hongdeng Qiu. (2016) Utilization of deep eutectic solvents as novel mobile phase additives for improving the separation of bioactive quaternary alkaloids. TALANTA, 149 (85). [PMID:26717817] [10.1016/j.talanta.2015.11.041] |
42. Guiju Xu, Shengju Liu, Jiaxi Peng, Wenping Lv, Ren’an Wu. (2015) Facile Synthesis of Gold@Graphitized Mesoporous Silica Nanocomposite and Its Surface-Assisted Laser Desorption/Ionization for Time-of-Flight Mass Spectroscopy. ACS Applied Materials & Interfaces, 7 (3): (2032–2038). [PMID:25552293] [10.1021/am507894y] |
43. Siyuan Sun, Kai Wang, Hongmei Lei, Liping Li, Meijuan Tu, Su Zeng, Hui Zhou, Huidi Jiang. (2014) Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 49 (1). [PMID:24246570] [10.1016/j.pnpbp.2013.11.005] |
44. Sui Xiao, Li-Fang Zhang, Xu Zhang, Su-Mei Li, Fei-Qun Xue. (2013) Tracing antibacterial compounds from Acalypha australis Linn. by spectrum-effect relationships and semi-preparative HPLC. JOURNAL OF SEPARATION SCIENCE, 36 (9-10): (1667-1676). [PMID:23495243] [10.1002/jssc.201201202] |
45. Wenpeng Zhang, Zilin Chen. (2013) Preparation of micropipette tip-based molecularly imprinted monolith for selective micro-solid phase extraction of berberine in plasma and urine samples. TALANTA, 103 (103). [PMID:23200364] [10.1016/j.talanta.2012.10.014] |