Berberine chloride form - ≥95%, high purity , CAS No.633-65-8

17 Citations
  • ≥95%
Item Number
B139120
Grouped product items
SKUSizeAvailabilityPrice Qty
B139120-50mg
50mg
In stock
$133.90
B139120-100mg
100mg
In stock
$189.90
B139120-500mg
500mg
In stock
$316.90
B139120-1g
1g
In stock
$416.90
B139120-5g
5g
In stock
$1,665.90

Isoquinoline alkaloid. Apoptotic anticancer agent.

Basic Description

SynonymsBBR | 5,6-DIHYDRO-9,10-DIMETHOXYBENZO(G)-1,3-BENZODIOXOLO(5,6-A)QUINOLIZINIUM CHLORIDE | Berbinium,8,13,13a-tetradehydro-9.10-dimethoxy-2,3-(methylene dioxy)-, chloride | MLS002153890 | NCGC00016526-02 | SW196403-2 | Berbinium, 7,8,13,13a-tetradehydro-9,1
Specifications & Purity≥95%
Biochemical and Physiological MechanismsAn alkaloid with weak antibiotic properties. Substrate for MDR efflux pumps. Antimicrobial activities of berberine is potentiated by the MDR inhibitor 5′-methoxyhydnocarpin (5′-MHC). Berberine upregulates the expression of Pgp in hepatoma cells. Treatment
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Product Application:

Berberine is an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme Cox-2 (cyclooxygenase-2) which is abundantly expressed in colon cancer cells. Also inhibits c-Jun (Activator Protein 1), a transcription factor that plays a critical role in inflammation and carcinogenesis.
Fluorescent stain for heparin in mast cells.

Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties

Associated Targets(Human)

CYP1B1 Tchem Cytochrome P450 1B1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ACHE Tclin Acetylcholinesterase (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PDE5A Tclin Phosphodiesterase 5A (5113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HMGCR Tclin HMG-CoA reductase (2475 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
INSR Tclin Insulin receptor (5558 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACE Tclin Angiotensin-converting enzyme (1423 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD4 Tchem Dopamine D4 receptor (7907 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1D Tclin Alpha-1d adrenergic receptor (4171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CALCR Tclin Calcitonin receptor (2215 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1B Tclin Alpha-1b adrenergic receptor (2912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTH1R Tclin Parathyroid hormone receptor (47172 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCC8 Tclin Sulfonylurea receptor 1 (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR4 Tclin Serotonin 4 (5-HT4) receptor (2068 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR2 Tclin Estrogen receptor beta (9272 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYSLTR1 Tclin Cysteinyl leukotriene receptor 1 (2118 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

pol Human immunodeficiency virus type 1 reverse transcriptase (18245 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ampC Beta-lactamase AmpC (62480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ltc4s Leukotriene C4 synthase (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Sigmar1 Sigma opioid receptor (160 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cckar Cholecystokinin A receptor (90 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ppard Peroxisome proliferator-activated receptor delta (358 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PREP Prolyl endopeptidase (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abcb1b P-glycoprotein 1 (174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ftsZ Cell division protein ftsZ (97 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptococcus pneumoniae (31063 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Proteus vulgaris (5823 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Micrococcus luteus (7463 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus epidermidis (22802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Salmonella enteritidis (727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Salmonella typhi (4293 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Shigella dysenteriae (933 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptococcus pyogenes (16140 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterococcus faecium (13803 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus pumilus (984 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aspergillus flavus (8875 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus subtilis (32866 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium tuberculosis (203094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Phytophthora infestans (820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cyberlindnera jadinii (900 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Saccharomyces cerevisiae (19171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterococcus faecalis (29875 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium intracellulare (1532 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycolicibacterium smegmatis (8003 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pichia kudriavzevii (7448 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aspergillus fumigatus (16427 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Entamoeba histolytica (2676 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ustilago maydis (75 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida (1648 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida tropicalis (8381 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Scedosporium boydii (94 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium yoelii (6656 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human betaherpesvirus 5 (5122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene;chloride
INCHI InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1
InChi Key VKJGBAJNNALVAV-UHFFFAOYSA-M
Canonical SMILES COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]
Isomeric SMILES COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]
PubChem CID 12456
Molecular Weight 371.81
Beilstein 3836585

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot NumberCertificate TypeDateItem
F2419122Certificate of AnalysisMar 22, 2024 B139120
F2419123Certificate of AnalysisMar 22, 2024 B139120
B2309262Certificate of AnalysisFeb 21, 2023 B139120
B2309261Certificate of AnalysisFeb 21, 2023 B139120
B2309302Certificate of AnalysisFeb 21, 2023 B139120
B2309260Certificate of AnalysisFeb 20, 2023 B139120
B2309274Certificate of AnalysisFeb 20, 2023 B139120

Chemical and Physical Properties

SolubilitySoluble in DMSO (74 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and methanol.
SensitivityHygroscopic;Moisture sensitive.

Safety and Hazards(GHS)

Pictogram(s) GHS08
Signal Warning
Hazard Statements

H361:Suspected of damaging fertility or the unborn child

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P405:Store locked up.

P501:Dispose of contents/container to ...

P203:Obtain, read and follow all safety instructions before use.

P318:if exposed or concerned, get medical advice.

Related Documents

Citations of This Product

1. Wei Ming Liu, Hui Yun Zhou, Li Jun Ren, Jia Jia Yang, Pei Yan Hao, Jia Nan Tong, Ya Wei Chen, Jun Liang Chen, Hyun Jin Park.  (2023)  Optimization, Characterization, Molecular Docking, and In Vitro Release of BBH/Lysine-β-cyclodextrin Inclusion Complex.  ChemistrySelect,  (45): (e202303620).  [PMID:11076860]
2. Gang Liu, Fengli Gao, Xiupei Yang, Jingyi Zhang, Suling Yang, Yuanyuan Li, Lin Liu.  (2023)  Aggregation-induced emission for the detection of peptide ligases with improving ligation efficiency.  ANALYTICA CHIMICA ACTA,  1284  (7): (341994).  [PMID:37996157]
3. Junpeng Sun, Xiaobang Liu, Jiaqun Du, Jinyu An, Yingqiao Li, Yu Hu, Shuai Cheng, Ying Xiong, Yanan Yu, He Tian, Xifan Mei, Chao Wu.  (2023)  Manganese-doped albumin-gelatin composite nanogel loaded with berberine applied to the treatment of gouty arthritis in rats via a SPARC-dependent mechanism.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  253  (5): (126999).  [PMID:37730000]
4. Kexin Zhang, Jiaxin Zhu, Ruyi Wang, Wanfang Zhu, Zhongtao Zhang, Liangping Gong, Feng Feng, Wenyuan Liu, Lingfei Han, Wei Qu.  (2023)  Mitochondria-anchoring self-assembled nanoparticles for multi-path energy depletion: A “nano bomb” in chemo-co-starvation therapy.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  642  (123180).  [PMID:37364784]
5. Chengde Liu, Wanting Du, Luyao Jiang, Yizheng Li, Cheng Liu, Xigao Jian.  (2023)  Enhanced antibacterial and adhesive properties of chitosan/gelatin hydrogel containing berberine hydrochloride and prepolymerized gallic acid exhibiting aggregation-induced emission.  POLYMER ENGINEERING AND SCIENCE,  63  (8): (2596-2612).  [PMID:]
6. Yong Zhu, Hailun Li, Huiran Jin, Jingrui Ma, Zhandong Ye, Bingmin Wu, Ying Zhang, Qingping Xiong, Shijie Ding, Jing Chen, Song Huang.  (2023)  An efficient and green separation method of total alkaloids by resorcinol-formaldehyde aerogel during extraction of Coptis chinensis.  INDUSTRIAL CROPS AND PRODUCTS,  195  (116438).  [PMID:]
7. Huang Xuemei, Liu Xiaojing, Lin Xiaoyu, Yuan Zhihua, Zhang Yaozhi, Wang Zhijia, Pi Wenmin, Zhao Haoqiang, Lei Haimin, Wang Penglong.  (2022)  Thermodynamics driving phytochemical self-assembly morphological change and efficacy enhancement originated from single and co-decoction of traditional chinese medicine.  JOURNAL OF NANOBIOTECHNOLOGY,  20  (1): (1-15).  [PMID:36510210]
8. Jingliang Wu, Cuiping Qi, Hao Wang, Qing Wang, Jingui Sun, Jinping Dong, Guohua Yu, Zhiqin Gao, Bo Zhang, Guixiang Tian.  (2022)  Curcumin and berberine co-loaded liposomes for anti-hepatocellular carcinoma therapy by blocking the cross-talk between hepatic stellate cells and tumor cells.  Frontiers in Pharmacology,  13  (961788).  [PMID:36188590]
9. Tingting Zhao, Qin Zhang, Feng Cang, Shilong Wu, Yu Jiang, Qiyao Zhao, Yifan Zhou, Xiaomeng Qu, Xuesong Zhang, Yushen Jin, Yanyan Li, Yujie Fu.  (2022)  Yolk-shell shaped Au-Bi2S3 heterostructure nanoparticles for controlled drug release and combined tumor therapy.  NANOTECHNOLOGY,  33  (45): (455103).  [PMID:35914421]
10. Xingxing Feng, Qi Xie, Hongbo Xu, Tiantian Zhang, Xiaonan Li, Yinmei Tian, Hongbing Lan, Li Kong, Zhiping Zhang.  (2022)  Yeast Microcapsule Mediated Natural Products Delivery for Treating Ulcerative Colitis through Anti-Inflammatory and Regulation of Macrophage Polarization.  ACS Applied Materials & Interfaces,  14  (27): (31085–31098).  [PMID:35770618]
11. Li Mo, She Jiang, Ma Louyan, Ma Li, Ma Xiaorui, Zhai Jiajia.  (2022)  Berberine protects against palmitate induced beta cell injury via promoting mitophagy.  Genes & Genomics,  44  (7): (867-878).  [PMID:35633490]
12. Longfa Kou, Huirong Huang, Yingying Tang, Meng Sun, Yingtao Li, Jianing Wu, Shimin Zheng, Xinyu Zhao, Daosen Chen, Zucheng Luo, Xiaolei Zhang, Qing Yao, Ruijie Chen.  (2022)  Opsonized nanoparticles target and regulate macrophage polarization for osteoarthritis therapy: A trapping strategy.  JOURNAL OF CONTROLLED RELEASE,  347  (237).  [PMID:35489544]
13. Haofeng Hu, Fulin Luo, Qian Zhang, Ming Xu, Xin Chen, Zhihao Liu, Haodong Xu, Lei Wang, Fei Ye, Kui Zhang, Bin Chen, Song Zheng, Jia Jin.  (2022)  Berberine coated biocomposite hemostatic film based alginate as absorbable biomaterial for wound healing.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  209  (1731).  [PMID:35487376]
14. Yingxin Chen, Xiaotong Huang, Lu Li, Junxian Wu, Yongqi Guo, Yachao Yao, Lihua Zhou.  (2022)  Paper mill sludge-based carbon quantum dots as a specifically ratiometric fluorescent probe for the sensitive and selective detection of coptisine.  LUMINESCENCE,  37  (7): (1078-1086).  [PMID:35441456]
15. Jia-Man Liang, Fang Zhang, Yu-Lin Zhu, Xiao-Yan Deng, Xian-Ping Chen, Qiu-Ju Zhou, Ke-Jun Tan.  (2022)  One-pot hydrothermal synthesis of Si-doped carbon quantum dots with up-conversion fluorescence as fluorescent probes for dual-readout detection of berberine hydrochloride.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  275  (121139).  [PMID:35313173]
16. Qin Wang, Kai-Ni Wei, Shu-Zhen Huang, Qing Tang, Zhu Tao, Ying Huang.  (2021)  “Turn-Off” Supramolecular Fluorescence Array Sensor for Heavy Metal Ion Identification.  ACS Omega,  (46): (31229–31235).  [PMID:34841166]
17. Miaomiao Qi, Xiang Liu, Ying Zhou, Haoyu Wang, Ying Zhao, Jing Ren, Jin Xiang.  (2021)  Berberine Inhibits MDA-MB-231 Cells as an Agonist of G Protein-Coupled Estrogen Receptor 1.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  22  (21): (11466).  [PMID:34768896]

References

1. Huang C et al..  (2020)  Berberine inhibits epithelial-mesenchymal transition and promotes apoptosis of tumour-associated fibroblast-induced colonic epithelial cells through regulation of TGF-ß signalling..  J Cell Commun Signal,  14  (53-66).  [PMID:31399854]
2. Huang C et al..  (2018)  Berberine reversed the epithelial-mesenchymal transition of normal colonic epithelial cells induced by SW480 cells through regulating the important components in the TGF-ß pathway..  J Cell Physiol,      [PMID:30536375]
3. Wei Ming Liu, Hui Yun Zhou, Li Jun Ren, Jia Jia Yang, Pei Yan Hao, Jia Nan Tong, Ya Wei Chen, Jun Liang Chen, Hyun Jin Park.  (2023)  Optimization, Characterization, Molecular Docking, and In Vitro Release of BBH/Lysine-β-cyclodextrin Inclusion Complex.  ChemistrySelect,  (45): (e202303620).  [PMID:11076860]
4. Gang Liu, Fengli Gao, Xiupei Yang, Jingyi Zhang, Suling Yang, Yuanyuan Li, Lin Liu.  (2023)  Aggregation-induced emission for the detection of peptide ligases with improving ligation efficiency.  ANALYTICA CHIMICA ACTA,  1284  (7): (341994).  [PMID:37996157]
5. Junpeng Sun, Xiaobang Liu, Jiaqun Du, Jinyu An, Yingqiao Li, Yu Hu, Shuai Cheng, Ying Xiong, Yanan Yu, He Tian, Xifan Mei, Chao Wu.  (2023)  Manganese-doped albumin-gelatin composite nanogel loaded with berberine applied to the treatment of gouty arthritis in rats via a SPARC-dependent mechanism.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  253  (5): (126999).  [PMID:37730000]
6. Kexin Zhang, Jiaxin Zhu, Ruyi Wang, Wanfang Zhu, Zhongtao Zhang, Liangping Gong, Feng Feng, Wenyuan Liu, Lingfei Han, Wei Qu.  (2023)  Mitochondria-anchoring self-assembled nanoparticles for multi-path energy depletion: A “nano bomb” in chemo-co-starvation therapy.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  642  (123180).  [PMID:37364784]
7. Chengde Liu, Wanting Du, Luyao Jiang, Yizheng Li, Cheng Liu, Xigao Jian.  (2023)  Enhanced antibacterial and adhesive properties of chitosan/gelatin hydrogel containing berberine hydrochloride and prepolymerized gallic acid exhibiting aggregation-induced emission.  POLYMER ENGINEERING AND SCIENCE,  63  (8): (2596-2612).  [PMID:]
8. Yong Zhu, Hailun Li, Huiran Jin, Jingrui Ma, Zhandong Ye, Bingmin Wu, Ying Zhang, Qingping Xiong, Shijie Ding, Jing Chen, Song Huang.  (2023)  An efficient and green separation method of total alkaloids by resorcinol-formaldehyde aerogel during extraction of Coptis chinensis.  INDUSTRIAL CROPS AND PRODUCTS,  195  (116438).  [PMID:]
9. Huang Xuemei, Liu Xiaojing, Lin Xiaoyu, Yuan Zhihua, Zhang Yaozhi, Wang Zhijia, Pi Wenmin, Zhao Haoqiang, Lei Haimin, Wang Penglong.  (2022)  Thermodynamics driving phytochemical self-assembly morphological change and efficacy enhancement originated from single and co-decoction of traditional chinese medicine.  JOURNAL OF NANOBIOTECHNOLOGY,  20  (1): (1-15).  [PMID:36510210]
10. Jingliang Wu, Cuiping Qi, Hao Wang, Qing Wang, Jingui Sun, Jinping Dong, Guohua Yu, Zhiqin Gao, Bo Zhang, Guixiang Tian.  (2022)  Curcumin and berberine co-loaded liposomes for anti-hepatocellular carcinoma therapy by blocking the cross-talk between hepatic stellate cells and tumor cells.  Frontiers in Pharmacology,  13  (961788).  [PMID:36188590]
11. Tingting Zhao, Qin Zhang, Feng Cang, Shilong Wu, Yu Jiang, Qiyao Zhao, Yifan Zhou, Xiaomeng Qu, Xuesong Zhang, Yushen Jin, Yanyan Li, Yujie Fu.  (2022)  Yolk-shell shaped Au-Bi2S3 heterostructure nanoparticles for controlled drug release and combined tumor therapy.  NANOTECHNOLOGY,  33  (45): (455103).  [PMID:35914421]
12. Xingxing Feng, Qi Xie, Hongbo Xu, Tiantian Zhang, Xiaonan Li, Yinmei Tian, Hongbing Lan, Li Kong, Zhiping Zhang.  (2022)  Yeast Microcapsule Mediated Natural Products Delivery for Treating Ulcerative Colitis through Anti-Inflammatory and Regulation of Macrophage Polarization.  ACS Applied Materials & Interfaces,  14  (27): (31085–31098).  [PMID:35770618]
13. Li Mo, She Jiang, Ma Louyan, Ma Li, Ma Xiaorui, Zhai Jiajia.  (2022)  Berberine protects against palmitate induced beta cell injury via promoting mitophagy.  Genes & Genomics,  44  (7): (867-878).  [PMID:35633490]
14. Longfa Kou, Huirong Huang, Yingying Tang, Meng Sun, Yingtao Li, Jianing Wu, Shimin Zheng, Xinyu Zhao, Daosen Chen, Zucheng Luo, Xiaolei Zhang, Qing Yao, Ruijie Chen.  (2022)  Opsonized nanoparticles target and regulate macrophage polarization for osteoarthritis therapy: A trapping strategy.  JOURNAL OF CONTROLLED RELEASE,  347  (237).  [PMID:35489544]
15. Haofeng Hu, Fulin Luo, Qian Zhang, Ming Xu, Xin Chen, Zhihao Liu, Haodong Xu, Lei Wang, Fei Ye, Kui Zhang, Bin Chen, Song Zheng, Jia Jin.  (2022)  Berberine coated biocomposite hemostatic film based alginate as absorbable biomaterial for wound healing.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  209  (1731).  [PMID:35487376]
16. Yingxin Chen, Xiaotong Huang, Lu Li, Junxian Wu, Yongqi Guo, Yachao Yao, Lihua Zhou.  (2022)  Paper mill sludge-based carbon quantum dots as a specifically ratiometric fluorescent probe for the sensitive and selective detection of coptisine.  LUMINESCENCE,  37  (7): (1078-1086).  [PMID:35441456]
17. Jia-Man Liang, Fang Zhang, Yu-Lin Zhu, Xiao-Yan Deng, Xian-Ping Chen, Qiu-Ju Zhou, Ke-Jun Tan.  (2022)  One-pot hydrothermal synthesis of Si-doped carbon quantum dots with up-conversion fluorescence as fluorescent probes for dual-readout detection of berberine hydrochloride.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  275  (121139).  [PMID:35313173]
18. Qin Wang, Kai-Ni Wei, Shu-Zhen Huang, Qing Tang, Zhu Tao, Ying Huang.  (2021)  “Turn-Off” Supramolecular Fluorescence Array Sensor for Heavy Metal Ion Identification.  ACS Omega,  (46): (31229–31235).  [PMID:34841166]
19. Miaomiao Qi, Xiang Liu, Ying Zhou, Haoyu Wang, Ying Zhao, Jing Ren, Jin Xiang.  (2021)  Berberine Inhibits MDA-MB-231 Cells as an Agonist of G Protein-Coupled Estrogen Receptor 1.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  22  (21): (11466).  [PMID:34768896]

Solution Calculators