Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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B139120-50mg | 50mg | In stock | $133.90 | |
B139120-100mg | 100mg | In stock | $189.90 | |
B139120-500mg | 500mg | In stock | $316.90 | |
B139120-1g | 1g | In stock | $416.90 | |
B139120-5g | 5g | In stock | $1,665.90 |
Isoquinoline alkaloid. Apoptotic anticancer agent.
Synonyms | BBR | 5,6-DIHYDRO-9,10-DIMETHOXYBENZO(G)-1,3-BENZODIOXOLO(5,6-A)QUINOLIZINIUM CHLORIDE | Berbinium,8,13,13a-tetradehydro-9.10-dimethoxy-2,3-(methylene dioxy)-, chloride | MLS002153890 | NCGC00016526-02 | SW196403-2 | Berbinium, 7,8,13,13a-tetradehydro-9,1 |
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Specifications & Purity | ≥95% |
Biochemical and Physiological Mechanisms | An alkaloid with weak antibiotic properties. Substrate for MDR efflux pumps. Antimicrobial activities of berberine is potentiated by the MDR inhibitor 5′-methoxyhydnocarpin (5′-MHC). Berberine upregulates the expression of Pgp in hepatoma cells. Treatment |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Product Application: Berberine is an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme Cox-2 (cyclooxygenase-2) which is abundantly expressed in colon cancer cells. Also inhibits c-Jun (Activator Protein 1), a transcription factor that plays a critical role in inflammation and carcinogenesis. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties |
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IUPAC Name | 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene;chloride |
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INCHI | InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1 |
InChi Key | VKJGBAJNNALVAV-UHFFFAOYSA-M |
Canonical SMILES | COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-] |
Isomeric SMILES | COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-] |
PubChem CID | 12456 |
Molecular Weight | 371.81 |
Beilstein | 3836585 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
F2419122 | Certificate of Analysis | Mar 22, 2024 | B139120 |
F2419123 | Certificate of Analysis | Mar 22, 2024 | B139120 |
B2309262 | Certificate of Analysis | Feb 21, 2023 | B139120 |
B2309261 | Certificate of Analysis | Feb 21, 2023 | B139120 |
B2309302 | Certificate of Analysis | Feb 21, 2023 | B139120 |
B2309260 | Certificate of Analysis | Feb 20, 2023 | B139120 |
B2309274 | Certificate of Analysis | Feb 20, 2023 | B139120 |
Solubility | Soluble in DMSO (74 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and methanol. |
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Sensitivity | Hygroscopic;Moisture sensitive. |
Pictogram(s) | GHS08 |
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Signal | Warning |
Hazard Statements | H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. |
1. Wei Ming Liu, Hui Yun Zhou, Li Jun Ren, Jia Jia Yang, Pei Yan Hao, Jia Nan Tong, Ya Wei Chen, Jun Liang Chen, Hyun Jin Park. (2023) Optimization, Characterization, Molecular Docking, and In Vitro Release of BBH/Lysine-β-cyclodextrin Inclusion Complex. ChemistrySelect, 8 (45): (e202303620). [PMID:11076860] |
2. Gang Liu, Fengli Gao, Xiupei Yang, Jingyi Zhang, Suling Yang, Yuanyuan Li, Lin Liu. (2023) Aggregation-induced emission for the detection of peptide ligases with improving ligation efficiency. ANALYTICA CHIMICA ACTA, 1284 (7): (341994). [PMID:37996157] |
3. Junpeng Sun, Xiaobang Liu, Jiaqun Du, Jinyu An, Yingqiao Li, Yu Hu, Shuai Cheng, Ying Xiong, Yanan Yu, He Tian, Xifan Mei, Chao Wu. (2023) Manganese-doped albumin-gelatin composite nanogel loaded with berberine applied to the treatment of gouty arthritis in rats via a SPARC-dependent mechanism. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 253 (5): (126999). [PMID:37730000] |
4. Kexin Zhang, Jiaxin Zhu, Ruyi Wang, Wanfang Zhu, Zhongtao Zhang, Liangping Gong, Feng Feng, Wenyuan Liu, Lingfei Han, Wei Qu. (2023) Mitochondria-anchoring self-assembled nanoparticles for multi-path energy depletion: A “nano bomb” in chemo-co-starvation therapy. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 642 (123180). [PMID:37364784] |
5. Chengde Liu, Wanting Du, Luyao Jiang, Yizheng Li, Cheng Liu, Xigao Jian. (2023) Enhanced antibacterial and adhesive properties of chitosan/gelatin hydrogel containing berberine hydrochloride and prepolymerized gallic acid exhibiting aggregation-induced emission. POLYMER ENGINEERING AND SCIENCE, 63 (8): (2596-2612). [PMID:] |
6. Yong Zhu, Hailun Li, Huiran Jin, Jingrui Ma, Zhandong Ye, Bingmin Wu, Ying Zhang, Qingping Xiong, Shijie Ding, Jing Chen, Song Huang. (2023) An efficient and green separation method of total alkaloids by resorcinol-formaldehyde aerogel during extraction of Coptis chinensis. INDUSTRIAL CROPS AND PRODUCTS, 195 (116438). [PMID:] |
7. Huang Xuemei, Liu Xiaojing, Lin Xiaoyu, Yuan Zhihua, Zhang Yaozhi, Wang Zhijia, Pi Wenmin, Zhao Haoqiang, Lei Haimin, Wang Penglong. (2022) Thermodynamics driving phytochemical self-assembly morphological change and efficacy enhancement originated from single and co-decoction of traditional chinese medicine. JOURNAL OF NANOBIOTECHNOLOGY, 20 (1): (1-15). [PMID:36510210] |
8. Jingliang Wu, Cuiping Qi, Hao Wang, Qing Wang, Jingui Sun, Jinping Dong, Guohua Yu, Zhiqin Gao, Bo Zhang, Guixiang Tian. (2022) Curcumin and berberine co-loaded liposomes for anti-hepatocellular carcinoma therapy by blocking the cross-talk between hepatic stellate cells and tumor cells. Frontiers in Pharmacology, 13 (961788). [PMID:36188590] |
9. Tingting Zhao, Qin Zhang, Feng Cang, Shilong Wu, Yu Jiang, Qiyao Zhao, Yifan Zhou, Xiaomeng Qu, Xuesong Zhang, Yushen Jin, Yanyan Li, Yujie Fu. (2022) Yolk-shell shaped Au-Bi2S3 heterostructure nanoparticles for controlled drug release and combined tumor therapy. NANOTECHNOLOGY, 33 (45): (455103). [PMID:35914421] |
10. Xingxing Feng, Qi Xie, Hongbo Xu, Tiantian Zhang, Xiaonan Li, Yinmei Tian, Hongbing Lan, Li Kong, Zhiping Zhang. (2022) Yeast Microcapsule Mediated Natural Products Delivery for Treating Ulcerative Colitis through Anti-Inflammatory and Regulation of Macrophage Polarization. ACS Applied Materials & Interfaces, 14 (27): (31085–31098). [PMID:35770618] |
11. Li Mo, She Jiang, Ma Louyan, Ma Li, Ma Xiaorui, Zhai Jiajia. (2022) Berberine protects against palmitate induced beta cell injury via promoting mitophagy. Genes & Genomics, 44 (7): (867-878). [PMID:35633490] |
12. Longfa Kou, Huirong Huang, Yingying Tang, Meng Sun, Yingtao Li, Jianing Wu, Shimin Zheng, Xinyu Zhao, Daosen Chen, Zucheng Luo, Xiaolei Zhang, Qing Yao, Ruijie Chen. (2022) Opsonized nanoparticles target and regulate macrophage polarization for osteoarthritis therapy: A trapping strategy. JOURNAL OF CONTROLLED RELEASE, 347 (237). [PMID:35489544] |
13. Haofeng Hu, Fulin Luo, Qian Zhang, Ming Xu, Xin Chen, Zhihao Liu, Haodong Xu, Lei Wang, Fei Ye, Kui Zhang, Bin Chen, Song Zheng, Jia Jin. (2022) Berberine coated biocomposite hemostatic film based alginate as absorbable biomaterial for wound healing. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 209 (1731). [PMID:35487376] |
14. Yingxin Chen, Xiaotong Huang, Lu Li, Junxian Wu, Yongqi Guo, Yachao Yao, Lihua Zhou. (2022) Paper mill sludge-based carbon quantum dots as a specifically ratiometric fluorescent probe for the sensitive and selective detection of coptisine. LUMINESCENCE, 37 (7): (1078-1086). [PMID:35441456] |
15. Jia-Man Liang, Fang Zhang, Yu-Lin Zhu, Xiao-Yan Deng, Xian-Ping Chen, Qiu-Ju Zhou, Ke-Jun Tan. (2022) One-pot hydrothermal synthesis of Si-doped carbon quantum dots with up-conversion fluorescence as fluorescent probes for dual-readout detection of berberine hydrochloride. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 275 (121139). [PMID:35313173] |
16. Qin Wang, Kai-Ni Wei, Shu-Zhen Huang, Qing Tang, Zhu Tao, Ying Huang. (2021) “Turn-Off” Supramolecular Fluorescence Array Sensor for Heavy Metal Ion Identification. ACS Omega, 6 (46): (31229–31235). [PMID:34841166] |
17. Miaomiao Qi, Xiang Liu, Ying Zhou, Haoyu Wang, Ying Zhao, Jing Ren, Jin Xiang. (2021) Berberine Inhibits MDA-MB-231 Cells as an Agonist of G Protein-Coupled Estrogen Receptor 1. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22 (21): (11466). [PMID:34768896] |
1. Huang C et al.. (2020) Berberine inhibits epithelial-mesenchymal transition and promotes apoptosis of tumour-associated fibroblast-induced colonic epithelial cells through regulation of TGF-ß signalling.. J Cell Commun Signal, 14 (53-66). [PMID:31399854] |
2. Huang C et al.. (2018) Berberine reversed the epithelial-mesenchymal transition of normal colonic epithelial cells induced by SW480 cells through regulating the important components in the TGF-ß pathway.. J Cell Physiol, [PMID:30536375] |
3. Wei Ming Liu, Hui Yun Zhou, Li Jun Ren, Jia Jia Yang, Pei Yan Hao, Jia Nan Tong, Ya Wei Chen, Jun Liang Chen, Hyun Jin Park. (2023) Optimization, Characterization, Molecular Docking, and In Vitro Release of BBH/Lysine-β-cyclodextrin Inclusion Complex. ChemistrySelect, 8 (45): (e202303620). [PMID:11076860] |
4. Gang Liu, Fengli Gao, Xiupei Yang, Jingyi Zhang, Suling Yang, Yuanyuan Li, Lin Liu. (2023) Aggregation-induced emission for the detection of peptide ligases with improving ligation efficiency. ANALYTICA CHIMICA ACTA, 1284 (7): (341994). [PMID:37996157] |
5. Junpeng Sun, Xiaobang Liu, Jiaqun Du, Jinyu An, Yingqiao Li, Yu Hu, Shuai Cheng, Ying Xiong, Yanan Yu, He Tian, Xifan Mei, Chao Wu. (2023) Manganese-doped albumin-gelatin composite nanogel loaded with berberine applied to the treatment of gouty arthritis in rats via a SPARC-dependent mechanism. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 253 (5): (126999). [PMID:37730000] |
6. Kexin Zhang, Jiaxin Zhu, Ruyi Wang, Wanfang Zhu, Zhongtao Zhang, Liangping Gong, Feng Feng, Wenyuan Liu, Lingfei Han, Wei Qu. (2023) Mitochondria-anchoring self-assembled nanoparticles for multi-path energy depletion: A “nano bomb” in chemo-co-starvation therapy. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 642 (123180). [PMID:37364784] |
7. Chengde Liu, Wanting Du, Luyao Jiang, Yizheng Li, Cheng Liu, Xigao Jian. (2023) Enhanced antibacterial and adhesive properties of chitosan/gelatin hydrogel containing berberine hydrochloride and prepolymerized gallic acid exhibiting aggregation-induced emission. POLYMER ENGINEERING AND SCIENCE, 63 (8): (2596-2612). [PMID:] |
8. Yong Zhu, Hailun Li, Huiran Jin, Jingrui Ma, Zhandong Ye, Bingmin Wu, Ying Zhang, Qingping Xiong, Shijie Ding, Jing Chen, Song Huang. (2023) An efficient and green separation method of total alkaloids by resorcinol-formaldehyde aerogel during extraction of Coptis chinensis. INDUSTRIAL CROPS AND PRODUCTS, 195 (116438). [PMID:] |
9. Huang Xuemei, Liu Xiaojing, Lin Xiaoyu, Yuan Zhihua, Zhang Yaozhi, Wang Zhijia, Pi Wenmin, Zhao Haoqiang, Lei Haimin, Wang Penglong. (2022) Thermodynamics driving phytochemical self-assembly morphological change and efficacy enhancement originated from single and co-decoction of traditional chinese medicine. JOURNAL OF NANOBIOTECHNOLOGY, 20 (1): (1-15). [PMID:36510210] |
10. Jingliang Wu, Cuiping Qi, Hao Wang, Qing Wang, Jingui Sun, Jinping Dong, Guohua Yu, Zhiqin Gao, Bo Zhang, Guixiang Tian. (2022) Curcumin and berberine co-loaded liposomes for anti-hepatocellular carcinoma therapy by blocking the cross-talk between hepatic stellate cells and tumor cells. Frontiers in Pharmacology, 13 (961788). [PMID:36188590] |
11. Tingting Zhao, Qin Zhang, Feng Cang, Shilong Wu, Yu Jiang, Qiyao Zhao, Yifan Zhou, Xiaomeng Qu, Xuesong Zhang, Yushen Jin, Yanyan Li, Yujie Fu. (2022) Yolk-shell shaped Au-Bi2S3 heterostructure nanoparticles for controlled drug release and combined tumor therapy. NANOTECHNOLOGY, 33 (45): (455103). [PMID:35914421] |
12. Xingxing Feng, Qi Xie, Hongbo Xu, Tiantian Zhang, Xiaonan Li, Yinmei Tian, Hongbing Lan, Li Kong, Zhiping Zhang. (2022) Yeast Microcapsule Mediated Natural Products Delivery for Treating Ulcerative Colitis through Anti-Inflammatory and Regulation of Macrophage Polarization. ACS Applied Materials & Interfaces, 14 (27): (31085–31098). [PMID:35770618] |
13. Li Mo, She Jiang, Ma Louyan, Ma Li, Ma Xiaorui, Zhai Jiajia. (2022) Berberine protects against palmitate induced beta cell injury via promoting mitophagy. Genes & Genomics, 44 (7): (867-878). [PMID:35633490] |
14. Longfa Kou, Huirong Huang, Yingying Tang, Meng Sun, Yingtao Li, Jianing Wu, Shimin Zheng, Xinyu Zhao, Daosen Chen, Zucheng Luo, Xiaolei Zhang, Qing Yao, Ruijie Chen. (2022) Opsonized nanoparticles target and regulate macrophage polarization for osteoarthritis therapy: A trapping strategy. JOURNAL OF CONTROLLED RELEASE, 347 (237). [PMID:35489544] |
15. Haofeng Hu, Fulin Luo, Qian Zhang, Ming Xu, Xin Chen, Zhihao Liu, Haodong Xu, Lei Wang, Fei Ye, Kui Zhang, Bin Chen, Song Zheng, Jia Jin. (2022) Berberine coated biocomposite hemostatic film based alginate as absorbable biomaterial for wound healing. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 209 (1731). [PMID:35487376] |
16. Yingxin Chen, Xiaotong Huang, Lu Li, Junxian Wu, Yongqi Guo, Yachao Yao, Lihua Zhou. (2022) Paper mill sludge-based carbon quantum dots as a specifically ratiometric fluorescent probe for the sensitive and selective detection of coptisine. LUMINESCENCE, 37 (7): (1078-1086). [PMID:35441456] |
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