Berberine chloride form - ≥95%, high purity , CAS No.633-65-8

Item Number

B139120

Grouped product items
SKU	Size	Availability	Price
B139120-50mg	50mg	In stock	$133.90
B139120-100mg	100mg	In stock	$189.90
B139120-500mg	500mg	In stock	$316.90
B139120-1g	1g	In stock	$416.90
B139120-5g	5g	In stock	$1,665.90

Isoquinoline alkaloid. Apoptotic anticancer agent.

Basic Description

Synonyms	berberine chloride\|Berberine hydrochloride\|633-65-8\|Natural Yellow 18\|Benzodioxide\|Berberinium chloride\|Berberine HCl\|Berberine (chloride)\|Berberinum\|NSC-163088\|9,10-dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium chloride\|MF
Specifications & Purity	≥95%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Product Description	Product Application: Berberine is an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme Cox-2 (cyclooxygenase-2) which is abundantly expressed in colon cancer cells. Also inhibits c-Jun (Activator Protein 1), a transcription factor that plays a critical role in inflammation and carcinogenesis. Fluorescent stain for heparin in mast cells. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties

Names and Identifiers

IUPAC Name	16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene;chloride
INCHI	InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1
InChi Key	VKJGBAJNNALVAV-UHFFFAOYSA-M
Canonical SMILES	COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]
Isomeric SMILES	COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]
PubChem CID	12456
Molecular Weight	371.81
Beilstein	3836585

Certificates

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7 results found

Lot Number	Certificate Type	Date	Item
F2419122	Certificate of Analysis	Mar 22, 2024	B139120
F2419123	Certificate of Analysis	Mar 22, 2024	B139120
B2309262	Certificate of Analysis	Feb 21, 2023	B139120
B2309261	Certificate of Analysis	Feb 21, 2023	B139120
B2309302	Certificate of Analysis	Feb 21, 2023	B139120
B2309260	Certificate of Analysis	Feb 20, 2023	B139120
B2309274	Certificate of Analysis	Feb 20, 2023	B139120

Solubility

Soluble in DMSO (74 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and methanol.

Sensitivity

Hygroscopic;Moisture sensitive.

Safety and Hazards(GHS)

Pictogram(s)	GHS08
Signal	Warning
Hazard Statements	H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice.

References

1. Huang C et al.. (2020) Berberine inhibits epithelial-mesenchymal transition and promotes apoptosis of tumour-associated fibroblast-induced colonic epithelial cells through regulation of TGF-ß signalling.. J Cell Commun Signal, 14 (53-66). [PMID:31399854]
2. Huang C et al.. (2018) Berberine reversed the epithelial-mesenchymal transition of normal colonic epithelial cells induced by SW480 cells through regulating the important components in the TGF-ß pathway.. J Cell Physiol, [PMID:30536375]

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Basic Description