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SKU | Size | Availability | Price | Qty |
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S276273-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $137.90 |
Cell-permeable, reversible β-secretase inhibitor
Specifications & Purity | ≥95% |
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Biochemical and Physiological Mechanisms | Cell-permeable, reversible β-secretase inhibitor. Corresponds to the VNL-DA cleavage site on APP. Inhibits Aβ formation (IC 50 values are 0.7 and 2.5 µM for Aβtotal and Aβ1-42 respectively). Shows neuroprotective effects. |
Storage Temp | Protected from light,Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. |
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Acetylcholinesterase inhibitor | INHIBITOR | ALA220 | Acetylcholinesterase | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Acetylcholinesterase inhibitor | INHIBITOR | ALA220 | Acetylcholinesterase | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Acetylcholinesterase inhibitor | INHIBITOR | ALA220 | Acetylcholinesterase | SINGLE PROTEIN | Homo sapiens | ||
Acetylcholinesterase inhibitor | INHIBITOR | ALA220 | Acetylcholinesterase | SINGLE PROTEIN | Homo sapiens | ||
Acetylcholinesterase inhibitor | INHIBITOR | ALA220 | Acetylcholinesterase | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Acetylcholinesterase inhibitor | INHIBITOR | ALA220 | Acetylcholinesterase | SINGLE PROTEIN | Homo sapiens | ||
Acetylcholinesterase inhibitor | INHIBITOR | ALA220 | Acetylcholinesterase | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Acetylcholinesterase inhibitor | INHIBITOR | ALA220 | Acetylcholinesterase | SINGLE PROTEIN | Homo sapiens | ||
Acetylcholinesterase inhibitor | INHIBITOR | ALA220 | Acetylcholinesterase | SINGLE PROTEIN | Homo sapiens | PubMed: [1] | |
Acetylcholinesterase inhibitor | INHIBITOR | ALA220 | Acetylcholinesterase | SINGLE PROTEIN | Homo sapiens | FDA: [1] |
Canonical SMILES | CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1 |
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Isomeric SMILES | CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1 |
PubChem CID | 10253763 |
Molecular Weight | 461.6 |
Solubility | Soluble in DMSO to 10 mM |
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Sensitivity | light sensitive |
1. Dickens JA et al.. (2022) Novel insights into surfactant protein C trafficking revealed through the study of a pathogenic mutant.. Eur Respir J, 59 [PMID:34049951] |