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beta Tubulin Mouse mAb - Primary antibody, specific to beta tubulin, IgG3

Azide Free
Carrier Free
ExactAb™
Validated
高性能
1.0mg/mL

Features and benefits

Short Overview:
mAb (AB01/1E7); Mouse anti Human beta tubulin Antibody; WB, Flow, ELISA; Unconjugated
Species reactivity(Reacts with): Human,Mouse,Rat
Isotype: IgG3

Application:

Flow Cytometry
WB

Item Number

Ab179921

Grouped product items
SKU	Size	Availability	Price
Ab179921-10μl (Trial Size) Apply for free trial size（?） Every year, as a valued customer, you have the exclusive opportunity to explore and enjoy three different trial products of your choice, absolutely free!	10μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$66.90
Ab179921-20μl	20μl	In stock	$99.90
Ab179921-50μl	50μl	In stock	$199.90
Ab179921-100μl	100μl	In stock	$299.90
Ab179921-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,499.90

mAb (AB01/1E7); Mouse anti Human beta tubulin Antibody; WB, Flow, ELISA; Unconjugated

View related series

Accession#:P07437 beta Tubulin Gene ID:203068 TUBB

Basic Description

Product Name	beta Tubulin Mouse mAb - Primary antibody, specific to beta tubulin, IgG3
Synonyms	Beta 4 tubulin antibody; Beta 5 tubulin antibody; beta Ib tubulin antibody; Beta1 tubulin antibody; Class I beta tubulin antibody; M40 antibody; MGC117247antibody; MGC16435 antibody; OK/SW cl.56 antibody; OK/SWcl.56 antibody; TBB5_HUMAN antibody; TUBB 1 a
Specifications & Purity	ExactAb™, Validated, Carrier Free, Azide Free, High performance, 1.0mg/mL
Host species	Mouse
Specificity	beta tubulin
Immunogen	Recombinant human beta tubulin
Positive Control	WB: HeLa, A431, HEK293, MCF7, NIH3T3 and C6 whole cell lysates Flow: HeLa cells
Conjugation	Unconjugated
Grade	Azide Free, Carrier Free, ExactAb™, Validated, 高性能
Product Description	Application WB: 1/2,000-1/10,0000; Predicted molecular weight: 50 kDa Flow: 0.002 μg/mL - 0.25 μg/mL Protein Function: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

Product Properties

Isotype	IgG3
Light Chain Type	kappa
SDS-PAGE	150 kDa
Purification Method	Protein A purified
Form	Liquid
Concentration	1.0mg/mL
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.

Images

beta Tubulin Mouse mAb (Ab179921) - Western Blot
All lanes: beta Tubulin Antibody (Ab179921) at 0.05 μg/mL
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab138040) at 1/20000 dilution

Predicted band size: 50.0 kDa
Observed band size: 50.0 kDa
Exposure time: 90.0 s

beta Tubulin Mouse mAb (Ab179921) - Flow Cytometry
Overlay histogram showing HeLa cells stained with beta Tubulin Mouse mAb (Ab179921) (Red). Cells were fixed and permeabilized with 100% methanol. A Goat Anti-Mouse IgG H&L (FITC) (Ab156254) was used as the secondary antibody. Unlabeled sample (Black) was used as a negative control. The mouse IgG (Ab170221) was used as an isotype control (Blue).

Associated Targets

TUBB Tclin Tubulin beta chain 0 Activities

Discover Target: TUBB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Application

Application	Dilution info
WB	1/2,000-1/10,0000; Predicted molecular weight: 50 kDa
Flow	0.002 μg/mL - 0.25 μg/mL

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot Number	Certificate Type	Date	Item
ZJ23F1202057	Certificate of Analysis	Dec 13, 2023	Ab179921
ZJ23F1202058	Certificate of Analysis	Dec 13, 2023	Ab179921
ZJ23F1202059	Certificate of Analysis	Dec 13, 2023	Ab179921

References

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56. Fourest-Lieuvin, Anne A and 6 more authors.. (2006) Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1.. Molecular biology of the cell, [PMID:16371510]
57. Kurtzberg, Leslie S LS and 8 more authors.. (2009) Bone marrow CFU-GM and human tumor xenograft efficacy of three tubulin binding agents.. Cancer chemotherapy and pharmacology, [PMID:19277662]
58. Rogowski, Krzysztof K and 10 more authors.. (2009) Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation.. Cell, (12): [PMID:19524510]
59. Sève, P P and Dumontet, C C.. (2010) [Class III beta tubulin expression in nonsmall cell lung cancer].. Revue des maladies respiratoires, [PMID:20403547]
60. Finkelstein, Yaron Y and 8 more authors.. (2010) Colchicine poisoning: the dark side of an ancient drug.. Clinical toxicology (Philadelphia, Pa.), [PMID:20586571]
61. Kinzel, Doris D and 10 more authors.. (2010) Pitchfork regulates primary cilia disassembly and left-right asymmetry.. Developmental cell, (20): [PMID:20643351]
62. Anbalagan, Muralidharan M and 8 more authors.. (2012) Peptidomimetic Src/pretubulin inhibitor KX-01 alone and in combination with paclitaxel suppresses growth, metastasis in human ER/PR/HER2-negative tumor xenografts.. Molecular cancer therapeutics, [PMID:22784709]
63. Breuss, Martin M and 22 more authors.. (2012) Mutations in the β-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities.. Cell reports, (27): [PMID:23246003]
64. Li, Donghui D, Dammer, Eric B EB, Lucki, Natasha C NC and Sewer, Marion B MB.. (2013) cAMP-stimulated phosphorylation of diaphanous 1 regulates protein stability and interaction with binding partners in adrenocortical cells.. Molecular biology of the cell, [PMID:23325789]
65. Isrie, Mala M and 23 more authors.. (2015) Mutations in Either TUBB or MAPRE2 Cause Circumferential Skin Creases Kunze Type.. American journal of human genetics, (3): [PMID:26637975]
66. Valenstein, Max L ML and Roll-Mecak, Antonina A.. (2016) Graded Control of Microtubule Severing by Tubulin Glutamylation.. Cell, (25): [PMID:26875866]
67. Waight, Andrew B and 5 more authors.. (2016) Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics.. PloS one, [PMID:27518442]
68. Niu, Lu and 7 more authors.. (2019) Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of β-tubulin explains KXO1's low clinical toxicity.. The Journal of biological chemistry, (29): [PMID:31628188]

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