Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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B125743-50mg | 50mg | In stock | $35.90 | |
B125743-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $49.90 | |
B125743-250mg | 250mg | In stock | $263.90 | |
B125743-1g | 1g | In stock | $947.90 |
Potent RXR agonist
Synonyms | Bexarotene | 153559-49-0 | Targretin | Targrexin | Targretyn | LGD1069 | Targret | LGD 1069 | bexaroteno | bexarotenum | LGD-1069 | LG100069 | 166175-31-1 | DTXSID1040619 | LG 1069 | HSDB 7453 | 4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid | p-(1-(5,6,7 |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Bexarotene (tradenamed Targretin) is an oral antineoplastic agent indicated by the U.S. Food and Drug Administration (FDA) (in 2000) for cutaneous T cell lymphoma. Bexarotene (tradenamed Targretin) has been used off-label for lung cancer, breast cancer, a |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST, ANTAGONIST |
Mechanism of action | Retinoid X receptor agonist |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Bexarotene (Targretin) is a selective RXR agonist approved for the treatment of CTCL. |
ALogP | 7.6 |
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IUPAC Name | 4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic acid |
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INCHI | InChI=1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26) |
InChi Key | NAVMQTYZDKMPEU-UHFFFAOYSA-N |
Canonical SMILES | CC1=CC2=C(C=C1C(=C)C3=CC=C(C=C3)C(=O)O)C(CCC2(C)C)(C)C |
Isomeric SMILES | CC1=CC2=C(C=C1C(=C)C3=CC=C(C=C3)C(=O)O)C(CCC2(C)C)(C)C |
WGK Germany | 3 |
PubChem CID | 82146 |
Molecular Weight | 348.48 |
DrugBank Ligand | DB00307 |
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ChEBI | CHEBI:50859 |
PubChem CID | 82146 |
ChEMBL Ligand | CHEMBL1023 |
BindingDB Ligand | 50032675 |
Wikipedia | Bexarotene |
CAS Registry No. | 153559-49-0 |
NURSA Ligand | 10.1621/PXQH4UEUBU |
RCSB PDB Ligand | 9RA |
PEP | bexarotene |
DrugCentral Ligand | 361 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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G1824280 | Certificate of Analysis | Dec 12, 2023 | B125743 |
K2314279 | Certificate of Analysis | Nov 02, 2023 | B125743 |
K2314280 | Certificate of Analysis | Nov 02, 2023 | B125743 |
K2314281 | Certificate of Analysis | Nov 02, 2023 | B125743 |
K2314282 | Certificate of Analysis | Nov 02, 2023 | B125743 |
F1601005 | Certificate of Analysis | Oct 18, 2023 | B125743 |
I2213251 | Certificate of Analysis | Sep 16, 2022 | B125743 |
Solubility | DMSO 8 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
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Sensitivity | Heat Sensitive |
Refractive Index | 1.56 |
Boil Point(°C) | 489.67° C at 760 mmHg |
Melt Point(°C) | 220-225℃ |
Pictogram(s) | GHS08, GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
Merck Index | 1194 |
1. Liu H et al.. (2019) Bexarotene Attenuates Focal Cerebral Ischemia-Reperfusion Injury via the Suppression of JNK/Caspase-3 Signaling Pathway.. Neurochem Res, 44 (12): (2809-2820). [PMID:31680194] |
2. Liu H et al.. (2022) iTRAQ-derived quantitative proteomics uncovers the neuroprotective property of bexarotene in a mice model of cerebral ischemia-reperfusion injury.. Saudi Pharm J, 30 (5): (585-594). [PMID:35693438] |