Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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B129520-1g | 1g | In stock | $25.90 | |
B129520-5g | 5g | In stock | $98.90 | |
B129520-10g | 10g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $177.90 | |
B129520-25g | 25g | In stock | $217.90 | |
B129520-100g | 100g | In stock | $783.90 | |
B129520-500g | 500g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $3,524.90 |
Pan-PPAR agonist
Synonyms | Bezafibrate [USAN:INN:BAN:JAN] | Difaterol | MLS001148205 | Opera_ID_376 | PEM | 2-[P-[2-P-CHLOROBENZAMIDO)ETHYL]PHENOXY]-2-METHYLPROPIONIC ACID | Bezalip Retard | BM15075 | BM-15075 | KBio2_007059 | Regadrin B | BEZAFIBRATE (EP MONOGRAPH) | Bezamerck | P |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Bezafibrate is a peroxisome proliferator and hypolipidaemic agent that is a derivative of clofibrate. Shown to be effective in preventing mammary tumors induced by radiation together with DES, possibly by reducing prolactin and triglyceride concentrations |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Peroxisome proliferator-activated receptor agonist |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Bezafibrate is the first clinically tested dual and pan-PPAR co-agonism. |
ALogP | 3.8 |
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IUPAC Name | 2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methylpropanoic acid |
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INCHI | InChI=1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24) |
InChi Key | IIBYAHWJQTYFKB-UHFFFAOYSA-N |
Canonical SMILES | CC(C)(C(=O)O)OC1=CC=C(C=C1)CCNC(=O)C2=CC=C(C=C2)Cl |
Isomeric SMILES | CC(C)(C(=O)O)OC1=CC=C(C=C1)CCNC(=O)C2=CC=C(C=C2)Cl |
WGK Germany | 1 |
RTECS | UE8755000 |
PubChem CID | 39042 |
Molecular Weight | 361.82 |
Reaxy-Rn | 4267656 |
PubChem CID | 39042 |
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DrugBank Ligand | DB01393 |
CAS Registry No. | 41859-67-0 |
ChEBI | CHEBI:47612 |
ChEMBL Ligand | CHEMBL264374 |
BindingDB Ligand | 28701 |
Wikipedia | Bezafibrate |
NURSA Ligand | 10.1621/N2ZUHQHU9O |
RCSB PDB Ligand | PEM |
PEP | bezafibrate |
DrugCentral Ligand | 362 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
I2209211 | Certificate of Analysis | Jun 05, 2024 | B129520 |
I2209212 | Certificate of Analysis | Jun 05, 2024 | B129520 |
I2209213 | Certificate of Analysis | Jun 05, 2024 | B129520 |
I2209214 | Certificate of Analysis | Jun 05, 2024 | B129520 |
L1713093 | Certificate of Analysis | May 11, 2023 | B129520 |
K1708028 | Certificate of Analysis | Apr 14, 2023 | B129520 |
D2114443 | Certificate of Analysis | Jan 17, 2023 | B129520 |
D2114447 | Certificate of Analysis | Jan 17, 2023 | B129520 |
D2114450 | Certificate of Analysis | Jan 17, 2023 | B129520 |
I2319044 | Certificate of Analysis | Jul 22, 2022 | B129520 |
Solubility | Soluble in DMSO (50 mg/ml), water (partly), methanol, ethanol (~3 mg/ml), and DMF (~30 mg/ml). |
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Melt Point(°C) | 183-186°C |
Pictogram(s) | GHS08, GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. |
WGK Germany | 1 |
RTECS | UE8755000 |
Reaxy-Rn | 4267656 |
Merck Index | 1195 |
1. Huimin Zhou, Zhiwei Qiu, Jin Zeng, Ruobin Dai, Zhiwei Wang. (2023) Ultra-permeable polyamide nanofiltration membrane modified by hydrophilic-hydrophobic alternated lignocellulosic nanofibrils for efficient water reuse. JOURNAL OF MEMBRANE SCIENCE, 688 (15): (122125). [PMID:10677542] |
2. Xuecong Qian, Shilong Wang, Haijun Cheng, Ziye Jia, Da Wang, Yandong Xie, Jinhao Duan, Yu Tian, Jun Ma. (2023) Mn(II) oxidation by the UV/chlorine system under near-neutral pH conditions: The important role of ClO· and ClO2. WATER RESEARCH, 246 (28): (120673). [PMID:37844341] |
3. Mingming Qi, Hui Zhong, Zhaoyan Cheng, Shujie Chen, Han Xiao, Jing Shang, Li Chen, Jianbo Sun. (2023) Discovery of NAFLD-Improving Agents by Promoting the Degradation of Keap1. JOURNAL OF MEDICINAL CHEMISTRY, [PMID:37386884] |
4. Tianhua He, Nikita Lykov, Xu Luo, Huiling Wang, Zhanxiang Du, Ziyi Chen, Shitian Chen, Lin Zhu, Ye Zhao, Chimeng Tzeng. (2023) Protective Effects of Lactobacillus gasseri against High-Cholesterol Diet-Induced Fatty Liver and Regulation of Host Gene Expression Profiles. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (3): (2053). [PMID:36768377] |
5. Ji Ma, Yang Deng, Tingting Yang, Maoru Li, Jing Shang. (2023) Esculetin Alleviates Nonalcoholic Fatty Liver Disease on High-Cholesterol-Diet-Induced Larval Zebrafish and FFA-Induced BRL-3A Hepatocyte. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (2): (1593). [PMID:36675107] |
6. Hui Su, Xudan Dou, Dandan Xu, Li Feng, Yongze Liu, Ziwen Du, Liqiu Zhang. (2022) Fe0-loaded superfine powdered activated carbon prepared by ball milling for synergistic adsorption and persulfate activation to remove aqueous carbamazepine. CHEMOSPHERE, 293 (133665). [PMID:35051510] |
7. Xiangyu Chen, Juanjuan Yao, Hongsen Dong, Mingjian Hong, Naiyun Gao, Zhi Zhang, Wenchao Jiang. (2021) Enhanced bezafibrate degradation and power generation via the simultaneous PMS activation in visible light photocatalytic fuel cell. WATER RESEARCH, 207 (117800). [PMID:34741902] |
1. Huimin Zhou, Zhiwei Qiu, Jin Zeng, Ruobin Dai, Zhiwei Wang. (2023) Ultra-permeable polyamide nanofiltration membrane modified by hydrophilic-hydrophobic alternated lignocellulosic nanofibrils for efficient water reuse. JOURNAL OF MEMBRANE SCIENCE, 688 (15): (122125). [PMID:10677542] |
2. Xuecong Qian, Shilong Wang, Haijun Cheng, Ziye Jia, Da Wang, Yandong Xie, Jinhao Duan, Yu Tian, Jun Ma. (2023) Mn(II) oxidation by the UV/chlorine system under near-neutral pH conditions: The important role of ClO· and ClO2. WATER RESEARCH, 246 (28): (120673). [PMID:37844341] |
3. Mingming Qi, Hui Zhong, Zhaoyan Cheng, Shujie Chen, Han Xiao, Jing Shang, Li Chen, Jianbo Sun. (2023) Discovery of NAFLD-Improving Agents by Promoting the Degradation of Keap1. JOURNAL OF MEDICINAL CHEMISTRY, [PMID:37386884] |
4. Tianhua He, Nikita Lykov, Xu Luo, Huiling Wang, Zhanxiang Du, Ziyi Chen, Shitian Chen, Lin Zhu, Ye Zhao, Chimeng Tzeng. (2023) Protective Effects of Lactobacillus gasseri against High-Cholesterol Diet-Induced Fatty Liver and Regulation of Host Gene Expression Profiles. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (3): (2053). [PMID:36768377] |
5. Ji Ma, Yang Deng, Tingting Yang, Maoru Li, Jing Shang. (2023) Esculetin Alleviates Nonalcoholic Fatty Liver Disease on High-Cholesterol-Diet-Induced Larval Zebrafish and FFA-Induced BRL-3A Hepatocyte. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (2): (1593). [PMID:36675107] |
6. Hui Su, Xudan Dou, Dandan Xu, Li Feng, Yongze Liu, Ziwen Du, Liqiu Zhang. (2022) Fe0-loaded superfine powdered activated carbon prepared by ball milling for synergistic adsorption and persulfate activation to remove aqueous carbamazepine. CHEMOSPHERE, 293 (133665). [PMID:35051510] |
7. Xiangyu Chen, Juanjuan Yao, Hongsen Dong, Mingjian Hong, Naiyun Gao, Zhi Zhang, Wenchao Jiang. (2021) Enhanced bezafibrate degradation and power generation via the simultaneous PMS activation in visible light photocatalytic fuel cell. WATER RESEARCH, 207 (117800). [PMID:34741902] |