Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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B423892-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $69.90 |
Pan-PPAR agonist
Synonyms | bezafibrate | 41859-67-0 | Bezalip | Cedur | Bezafibrat | Befizal | Bezafibrato | Bezafibratum | Sklerofibrat | Azufibrat | Bezatol | Bezatol SR | Bezafibratum [INN-Latin] | Bezafibrato [INN-Spanish] | BM-15.075 | LO 44 | Bezatol SR (TN) | BF-759 | CCRIS 9085 | BM 15075 | BM-15075 | BM 15.075 | 2-( |
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Specifications & Purity | Moligand™, 10mM in DMSO |
Biochemical and Physiological Mechanisms | Bezafibrate is a peroxisome proliferator and hypolipidaemic agent that is a derivative of clofibrate. Shown to be effective in preventing mammary tumors induced by radiation together with DES, possibly by reducing prolactin and triglyceride concentrations |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | Bezafibrate is the first clinically tested dual and pan-PPAR co-agonism. |
ALogP | 3.8 |
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IUPAC Name | 2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methylpropanoic acid |
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INCHI | InChI=1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24) |
InChi Key | IIBYAHWJQTYFKB-UHFFFAOYSA-N |
Canonical SMILES | CC(C)(C(=O)O)OC1=CC=C(C=C1)CCNC(=O)C2=CC=C(C=C2)Cl |
Isomeric SMILES | CC(C)(C(=O)O)OC1=CC=C(C=C1)CCNC(=O)C2=CC=C(C=C2)Cl |
WGK Germany | 1 |
RTECS | UE8755000 |
PubChem CID | 39042 |
Molecular Weight | 361.82 |
Reaxy-Rn | 4267656 |
Enter Lot Number to search for COA:
Melt Point(°C) | 183-186°C |
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Pictogram(s) | GHS08, GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. |
WGK Germany | 1 |
RTECS | UE8755000 |
Reaxy-Rn | 4267656 |
Merck Index | 1195 |
1. Huimin Zhou, Zhiwei Qiu, Jin Zeng, Ruobin Dai, Zhiwei Wang. (2023) Ultra-permeable polyamide nanofiltration membrane modified by hydrophilic-hydrophobic alternated lignocellulosic nanofibrils for efficient water reuse. JOURNAL OF MEMBRANE SCIENCE, 688 (15): (122125). [PMID:10677542] [10.1016/j.memsci.2023.122125] |
2. Xuecong Qian, Shilong Wang, Haijun Cheng, Ziye Jia, Da Wang, Yandong Xie, Jinhao Duan, Yu Tian, Jun Ma. (2023) Mn(II) oxidation by the UV/chlorine system under near-neutral pH conditions: The important role of ClO· and ClO2. WATER RESEARCH, 246 (28): (120673). [PMID:37844341] [10.1016/j.watres.2023.120673] |
3. Mingming Qi, Hui Zhong, Zhaoyan Cheng, Shujie Chen, Han Xiao, Jing Shang, Li Chen, Jianbo Sun. (2023) Discovery of NAFLD-Improving Agents by Promoting the Degradation of Keap1. JOURNAL OF MEDICINAL CHEMISTRY, [PMID:37386884] [10.1021/acs.jmedchem.3c00822] |
4. Tianhua He, Nikita Lykov, Xu Luo, Huiling Wang, Zhanxiang Du, Ziyi Chen, Shitian Chen, Lin Zhu, Ye Zhao, Chimeng Tzeng. (2023) Protective Effects of Lactobacillus gasseri against High-Cholesterol Diet-Induced Fatty Liver and Regulation of Host Gene Expression Profiles. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (3): (2053). [PMID:36768377] [10.3390/ijms24032053] |
5. Ji Ma, Yang Deng, Tingting Yang, Maoru Li, Jing Shang. (2023) Esculetin Alleviates Nonalcoholic Fatty Liver Disease on High-Cholesterol-Diet-Induced Larval Zebrafish and FFA-Induced BRL-3A Hepatocyte. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (2): (1593). [PMID:36675107] [10.3390/ijms24021593] |
6. Hui Su, Xudan Dou, Dandan Xu, Li Feng, Yongze Liu, Ziwen Du, Liqiu Zhang. (2022) Fe0-loaded superfine powdered activated carbon prepared by ball milling for synergistic adsorption and persulfate activation to remove aqueous carbamazepine. CHEMOSPHERE, 293 (133665). [PMID:35051510] [10.1016/j.chemosphere.2022.133665] |
7. Xiangyu Chen, Juanjuan Yao, Hongsen Dong, Mingjian Hong, Naiyun Gao, Zhi Zhang, Wenchao Jiang. (2021) Enhanced bezafibrate degradation and power generation via the simultaneous PMS activation in visible light photocatalytic fuel cell. WATER RESEARCH, 207 (117800). [PMID:34741902] [10.1016/j.watres.2021.117800] |
8. Yang Deng, Ji Ma, Xin Weng, Yuqin Wang, Maoru Li, Tingting Yang, Zhiyang Dou, Zhiqi Yin, Jing Shang. (2021) Kaempferol-3-O-Glucuronide Ameliorates Non-Alcoholic Steatohepatitis in High-Cholesterol-Diet-Induced Larval Zebrafish and HepG2 Cell Models via Regulating Oxidation Stress. Life-Basel, 11 (5): (445). [PMID:34069176] [10.3390/life11050445] |
9. Yang Guo, Erzhuo Zhao, Jun Wang, Xiaoyuan Zhang, Haiou Huang, Gang Yu, Yujue Wang. (2020) Comparison of emerging contaminant abatement by conventional ozonation, catalytic ozonation, O3/H2O2 and electro-peroxone processes. JOURNAL OF HAZARDOUS MATERIALS, 389 (121829). [PMID:31836369] [10.1016/j.jhazmat.2019.121829] |
10. Nadeem Muhammad, Dandan Guo, Yun Zhang, Azeem Intisar, Qamar Subhani, Muhammad Abdul Qadir, Hairong Cui. (2019) Online clean-up setup for the determination of non-fluorescent acidic pharmaceutical drugs in complex biological samples. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1126-1127 (121708). [PMID:31437773] [10.1016/j.jchromb.2019.06.035] |
11. Ji Ma, Hongli Yin, Maoru Li, Yang Deng, Owais Ahmad, Guohong Qin, Qiangqiang He, Jiajing Li, Kai Gao, Junyi Zhu, Bing Wang, Susu Wu, Tao Wang, Jing Shang. (2019) A Comprehensive Study of High Cholesterol Diet-Induced Larval Zebrafish Model: A Short-Time In Vivo Screening Method for Non-Alcoholic Fatty Liver Disease Drugs. International Journal of Biological Sciences, 15 (5): ( 973–983). [PMID:31182918] [10.7150/ijbs.30013] |
12. Shen Chang-shuai, Zhou Cai-rong. (2016) Investigation of the thermal decomposition kinetics of bezafibrate. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 126 (2): (959-967). [PMID:] [10.1007/s10973-016-5565-9] |
1. Huimin Zhou, Zhiwei Qiu, Jin Zeng, Ruobin Dai, Zhiwei Wang. (2023) Ultra-permeable polyamide nanofiltration membrane modified by hydrophilic-hydrophobic alternated lignocellulosic nanofibrils for efficient water reuse. JOURNAL OF MEMBRANE SCIENCE, 688 (15): (122125). [PMID:10677542] [10.1016/j.memsci.2023.122125] |
2. Xuecong Qian, Shilong Wang, Haijun Cheng, Ziye Jia, Da Wang, Yandong Xie, Jinhao Duan, Yu Tian, Jun Ma. (2023) Mn(II) oxidation by the UV/chlorine system under near-neutral pH conditions: The important role of ClO· and ClO2. WATER RESEARCH, 246 (28): (120673). [PMID:37844341] [10.1016/j.watres.2023.120673] |
3. Mingming Qi, Hui Zhong, Zhaoyan Cheng, Shujie Chen, Han Xiao, Jing Shang, Li Chen, Jianbo Sun. (2023) Discovery of NAFLD-Improving Agents by Promoting the Degradation of Keap1. JOURNAL OF MEDICINAL CHEMISTRY, [PMID:37386884] [10.1021/acs.jmedchem.3c00822] |
4. Tianhua He, Nikita Lykov, Xu Luo, Huiling Wang, Zhanxiang Du, Ziyi Chen, Shitian Chen, Lin Zhu, Ye Zhao, Chimeng Tzeng. (2023) Protective Effects of Lactobacillus gasseri against High-Cholesterol Diet-Induced Fatty Liver and Regulation of Host Gene Expression Profiles. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (3): (2053). [PMID:36768377] [10.3390/ijms24032053] |
5. Ji Ma, Yang Deng, Tingting Yang, Maoru Li, Jing Shang. (2023) Esculetin Alleviates Nonalcoholic Fatty Liver Disease on High-Cholesterol-Diet-Induced Larval Zebrafish and FFA-Induced BRL-3A Hepatocyte. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (2): (1593). [PMID:36675107] [10.3390/ijms24021593] |
6. Hui Su, Xudan Dou, Dandan Xu, Li Feng, Yongze Liu, Ziwen Du, Liqiu Zhang. (2022) Fe0-loaded superfine powdered activated carbon prepared by ball milling for synergistic adsorption and persulfate activation to remove aqueous carbamazepine. CHEMOSPHERE, 293 (133665). [PMID:35051510] [10.1016/j.chemosphere.2022.133665] |
7. Xiangyu Chen, Juanjuan Yao, Hongsen Dong, Mingjian Hong, Naiyun Gao, Zhi Zhang, Wenchao Jiang. (2021) Enhanced bezafibrate degradation and power generation via the simultaneous PMS activation in visible light photocatalytic fuel cell. WATER RESEARCH, 207 (117800). [PMID:34741902] [10.1016/j.watres.2021.117800] |
8. Yang Deng, Ji Ma, Xin Weng, Yuqin Wang, Maoru Li, Tingting Yang, Zhiyang Dou, Zhiqi Yin, Jing Shang. (2021) Kaempferol-3-O-Glucuronide Ameliorates Non-Alcoholic Steatohepatitis in High-Cholesterol-Diet-Induced Larval Zebrafish and HepG2 Cell Models via Regulating Oxidation Stress. Life-Basel, 11 (5): (445). [PMID:34069176] [10.3390/life11050445] |
9. Yang Guo, Erzhuo Zhao, Jun Wang, Xiaoyuan Zhang, Haiou Huang, Gang Yu, Yujue Wang. (2020) Comparison of emerging contaminant abatement by conventional ozonation, catalytic ozonation, O3/H2O2 and electro-peroxone processes. JOURNAL OF HAZARDOUS MATERIALS, 389 (121829). [PMID:31836369] [10.1016/j.jhazmat.2019.121829] |
10. Nadeem Muhammad, Dandan Guo, Yun Zhang, Azeem Intisar, Qamar Subhani, Muhammad Abdul Qadir, Hairong Cui. (2019) Online clean-up setup for the determination of non-fluorescent acidic pharmaceutical drugs in complex biological samples. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1126-1127 (121708). [PMID:31437773] [10.1016/j.jchromb.2019.06.035] |
11. Ji Ma, Hongli Yin, Maoru Li, Yang Deng, Owais Ahmad, Guohong Qin, Qiangqiang He, Jiajing Li, Kai Gao, Junyi Zhu, Bing Wang, Susu Wu, Tao Wang, Jing Shang. (2019) A Comprehensive Study of High Cholesterol Diet-Induced Larval Zebrafish Model: A Short-Time In Vivo Screening Method for Non-Alcoholic Fatty Liver Disease Drugs. International Journal of Biological Sciences, 15 (5): ( 973–983). [PMID:31182918] [10.7150/ijbs.30013] |
12. Shen Chang-shuai, Zhou Cai-rong. (2016) Investigation of the thermal decomposition kinetics of bezafibrate. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 126 (2): (959-967). [PMID:] [10.1007/s10973-016-5565-9] |