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BGJ398 (NVP-BGJ398) - ≥98%, high purity , Fibroblast growth factor receptor inhibitor, CAS No.872511-34-7, Fibroblast growth factor receptor inhibitor

Moligand™
≥98%

CAS#: 872511-34-7
Formula: C₂₆H₃₁Cl₂N₇O₃
Molecular Weight: 560.48
PubChem CID: 53235510

Item Number

N127052

Grouped product items
SKU	Size	Availability	Price
N127052-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$48.90
N127052-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$118.90
N127052-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$187.90

View related series

fibroblast growth factor receptor 1 Inhibitor fibroblast growth factor receptor 2 Inhibitor fibroblast growth factor receptor 3 Inhibitor fibroblast growth factor receptor 4 Inhibitor kinase insert domain receptor Inhibitor

Basic Description

Synonyms	Infigratinib\|NVP-BGJ398\|872511-34-7\|BGJ398\|BGJ-398\|BGJ 398\|3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea\|Infigratinib [INN]\|Infigratinib free base\|UNII-A4055ME1VK\|A4055ME1VK\|Infigratinib [US
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Fibroblast growth factor receptor inhibitor
Product Description	BGJ398 (NVP-BGJ398) is a potent and selective FGFR inhibitor for FGFR1/2/3 with IC50 of 0.9 nM/1.4 nM/1 nM, >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. Phase 2. A potent and selective inhibitor of Flg (FGFR-1), Bek (FGFR-2), FGFR-3 and FGFR-4.

Associated Targets

FGFR1 Tclin Fibroblast growth factor receptor 1 6 Activities

Discover Target: FGFR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR2 Tclin Fibroblast growth factor receptor 2 4 Activities

Discover Target: FGFR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR4 Tclin Fibroblast growth factor receptor 4 3 Activities

Discover Target: FGFR4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR3 Tclin Fibroblast growth factor receptor 3 4 Activities

Discover Target: FGFR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMO Tclin Smoothened homolog 1 Activities

Discover Target: SMO

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDR Tclin Vascular endothelial growth factor receptor 2 1 Activities

Discover Target: KDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-[6-[4-(4-ethylpiperazin-1-yl)anilino]pyrimidin-4-yl]-1-methylurea
INCHI	InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)
InChi Key	QADPYRIHXKWUSV-UHFFFAOYSA-N
Canonical SMILES	CCN1CCN(CC1)C2=CC=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl
Isomeric SMILES	CCN1CCN(CC1)C2=CC=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl
PubChem CID	53235510
Molecular Weight	560.48

PubChem CID

CAS Registry No.

ChEMBL Ligand

RCSB PDB Ligand

Reactome Reaction

R-HSA-2077420, R-HSA-2077424, R-HSA-2023462, R-HSA-2029992

Reactome Drug

R-ALL-2038925

DrugCentral Ligand

5459

Certificates

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2 results found

Lot Number	Certificate Type	Date	Item
H1814159	Certificate of Analysis	Feb 23, 2024	N127052
F1620078	Certificate of Analysis	Oct 18, 2023	N127052

References

1. Guagnano V, Furet P, Spanka C, Bordas V, Le Douget M, Stamm C, Brueggen J, Jensen MR, Schnell C, Schmid H et al.. (2011) Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.. J Med Chem, 54 (20): (7066-83). [PMID:21936542]
2. Komla-Ebri D, Dambroise E, Kramer I, Benoist-Lasselin C, Kaci N, Le Gall C, Martin L, Busca P, Barbault F, Graus-Porta D et al.. (2016) Tyrosine kinase inhibitor NVP-BGJ398 functionally improves FGFR3-related dwarfism in mouse model.. J Clin Invest, 126 (5): (1871-84). [PMID:27064282]
3. Botrus G, Raman P, Oliver T, Bekaii-Saab T. (2021) Infigratinib (BGJ398): an investigational agent for the treatment of FGFR-altered intrahepatic cholangiocarcinoma.. Expert Opin Investig Drugs, 30 (4): (309-316). [PMID:33307867]
4. Lee PC, Hendifar A, Osipov A, Cho M, Li D, Gong J. (2021) Targeting the Fibroblast Growth Factor Receptor (FGFR) in Advanced Cholangiocarcinoma: Clinical Trial Progress and Future Considerations.. Cancers (Basel), 13 (7): (589-97). [PMID:33916849]
5. Javle M, Lowery M, Shroff RT, Weiss KH, Springfeld C, Borad MJ, Ramanathan RK, Goyal L, Sadeghi S, Macarulla T et al.. (2018) Phase II Study of BGJ398 in Patients With FGFR-Altered Advanced Cholangiocarcinoma.. J Clin Oncol, 36 (3): (276-282). [PMID:29182496]

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