BI-3406 - 98%, high purity , CAS No.2230836-55-0, SOS Ras/Rac guanine nucleotide exchange factor 1

Item Number

B414265

• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: BI-3406 (compound I-13) is a potent, selective and orally active inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1) with IC50 of 5 nM. BI-3406 reduces the formation of GTP-loaded KRAS, and inhibits MAPK pathway signaling. BI-3406 exhi
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Mechanism of action: SOS Ras/Rac guanine nucleotide exchange factor 1

Product Description

Information

BI-3406 BI-3406 is a potent, orally active and selective inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1) with IC50 of 6 nM. BI-3406 reduces the formation of GTP-loaded KRAS, and inhibits MAPK pathway signaling with anticancer activities.

Targets

K-ras (Cell-free assay) 5 nM

Cell Research(from reference)

Cell lines：NCI-H358, A-549 cells, MIA PaCa-2 cells, PC-9 cells 

Concentrations：61.7 nM, 185 nM, 556 nM, 1670 nM, 5000 nM 

Incubation Time：24 h, 48 h, 72 h