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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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B420838-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $241.90 |
PDE Inhibitors
Synonyms | Osoresnontrine | BI-409306 | 1189767-28-9 | Osoresnontrine [INN] | BI 409306 | O9OC34WOAY | SUB 166499 | CHEMBL4206492 | 1-(oxan-4-yl)-6-(pyridin-2-ylmethyl)-5H-pyrazolo[3,4-d]pyrimidin-4-one | 6-(Pyridin-2-ylmethyl)-1-(tetrahydro-2H-pyran-4-yl)-1,7-dihydro-4H-pyrazolo[3,4 |
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Specifications & Purity | 10mM in DMSO |
Biochemical and Physiological Mechanisms | BI 409306 (SUB 166499) is a potent and selective inhibitor of human and rat PDE9A with mean IC50 of 65 nM and 168 nM, respectively. Treatment with BI 409306 increases brain cGMP levels, promotes long-term potentiation, and improves episodic and working me |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Product Description | Information BI-409306 BI 409306 (SUB 166499) is a potent and selective inhibitor of human and rat PDE9A with mean IC50 of 65 nM and 168 nM, respectively. Treatment with BI 409306 increases brain cGMP levels, promotes long-term potentiation, and improves episodic and working memory performance in rodents. Targets human PDE9A (Cell-free assay); rat PDE9A (Cell-free assay) 65 nM; 168 nM |
ALogP | 0.421 |
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HBD Count | 1 |
Rotatable Bond | 3 |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 1-(oxan-4-yl)-6-(pyridin-2-ylmethyl)-5H-pyrazolo[3,4-d]pyrimidin-4-one |
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INCHI | InChI=1S/C16H17N5O2/c22-16-13-10-18-21(12-4-7-23-8-5-12)15(13)19-14(20-16)9-11-3-1-2-6-17-11/h1-3,6,10,12H,4-5,7-9H2,(H,19,20,22) |
InChi Key | BZTIJCSHNVZMES-UHFFFAOYSA-N |
Canonical SMILES | C1COCCC1N2C3=C(C=N2)C(=O)NC(=N3)CC4=CC=CC=N4 |
Isomeric SMILES | C1COCCC1N2C3=C(C=N2)C(=O)NC(=N3)CC4=CC=CC=N4 |
PubChem CID | 135908617 |
Molecular Weight | 311.34 |
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DMSO(mg / mL) Max Solubility | 62 |
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DMSO(mM) Max Solubility | 199.13920472795 |
Water(mg / mL) Max Solubility | ˂1 |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed |
Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |