BI-409306 - 10mM in DMSO, high purity , CAS No.1189767-28-9

  • 10mM in DMSO
Item Number
B420838
Grouped product items
SKUSizeAvailabilityPrice Qty
B420838-1ml
1ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$241.90

PDE Inhibitors

Basic Description

SynonymsOsoresnontrine | BI-409306 | 1189767-28-9 | Osoresnontrine [INN] | BI 409306 | O9OC34WOAY | SUB 166499 | CHEMBL4206492 | 1-(oxan-4-yl)-6-(pyridin-2-ylmethyl)-5H-pyrazolo[3,4-d]pyrimidin-4-one | 6-(Pyridin-2-ylmethyl)-1-(tetrahydro-2H-pyran-4-yl)-1,7-dihydro-4H-pyrazolo[3,4
Specifications & Purity10mM in DMSO
Biochemical and Physiological MechanismsBI 409306 (SUB 166499) is a potent and selective inhibitor of human and rat PDE9A with mean IC50 of 65 nM and 168 nM, respectively. Treatment with BI 409306 increases brain cGMP levels, promotes long-term potentiation, and improves episodic and working me
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
Product Description

Information

BI-409306 BI 409306 (SUB 166499) is a potent and selective inhibitor of human and rat PDE9A with mean IC50 of 65 nM and 168 nM, respectively. Treatment with BI 409306 increases brain cGMP levels, promotes long-term potentiation, and improves episodic and working memory performance in rodents.

Targets

human PDE9A (Cell-free assay); rat PDE9A (Cell-free assay) 65 nM; 168 nM

Product Properties

ALogP0.421
HBD Count1
Rotatable Bond3

Associated Targets(Human)

PDE9A Tchem High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 1-(oxan-4-yl)-6-(pyridin-2-ylmethyl)-5H-pyrazolo[3,4-d]pyrimidin-4-one
INCHI InChI=1S/C16H17N5O2/c22-16-13-10-18-21(12-4-7-23-8-5-12)15(13)19-14(20-16)9-11-3-1-2-6-17-11/h1-3,6,10,12H,4-5,7-9H2,(H,19,20,22)
InChi Key BZTIJCSHNVZMES-UHFFFAOYSA-N
Canonical SMILES C1COCCC1N2C3=C(C=N2)C(=O)NC(=N3)CC4=CC=CC=N4
Isomeric SMILES C1COCCC1N2C3=C(C=N2)C(=O)NC(=N3)CC4=CC=CC=N4
PubChem CID 135908617
Molecular Weight 311.34

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

DMSO(mg / mL) Max Solubility62
DMSO(mM) Max Solubility199.13920472795
Water(mg / mL) Max Solubility˂1

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

Precautionary Statements

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

Related Documents

Solution Calculators