BI-D1870 - ≥98%, high purity , CAS No.501437-28-1, Inhibitor of ribosomal protein S6 kinase A1;Inhibitor of ribosomal protein S6 kinase A2;Inhibitor of ribosomal protein S6 kinase A3;Inhibitor of ribosomal protein S6 kinase A6
BI-D1870 - ≥98%, high purity , CAS No.501437-28-1, Inhibitor of ribosomal protein S6 kinase A1;Inhibitor of ribosomal protein S6 kinase A2;Inhibitor of ribosomal protein S6 kinase A3;Inhibitor of ribosomal protein S6 kinase A6
BI-D1870 is a cell permeable, ATP-competitive inhibitor of the four isoforms of ribosomal S6 kinase (p90 RSK) (IC50's at 100μM ATP: RSK1 = 31nM, RSK2 = 24nM, RSK3 = 18nM, RSK4 = 15nM). It does not significantly inhibit 10 other AGC kinases, and over 40 ot
Storage Temp
Protected from light,Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of ribosomal protein S6 kinase A1;Inhibitor of ribosomal protein S6 kinase A2;Inhibitor of ribosomal protein S6 kinase A3;Inhibitor of ribosomal protein S6 kinase A6
Product Description
BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B A cell permeable, ATP-competitive inhibitor.
1.Sapkota GP, Cummings L, Newell FS, Armstrong C, Bain J, Frodin M, Grauert M, Hoffmann M, Schnapp G, Steegmaier M et al.. (2007) BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo.. Biochem J, 401 (1):(29-38). [PMID:17040210]
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C2321417