Selective telomerase inhibitor (IC50values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere shortening in exponentially growing NCI-H460 lung carcinoma cells and
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Note
50mg卖完停产，不再备货
Product Description
BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM. A selective telomerase inhibitor.
3.Lin Liu, Daohong Wu, Shuang Zhen, Kaiqing Lu, Xinyao Yi, Zhifang Sun. (2021) Electrochemical detection of telomerase in cancer cells based on the in-situ formation of streptavidin-biotin-DNA-biotin networks for signal amplification. SENSORS AND ACTUATORS B-CHEMICAL, 334 (129659). [PMID:]
References
1.Shunyu Zhang, Jinxia Li, Liang Yan, Yue You, Feng Zhao, Jixing Cheng, Limin Yang, Yanqi Sun, Qingchao Chang, Ru Liu, Yunhui Li. (2023) Zeolitic Imidazolate Framework-8 (ZIF-8) as a Drug Delivery Vehicle for the Transport and Release of Telomerase Inhibitor BIBR 1532. Nanomaterials, 13 (11):(1779). [PMID:37299682]
3.Lin Liu, Daohong Wu, Shuang Zhen, Kaiqing Lu, Xinyao Yi, Zhifang Sun. (2021) Electrochemical detection of telomerase in cancer cells based on the in-situ formation of streptavidin-biotin-DNA-biotin networks for signal amplification. SENSORS AND ACTUATORS B-CHEMICAL, 334 (129659). [PMID:]
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J1520071