BIBX 1382 - ≥97%, high purity , Epidermal growth factor receptor erbB1 inhibitor, CAS No.196612-93-8, Epidermal growth factor receptor erbB1 inhibitor

Item Number

B337821

• Synonyms: Falnidamol|196612-93-8|BIBX 1382|BIBX1382|BIBX-1382|Falnidamol [INN]|N8-(3-Chloro-4-fluorophenyl)-N2-(1-methylpiperidin-4-yl)pyrimido[5,4-d]pyrimidine-2,8-diamine|CHEMBL258940|0MU316797D|Bibx 1382bs|4-N-(3-chloro-4-fluorophenyl)-6-N-(1-methylpiperidin-4-y
• Specifications & Purity: Moligand™, ≥97%
• Biochemical and Physiological Mechanisms: Cell permeable: yes Target IC50: 3 nM against EGFR (ErbB-1, HER-1) in cell-free enzymatic reactions; 0.15, 1.82, and 3.2 µM in EGF-, HGF-, and FCS-dependent thymidine incorporation, respectively, in KB cells Primary Target EGFR (ErbB-1, HER-1) Product com
• Storage Temp: Protected from light,Store at -20°C,Desiccated
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Epidermal growth factor receptor erbB1 inhibitor

Product Description

Falnidamol (BIBX 1382) is an orally active, selective EGFR tyrosine kinase inhibitor with an IC50 of 3 nM. Falnidamol displays > 1000-fold lower potency against ErbB2 (IC50=3.4 μM) and a range of other related tyrosine kinases (IC50>10 μM). Falnidamol is a pyrimido-pyrimidine compound and has anti-cancer activity.