Bilirubin - 2mM in DMSO, high purity , CAS No.635-65-4(DMSO)

14 Citations
Item Number
B425226
Grouped product items
SKUSizeAvailabilityPrice Qty
B425226-1ml
1ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$167.90

Basic Description

Synonymsbilirubin | 635-65-4 | Hematoidin | Hemetoidin | Bilirubin IX-alpha | Cholerythrin | Bilibubin | Bilirubin IX.alpha. | 3-[2-[[3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxopyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxopyrro
Specifications & PurityMoligand™, 2mM in DMSO
Biochemical and Physiological MechanismsWell over 99% of total bilirubin is transported as a conjugate with albumin. Abnormally high levels of bilirubin can cause severe neurological damage, but mildly elevated levels are linked to protection from oxidative stress.
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
GradeMoligand™
Product Description

Bilirubin is a principal pigment of bile and one of the major end products of hemoglobin decomposition. It contains conjugated double bonds and reactive hydrogen atoms. Serves as a physiological antioxidant. Reported to cross the blood-brain barrier and exert significant antioxidant effects in the brain. This product corresponds to the unconjugated form. Extinction coefficient (454 nm, CHCl3):59,100-62,300 M-1cm-1.
A principal pigment of bile and one of the major end products of hemoglobin decomposition

Associated Targets(Human)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
VDR Tclin Vitamin D receptor (26531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CASP1 Tchem Caspase-1 (6235 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CASP7 Tchem Caspase-7 (3146 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UGT1A4 Tbio UDP-glucuronosyltransferase 1A4 (288 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Caco-2 (12174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UGT2B7 Tchem UDP-glucuronosyltransferase 2B7 (787 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UGT2B17 Tbio UDP-glucuronosyltransferase 2B17 (197 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UGT1A1 Tchem UDP-glucuronosyltransferase 1-1 (448 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1A2 Tchem Solute carrier organic anion transporter family member 1A2 (104 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UGT1A6 Tbio UDP-glucuronosyltransferase 1-6 (221 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UGT1A9 Tbio UDP-glucuronosyltransferase 1-9 (343 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MRGPRX4 Tchem Mas-related G-protein coupled receptor member X4 (415 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Cruzipain (33337 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Salmonella typhimurium (15756 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Impa1 Inositol monophosphatase 1 (16203 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slco1a1 Solute carrier organic anion transporter family member 1A1 (265 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 3-[2-[[3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxopyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxopyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
INCHI InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-
InChi Key BPYKTIZUTYGOLE-IFADSCNNSA-N
Canonical SMILES CC1=C(NC(=C1CCC(=O)O)CC2=C(C(=C(N2)C=C3C(=C(C(=O)N3)C)C=C)C)CCC(=O)O)C=C4C(=C(C(=O)N4)C=C)C
Isomeric SMILES CC1=C(NC(=C1CCC(=O)O)CC2=C(C(=C(N2)/C=C\3/C(=C(C(=O)N3)C)C=C)C)CCC(=O)O)/C=C\4/C(=C(C(=O)N4)C=C)C
WGK Germany 2
RTECS DU3038000
PubChem CID 5280352
Molecular Weight 584.66
Beilstein 74376

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SensitivityLight & Heat sensitive
Refractive Index1.72
Boil Point(°C)925.16°C/760mmHg
Melt Point(°C)192°C

Safety and Hazards(GHS)

Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

WGK Germany 2
RTECS DU3038000
Merck Index 1218

Related Documents

FAQs and Articles

Citations of This Product

1. Wan Zhou, Wenbin Hu, Qiancheng Zhan, Minjun Zhang, Xinjie Liu, Wajid Hussain, Huibin Yu, Shenqi Wang, Lei Zhou.  (2023)  Novel hemoperfusion adsorbents based on collagen for efficient bilirubin removal – A thought from yellow skin of patients with hyperbilirubinemia.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  253  (7): (127321).  [PMID:37820900]
2. Huimin Zhou, Anni Zhu, Caiyin Wang, Xiaoyu Guo, Ye Ying, Yiping Wu, Xinling Liu, Feng Wang, Ying Wen, Haifeng Yang.  (2024)  Preparation of gold nanoparticles loaded MOF-199 for SERS detection of 5-hydroxyindole-3-acetic acid in serum.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  304  (123280).  [PMID:37619474]
3. Jingyu Xiao, Yanxia Chen, Tailin Xu, Xueji Zhang.  (2024)  Hand-held Raman spectrometer-based flexible plasmonic biosensor for label-free multiplex urinalysis.  TALANTA,  266  (124966).  [PMID:37499361]
4. Ying Xu, Chenguang Hu, Jiayu liu, Haoran Guo, Jingkai Gao, Chi Wang, Chengbin Wang.  (2023)  Detection of synovial fluid LTF and S100A8 by chemiluminescence immunoassay for the diagnosis of periprosthetic joint infection.  CLINICA CHIMICA ACTA,  545  (117369).  [PMID:37127230]
5. Shuai Liu, Keming Zheng, Yilin Jiang, Susu Gai, Bohan Li, Dehai Li, Shuang Yang, Zhihua Lv.  (2023)  Biotransformation of Penindolone, an Influenza A Virus Inhibitor.  MOLECULES,  28  (3): (1479).  [PMID:36771146]
6. Weimin Kong, Xueying Sun, Siyu Yu, Peihua Liu, Xiaoke Zheng, Jiaxin Zhang, Liang Zhu, Tianxin Jiang, Mengmeng Jin, Jinghui Gao, Xiaomin Fan, Xiaodong Liu, Li Liu.  (2023)  Bile duct ligation increased dopamine levels in the cerebral cortex of rats partly due to induction of tyrosine hydroxylase.  BRITISH JOURNAL OF PHARMACOLOGY,  180  (13): (1690-1709).  [PMID:36692417]
7. Liu Muhua, Zhang Wen, Zhang Panpan, Yuan Ling, Li Hao, Zhan Jinjie, Zhao Wenjun, Mei Xi.  (2023)  Enhanced Hemocompatibility of Lysine Grafted Polyacrylonitrile Electrospun Nanofiber Membranes as a Potential Bilirubin Adsorption in Hemoperfusion.  JOURNAL OF POLYMERS AND THE ENVIRONMENT,  31  (4): (1553-1567).  [PMID:]
8. Ping Li, Yiting Yang, Zijin Lin, Shijin Hong, Ling Jiang, Han Zhou, Lu Yang, Liang Zhu, Xiaodong Liu, Li Liu.  (2022)  Bile Duct Ligation Impairs Function and Expression of Mrp1 at Rat Blood–Retinal Barrier via Bilirubin-Induced P38 MAPK Pathway Activations.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  23  (14): (7666).  [PMID:35887010]
9. Yilin Wang, Shanshan Wang, Xueqin He, Yupei Li, Tao Xu, Lin Xu, Bo Yang, Xinnian Fan, Weifeng Zhao, Changsheng Zhao.  (2023)  A breakthrough trial of an artificial liver without systemic heparinization in hyperbilirubinemia beagle models.  Bioactive Materials,  20  (651).  [PMID:35846839]
10. Yaotian Peng, Xiaoyan Feng, Jianming Jiang, Li Ren.  (2022)  Controllable polyvinylpyrrolidone modified Polystyrene divinylbenzene for efficient adsorption of bilirubin and improvement of hemocompatibility.  EUROPEAN POLYMER JOURNAL,  170  (111172).  [PMID:]
11. Mei Jianfeng, Wu Xia, Zheng Sujing, Yi Yu, Wang Xudong, Ying Guoqing.  (2022)  Production of bilirubin by biotransformation of biliverdin using recombinant Escherichia coli cells.  BIOPROCESS AND BIOSYSTEMS ENGINEERING,  45  (3): (563-571).  [PMID:35066674]
12. Kangle Yang, Yaotian Peng, Lin Wang, Li Ren.  (2021)  Polymyxin B engineered polystyrene-divinylbenzene microspheres for the adsorption of bilirubin and endotoxin.  RSC Advances,  11  (63): (39978-39984).  [PMID:35494100]
13. Chengli Zhang, Xun You, Yuliang Li, Yuanyuan Zuo, Wei Wang, DanDan Li, ShengWei Huang, Hangzhi Hu, Feng Yuan, Fuqiang Shao, Minggang Yin.  (2022)  A novel electrochemical aptasensor for serum dopamine detection based on methylene blue-integrated m-PdNFs signal material.  SENSORS AND ACTUATORS B-CHEMICAL,  354  (131233).  [PMID:]
14. Jie Zhou, Xueliang Wang, Jiajie Chen, Youjun Zeng, Dayong Gu, Bruce Zhi Gao, Yonghong Shao.  (2022)  Polymeric microsphere enhanced surface plasmon resonance imaging immunosensor for occult blood monitoring.  SENSORS AND ACTUATORS B-CHEMICAL,  350  (130858).  [PMID:]

References

1. Wan Zhou, Wenbin Hu, Qiancheng Zhan, Minjun Zhang, Xinjie Liu, Wajid Hussain, Huibin Yu, Shenqi Wang, Lei Zhou.  (2023)  Novel hemoperfusion adsorbents based on collagen for efficient bilirubin removal – A thought from yellow skin of patients with hyperbilirubinemia.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  253  (7): (127321).  [PMID:37820900]
2. Huimin Zhou, Anni Zhu, Caiyin Wang, Xiaoyu Guo, Ye Ying, Yiping Wu, Xinling Liu, Feng Wang, Ying Wen, Haifeng Yang.  (2024)  Preparation of gold nanoparticles loaded MOF-199 for SERS detection of 5-hydroxyindole-3-acetic acid in serum.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  304  (123280).  [PMID:37619474]
3. Jingyu Xiao, Yanxia Chen, Tailin Xu, Xueji Zhang.  (2024)  Hand-held Raman spectrometer-based flexible plasmonic biosensor for label-free multiplex urinalysis.  TALANTA,  266  (124966).  [PMID:37499361]
4. Ying Xu, Chenguang Hu, Jiayu liu, Haoran Guo, Jingkai Gao, Chi Wang, Chengbin Wang.  (2023)  Detection of synovial fluid LTF and S100A8 by chemiluminescence immunoassay for the diagnosis of periprosthetic joint infection.  CLINICA CHIMICA ACTA,  545  (117369).  [PMID:37127230]
5. Shuai Liu, Keming Zheng, Yilin Jiang, Susu Gai, Bohan Li, Dehai Li, Shuang Yang, Zhihua Lv.  (2023)  Biotransformation of Penindolone, an Influenza A Virus Inhibitor.  MOLECULES,  28  (3): (1479).  [PMID:36771146]
6. Weimin Kong, Xueying Sun, Siyu Yu, Peihua Liu, Xiaoke Zheng, Jiaxin Zhang, Liang Zhu, Tianxin Jiang, Mengmeng Jin, Jinghui Gao, Xiaomin Fan, Xiaodong Liu, Li Liu.  (2023)  Bile duct ligation increased dopamine levels in the cerebral cortex of rats partly due to induction of tyrosine hydroxylase.  BRITISH JOURNAL OF PHARMACOLOGY,  180  (13): (1690-1709).  [PMID:36692417]
7. Liu Muhua, Zhang Wen, Zhang Panpan, Yuan Ling, Li Hao, Zhan Jinjie, Zhao Wenjun, Mei Xi.  (2023)  Enhanced Hemocompatibility of Lysine Grafted Polyacrylonitrile Electrospun Nanofiber Membranes as a Potential Bilirubin Adsorption in Hemoperfusion.  JOURNAL OF POLYMERS AND THE ENVIRONMENT,  31  (4): (1553-1567).  [PMID:]
8. Ping Li, Yiting Yang, Zijin Lin, Shijin Hong, Ling Jiang, Han Zhou, Lu Yang, Liang Zhu, Xiaodong Liu, Li Liu.  (2022)  Bile Duct Ligation Impairs Function and Expression of Mrp1 at Rat Blood–Retinal Barrier via Bilirubin-Induced P38 MAPK Pathway Activations.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  23  (14): (7666).  [PMID:35887010]
9. Yilin Wang, Shanshan Wang, Xueqin He, Yupei Li, Tao Xu, Lin Xu, Bo Yang, Xinnian Fan, Weifeng Zhao, Changsheng Zhao.  (2023)  A breakthrough trial of an artificial liver without systemic heparinization in hyperbilirubinemia beagle models.  Bioactive Materials,  20  (651).  [PMID:35846839]
10. Yaotian Peng, Xiaoyan Feng, Jianming Jiang, Li Ren.  (2022)  Controllable polyvinylpyrrolidone modified Polystyrene divinylbenzene for efficient adsorption of bilirubin and improvement of hemocompatibility.  EUROPEAN POLYMER JOURNAL,  170  (111172).  [PMID:]
11. Mei Jianfeng, Wu Xia, Zheng Sujing, Yi Yu, Wang Xudong, Ying Guoqing.  (2022)  Production of bilirubin by biotransformation of biliverdin using recombinant Escherichia coli cells.  BIOPROCESS AND BIOSYSTEMS ENGINEERING,  45  (3): (563-571).  [PMID:35066674]
12. Kangle Yang, Yaotian Peng, Lin Wang, Li Ren.  (2021)  Polymyxin B engineered polystyrene-divinylbenzene microspheres for the adsorption of bilirubin and endotoxin.  RSC Advances,  11  (63): (39978-39984).  [PMID:35494100]
13. Chengli Zhang, Xun You, Yuliang Li, Yuanyuan Zuo, Wei Wang, DanDan Li, ShengWei Huang, Hangzhi Hu, Feng Yuan, Fuqiang Shao, Minggang Yin.  (2022)  A novel electrochemical aptasensor for serum dopamine detection based on methylene blue-integrated m-PdNFs signal material.  SENSORS AND ACTUATORS B-CHEMICAL,  354  (131233).  [PMID:]
14. Jie Zhou, Xueliang Wang, Jiajie Chen, Youjun Zeng, Dayong Gu, Bruce Zhi Gao, Yonghong Shao.  (2022)  Polymeric microsphere enhanced surface plasmon resonance imaging immunosensor for occult blood monitoring.  SENSORS AND ACTUATORS B-CHEMICAL,  350  (130858).  [PMID:]

Solution Calculators