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Bindarit - ≥98%, high purity , CAS No.130641-38-2, Inhibitor of fatty acid binding protein 4

Moligand™
≥98%

CAS#: 130641-38-2
Formula: C₁₉H₂₀N₂O₃
Molecular Weight: 324.37
PubChem CID: 71354

Item Number

B129927

Grouped product items
SKU	Size	Availability	Price
B129927-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$142.90
B129927-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$236.90
B129927-50mg	50mg	In stock	$593.90

CCL2, CCL7 and CCL8 inhibitor. Anti-inflammatory agent.

View related series

fatty acid binding protein 4 Inhibitor

Basic Description

Synonyms	Bindarit\|130641-38-2\|2-((1-Benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid\|AF2838\|2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid\|AF 2838\|AF-2838\|2-[(1-benzyl-1h-indazol-3-yl)methoxy]-2-methylpropanoic acid\|Propanoic acid, 2-methyl-2-[[1-(
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Bindarit(AF-2838), a CCL2, CCL7 and CCL8 inhibitor, is an anti-inflammatory agent.CCL2, CCL7 and CCL8 inhibitor. Anti-inflammatory agent. Shows antiproliferative, antimetastatic and antitumor effects in vivo. Prevents neuroinflammation in vivo . Orally ac
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of fatty acid binding protein 4
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FABP4 Tchem Fatty acid-binding protein, adipocyte 0 Activities

Discover Target: FABP4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC16A3 Tchem Monocarboxylate transporter 4 0 Activities

Discover Target: SLC16A3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid
INCHI	InChI=1S/C19H20N2O3/c1-19(2,18(22)23)24-13-16-15-10-6-7-11-17(15)21(20-16)12-14-8-4-3-5-9-14/h3-11H,12-13H2,1-2H3,(H,22,23)
InChi Key	MTHORRSSURHQPZ-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C(=O)O)OCC1=NN(C2=CC=CC=C21)CC3=CC=CC=C3
Isomeric SMILES	CC(C)(C(=O)O)OCC1=NN(C2=CC=CC=C21)CC3=CC=CC=C3
PubChem CID	71354
Molecular Weight	324.37

PubChem CID

CAS Registry No.

ChEMBL Ligand

DrugBank Ligand

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4 results found

Lot Number	Certificate Type	Date	Item
B2211287	Certificate of Analysis	Nov 17, 2023	B129927
B2211291	Certificate of Analysis	Nov 17, 2023	B129927
I1516056	Certificate of Analysis	Mar 16, 2023	B129927
B2211308	Certificate of Analysis	Feb 16, 2022	B129927

References

1. Shen Z, Kuang S, Zhang M, Huang X, Chen J, Guan M, Qin W, Xu HHK, Lin Z. (2020) Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties.. Cell Mol Immunol, 129 (3): (589-97). [PMID:32678310]
2. Oddi S, Scipioni L, Totaro A, Angelucci C, Dufrusine B, Sabatucci A, Tortolani D, Coletta I, Alisi MA, Polenzani L et al.. (2019) The anti-inflammatory agent bindarit acts as a modulator of fatty acid-binding protein 4 in human monocytic cells.. Sci Rep, 9 (1): (15155). [PMID:31641194]
3. Shen T et al.. (2015) 15-Lipoxygenase and 15-hydroxyeicosatetraenoic acid regulate intravascular thrombosis in pulmonary hypertension.. Am J Physiol Lung Cell Mol Physiol, 309 (5): (L449-62). [PMID:26092993]
4. Kripnerová M et al.. (2021) Complex Interplay of Genes Underlies Invasiveness in Fibrosarcoma Progression Model.. J Clin Med, 10 (11): [PMID:34070472]

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