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Bindarit - ≥98%, high purity , CAS No.130641-38-2, Inhibitor of fatty acid binding protein 4

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Bindarit - ≥98%, high purity , CAS No.130641-38-2, Inhibitor of fatty acid binding protein 4

1 Citations

Moligand™

≥98%

CAS#: 130641-38-2
Formula: C₁₉H₂₀N₂O₃
Molecular Weight: 324.37
PubChem CID: 71354

Item Number

B129927

Grouped product items
SKU	Size	Availability	Price
B129927-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$142.90
B129927-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$236.90
B129927-50mg	50mg	In stock	$593.90

CCL2, CCL7 and CCL8 inhibitor. Anti-inflammatory agent.

View related series

fatty acid binding protein 4 Inhibitor

Basic Description

Synonyms	2-[1(1-benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid \| AS-72769 \| D03116 \| SB16551 \| 4-Hydroxymethylbutazolidine hemisuccinate \| AB01566103_02 \| Q27281631 \| AF2838 \| AF-2838 \| HY-B0498 \| BCP22728 \| SW219174-1 \| AF 2838 \| Bindarit (USAN/INN) \| HMS
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Bindarit(AF-2838), a CCL2, CCL7 and CCL8 inhibitor, is an anti-inflammatory agent.CCL2, CCL7 and CCL8 inhibitor. Anti-inflammatory agent. Shows antiproliferative, antimetastatic and antitumor effects in vivo. Prevents neuroinflammation in vivo . Orally ac
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of fatty acid binding protein 4
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.

Associated Targets(Human)

FABP4 Tchem Fatty acid-binding protein, adipocyte (0 Activities)

Discover Target: FABP4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC16A3 Tchem Monocarboxylate transporter 4 (196 Activities)

Discover Target: SLC16A3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Discover Target:

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid
INCHI	InChI=1S/C19H20N2O3/c1-19(2,18(22)23)24-13-16-15-10-6-7-11-17(15)21(20-16)12-14-8-4-3-5-9-14/h3-11H,12-13H2,1-2H3,(H,22,23)
InChi Key	MTHORRSSURHQPZ-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C(=O)O)OCC1=NN(C2=CC=CC=C21)CC3=CC=CC=C3
Isomeric SMILES	CC(C)(C(=O)O)OCC1=NN(C2=CC=CC=C21)CC3=CC=CC=C3
PubChem CID	71354
Molecular Weight	324.37

Database links

PubChem CID	71354
CAS Registry No.	130641-38-2
ChEMBL Ligand	CHEMBL2107549
DrugBank Ligand	DB12739

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
B2211287	Certificate of Analysis	Nov 17, 2023	B129927
B2211291	Certificate of Analysis	Nov 17, 2023	B129927
I1516056	Certificate of Analysis	Mar 16, 2023	B129927
B2211308	Certificate of Analysis	Feb 16, 2022	B129927

Chemical and Physical Properties

Solubility	DMSO 65 mg/mL Water <1 mg/mL Ethanol 65 mg/mL

Citations of This Product

1. Chan-juan Chai, Yao Sun, Rui-fang Chi, Hui-yu Yang, Bin Yang, Bao Li. (2024) Astragaloside IV alleviates LPS-induced cardiomyocyte hypertrophy and collagen expression associated with CCL2-mediated activation of NF-κB signaling pathway. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 693 (149367). [PMID:38091841]

References

1. Shen Z, Kuang S, Zhang M, Huang X, Chen J, Guan M, Qin W, Xu HHK, Lin Z. (2020) Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties.. Cell Mol Immunol, 129 (3): (589-97). [PMID:32678310]
2. Oddi S, Scipioni L, Totaro A, Angelucci C, Dufrusine B, Sabatucci A, Tortolani D, Coletta I, Alisi MA, Polenzani L et al.. (2019) The anti-inflammatory agent bindarit acts as a modulator of fatty acid-binding protein 4 in human monocytic cells.. Sci Rep, 9 (1): (15155). [PMID:31641194]
3. Shen T et al.. (2015) 15-Lipoxygenase and 15-hydroxyeicosatetraenoic acid regulate intravascular thrombosis in pulmonary hypertension.. Am J Physiol Lung Cell Mol Physiol, 309 (5): (L449-62). [PMID:26092993]
4. Kripnerová M et al.. (2021) Complex Interplay of Genes Underlies Invasiveness in Fibrosarcoma Progression Model.. J Clin Med, 10 (11): [PMID:34070472]
5. Chan-juan Chai, Yao Sun, Rui-fang Chi, Hui-yu Yang, Bin Yang, Bao Li. (2024) Astragaloside IV alleviates LPS-induced cardiomyocyte hypertrophy and collagen expression associated with CCL2-mediated activation of NF-κB signaling pathway. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 693 (149367). [PMID:38091841]

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