Basic Description

Synonyms	Binucleine 2 \| 220088-42-6 \| N'-[2-(3-chloro-4-fluorophenyl)-4-cyanopyrazol-3-yl]-N,N-dimethylmethanimidamide \| HMS546I06 \| Probes1_000319 \| Probes2_000073 \| CHEMBL1598812 \| DTXSID90430554 \| Binucleine 2, >=97% (HPLC) \| CCG-41865 \| AKOS040755467 \| N'-(1-(3-Chloro-4-fluoropheny
Specifications & Purity	≥97%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Product Description	Binucleine 2 is a cell-permeable pyrazolo compound that inhibits cytokinesis function of the ARK-2 pathway. It inhibits Histone H3 phosphorylation on Ser\|10\|in mitotic Drosophila Kc167 cells at 20 μM, while inactive in mammalian systems. Binucleine 2 does neither function as a general kinase inhibitor nor inhibit Cdk-dependent entry into mitosis.

Product Properties

pKa	pKa: 4.81

RUNX1 Tbio Runt-related transcription factor 1/Core-binding factor subunit beta (7867 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IUPAC Name	N'-[2-(3-chloro-4-fluorophenyl)-4-cyanopyrazol-3-yl]-N,N-dimethylmethanimidamide
INCHI	InChI=1S/C13H11ClFN5/c1-19(2)8-17-13-9(6-16)7-18-20(13)10-3-4-12(15)11(14)5-10/h3-5,7-8H,1-2H3/b17-8+
InChi Key	MNCYLHJHZOUDLB-CAOOACKPSA-N
Canonical SMILES	CN(C)C=NC1=C(C=NN1C2=CC(=C(C=C2)F)Cl)C#N
Isomeric SMILES	CN(C)/C=N/C1=C(C=NN1C2=CC(=C(C=C2)F)Cl)C#N
WGK Germany	3
PubChem CID	9583179
Molecular Weight	291.71

Enter Lot Number to search for COA:

Solubility	Soluble in DMSO (5 mg/ml), and methanol. Insoluble in water.
Refractive Index	n20D1.61 (Predicted)
Boil Point(°C)	456.96° C at 760 mmHg (Predicted)
Melt Point(°C)	157.45° C (Predicted)

Pictogram(s)	GHS06, GHS05
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H318:Causes serious eye damage
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help.
WGK Germany	3
RIDADR	UN28116.1/PGIII

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.