BIO 1211, CAS No.187735-94-0, Inhibitor of integrin α4β1

Features and benefits
    Item Number
    B288747
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    B288747-1mg
    1mg
    In stock
    $99.90
    B288747-5mg
    5mg
    Available within 4-8 weeks(?)
    Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
    $621.90
    B288747-10mg
    10mg
    Available within 4-8 weeks(?)
    Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
    $1,117.90
    B288747-25mg
    25mg
    Available within 4-8 weeks(?)
    Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
    $2,515.90
    B288747-50mg
    50mg
    Available within 4-8 weeks(?)
    Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
    $4,527.90
    B288747-100mg
    100mg
    Available within 4-8 weeks(?)
    Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
    $8,148.90

    Selective α4β1(VLA-4) inhibitor

    Basic Description

    Product NameBIO 1211, CAS No.187735-94-0
    SynonymsAKOS024457866 | SCHEMBL1223367 | BDBM50074661 | MS-31193 | Q27075284 | (S)-1-{(S)-2-[3-Carboxy-2-((1S,5S)-4-methyl-2-{2-[4-(3-o-tolyl-ureido)-phenyl]-acetylamino}-pentanoylamino)-propionylamino]-3-methyl-butyryl}-pyrrolidine-2-carboxylic acid | L-PROLINE,
    GradeMoligand™
    Specifications & PurityMoligand™, ≥98%
    Biochemical and Physiological MechanismsSelective, high affinityα4β1(Very Late Antigen 4; VLA-4) inhibitor; displays 200-fold selectivity for the activated form ofα4β1(KD= 70 pM; IC50= 0.004μM). Selective forα4β1over a range of other integrins (IC50>100μM forα1β1,α5β1andα6β1).
    SequenceMPUPA-LDVP
    Action TypeINHIBITOR
    Mechanism of actionInhibitor of integrin α4β1

    Associated Targets(Human)

    ITGA4 Tclin Integrin alpha-4 (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    ITGB1 Tclin Integrin beta-1 (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    HT-29 (80576 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    K562 (73714 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    MCF7 (126967 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    HEL (6614 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    Jurkat (10389 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    ITGB3 Tclin Integrin alpha-V/beta-3 (2708 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    ITGB1 Tclin Integrin alpha-4/beta-1 (2269 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    ITGB3 Tclin Integrin alpha-IIb/beta-3 (3481 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    ITGA4 Tclin Integrin alpha-4/beta-7 (610 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    ITGB1 Tclin Integrin alpha-5/beta-1 (686 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    ITGAL Tclin Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 (760 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    ITGAV Tchem Integrin alpha-V/beta-5 (589 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    ITGAV Tchem Integrin alpha-V/beta-6 (509 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    ITGAL Tclin Integrin alpha-L/beta-2 (LFA-1) (51 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Associated Targets(non-human)

    Serum (58 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Mechanisms of Action

    Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

    Product Specifications

    Storage TempStore at -20°C
    Shipped InIce chest + Ice pads
    CAS187735-94-0

    Certificates

    Certificate of Analysis(COA)

    Enter Lot Number to search for COA:

    Find and download the COA for your product by matching the lot number on the packaging.

    7 results found

    Lot NumberCertificate TypeDateItem
    K2315416Certificate of AnalysisOct 27, 2023 B288747
    K2315434Certificate of AnalysisOct 27, 2023 B288747
    K2315439Certificate of AnalysisOct 27, 2023 B288747
    K2315440Certificate of AnalysisOct 27, 2023 B288747
    K2315445Certificate of AnalysisOct 27, 2023 B288747
    K2315446Certificate of AnalysisOct 27, 2023 B288747
    K2315447Certificate of AnalysisOct 27, 2023 B288747

    Genetic information

    Alternate NamesAKOS024457866 | SCHEMBL1223367 | BDBM50074661 | MS-31193 | Q27075284 | (S)-1-{(S)-2-[3-Carboxy-2-((1S,5S)-4-methyl-2-{2-[4-(3-o-tolyl-ureido)-phenyl]-acetylamino}-pentanoylamino)-propionylamino]-3-methyl-butyryl}-pyrrolidine-2-carboxylic acid | L-PROLINE,
    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

    Related Documents

    Solution Calculators