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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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B287562-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $246.90 | |
B287562-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $939.90 |
Potent negative allosteric modulator of LFA-1
Synonyms | (5R)-5-[(4-Bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Potent negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) (Kd= 26 nM). Binds to the I-domain of LFA-1. Reversibly inhibits LFA-1 mediated binding of SKW3 leukemia cells to ICAM-1. Inhibits superantigen (SEB)-induced IL-2 pro |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of integrin; alpha L subunit (antigen CD11A (p180); lymphocyte function-associated antigen 1; alpha polypeptide) |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | (5R)-5-[(4-bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethylimidazolidine-2,4-dione |
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INCHI | InChI=1S/C18H15BrCl2N2O2/c1-18(10-11-3-5-12(19)6-4-11)16(24)23(17(25)22(18)2)15-8-13(20)7-14(21)9-15/h3-9H,10H2,1-2H3/t18-/m1/s1 |
InChi Key | FJNJHZQMQRVZEE-GOSISDBHSA-N |
Canonical SMILES | CC1(C(=O)N(C(=O)N1C)C2=CC(=CC(=C2)Cl)Cl)CC3=CC=C(C=C3)Br |
Isomeric SMILES | C[C@]1(C(=O)N(C(=O)N1C)C2=CC(=CC(=C2)Cl)Cl)CC3=CC=C(C=C3)Br |
PubChem CID | 9803375 |
MeSH Entry Terms | (R)-5-(4-bromophenyl)-3-(3,5-dichlorophenyl)-1,5-dimethyl-imidazolidine-2,4-dione;BIRT 377 |
Molecular Weight | 442.13 |
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Solubility | Solvent:DMSO, Max Conc. mg/mL: 44.21, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 22.11, Max Conc. mM: 50 |
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1. Kelly TA, Jeanfavre DD, McNeil DW, Woska Jr JR, Reilly PL, Mainolfi EA, Kishimoto KM, Nabozny GH, Zinter R, Bormann BJ et al.. (1999) Cutting edge: a small molecule antagonist of LFA-1-mediated cell adhesion.. J Immunol, 163 (10): (5173-7). [PMID:10553036] |