Bisindolylmaleimide VIII acetate - 93%, high purity , CAS No.138516-31-1

Item Number

B274850

• Synonyms: bisindolylmaleimide viii | 138516-31-1 | Ro 31-7549 acetate | Bisindolylmaleimide VIII (acetate) | Ro 31-7549;Bis VIII | acetic acid;3-[1-(3-aminopropyl)indol-3-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione | 1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-
• Specifications & Purity: ≥93%
• Biochemical and Physiological Mechanisms: Potent, selective protein kinase C (PKC) inhibitor (IC 50 = 158 nM for rat brain PKC). Facilitates Fas-mediated apoptosis through a protein kinase C-independent mechanism and inhibits T cell-mediated autoimmune diseases.
• Storage Temp: Store at -20°C,Desiccated
• Shipped In: Ice chest + Ice pads
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

 Product Description：

Bisindolylmaleimide VIII acetate is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC. Bisindolylmaleimide VIII acetate has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively. Bisindolylmaleimide VIII acetate facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases.