Bisphenol A Diglycidyl Ether - ≥85.0%(GC), high purity , CAS No.1675-54-3

  • ≥85%(GC)
Item Number
B131786
Grouped product items
SKUSizeAvailabilityPrice Qty
B131786-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$22.90
B131786-100g
100g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$37.90
B131786-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$67.90

Selective PPARγ antagonist

Basic Description

SynonymsBADGE | 4,4'-Isopropylidenebis[1-(2,3-epoxypropoxy)benzene] | BISPHENOL A DIGLYCIDYL ETHER RESIN | BSPBio_001468 | 2,2-bis(4-(2,3-epoxypropoxy)phenyl)propane | 2,2-bis(4-(2,3-epoxypropoxy)phenyl)-propane | Bio1_001356 | 2,2-Bis(p-hydroxyphenyl)propane dig
Specifications & Purity≥85%
Biochemical and Physiological MechanismsSelective PPARγ antagonist. Induces PPARγ-independent apoptosis of tumor cells. Increases osteoblastogenesis and bone mass in vivo.
Storage TempStore at 2-8°C,Argon charged
Shipped InWet ice
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Bisphenol A Diglycidyl Ether is a diglycidyl ether (BADGE) can inhibit the peroxisome proliferator-activated receptor (PPARγ) and adipocyte differentiation, and has been shown to induce apoptosis in tumor cells. Research shows that BADGE can suppress the tumor necrosis factor-α (TNF-α) and that it has the ability to induce F-actin depolymerization.
An inhibitor of PPARγ and suppressor of TNFα.

Associated Targets(Human)

ESR1 Tclin Estrogen receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NR3C1 Tclin Glucocorticoid receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
RUNX1 Tbio Runt-related transcription factor 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
RORC Tchem Nuclear receptor ROR-gamma (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
VDR Tclin Vitamin D3 receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FTL Tbio Ferritin light chain (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HIF1A Tchem Hypoxia-inducible factor 1-alpha (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
RXRA Tclin Retinoic acid receptor RXR-alpha (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TSHR Tclin Thyrotropin receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NR1H4 Tclin Bile acid receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ALDH1A1 Tchem Retinal dehydrogenase 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
THRB Tclin Thyroid hormone receptor beta (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MAPT Tclin Microtubule-associated protein tau (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TP53 Tchem Cellular tumor antigen p53 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PPARD Tchem Peroxisome proliferator-activated receptor delta (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PPARG Tclin Peroxisome proliferator-activated receptor gamma (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
VDR Tclin Vitamin D receptor (26531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RXRA Tclin Retinoid X receptor alpha (3637 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR1H4 Tclin Bile acid receptor FXR (6228 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lymphoblastoid cell (5959 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Ppard Peroxisome proliferator-activated receptor delta (358 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
H4 (48 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 2-[[4-[2-[4-(oxiran-2-ylmethoxy)phenyl]propan-2-yl]phenoxy]methyl]oxirane
INCHI InChI=1S/C21H24O4/c1-21(2,15-3-7-17(8-4-15)22-11-19-13-24-19)16-5-9-18(10-6-16)23-12-20-14-25-20/h3-10,19-20H,11-14H2,1-2H3
InChi Key LCFVJGUPQDGYKZ-UHFFFAOYSA-N
Canonical SMILES CC(C)(C1=CC=C(C=C1)OCC2CO2)C3=CC=C(C=C3)OCC4CO4
Isomeric SMILES CC(C)(C1=CC=C(C=C1)OCC2CO2)C3=CC=C(C=C3)OCC4CO4
RTECS TX3800000
PubChem CID 2286
Molecular Weight 340.42
Reaxy-Rn 299026

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

27 results found

Lot NumberCertificate TypeDateItem
K2418176Certificate of AnalysisSep 29, 2024 B131786
K2418175Certificate of AnalysisSep 29, 2024 B131786
K2418174Certificate of AnalysisSep 29, 2024 B131786
K2418173Certificate of AnalysisSep 29, 2024 B131786
J2414861Certificate of AnalysisSep 28, 2024 B131786
J2414746Certificate of AnalysisSep 28, 2024 B131786
J2414744Certificate of AnalysisSep 28, 2024 B131786
J2414741Certificate of AnalysisSep 28, 2024 B131786
J2414740Certificate of AnalysisSep 28, 2024 B131786
C2414140Certificate of AnalysisFeb 28, 2024 B131786
C2414139Certificate of AnalysisFeb 28, 2024 B131786
H2405029Certificate of AnalysisJun 01, 2023 B131786
F2313801Certificate of AnalysisJun 01, 2023 B131786
F2313785Certificate of AnalysisJun 01, 2023 B131786
F2313782Certificate of AnalysisJun 01, 2023 B131786
F2313781Certificate of AnalysisJun 01, 2023 B131786
D2307491Certificate of AnalysisJan 12, 2023 B131786
D2307490Certificate of AnalysisJan 12, 2023 B131786
D2307489Certificate of AnalysisJan 12, 2023 B131786
L22141011Certificate of AnalysisNov 21, 2022 B131786
L22141012Certificate of AnalysisNov 21, 2022 B131786
L22141014Certificate of AnalysisNov 21, 2022 B131786
L2215044Certificate of AnalysisNov 21, 2022 B131786
D2214005Certificate of AnalysisMar 07, 2022 B131786
D2214004Certificate of AnalysisMar 07, 2022 B131786
D2214003Certificate of AnalysisMar 07, 2022 B131786
D2214002Certificate of AnalysisMar 07, 2022 B131786

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Chemical and Physical Properties

SolubilitySoluble in 100% ethanol, DMSO (100 mM), DMF, chloroform, methanol, and ethanol (50 mM). Insoluble in PBS, pH 7.2, and water.
SensitivityHeat & Moisture Sensitive.
Refractive Index1.57
Boil Point(°C)210 °C/1 mmHg

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H317:May cause an allergic skin reaction

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

RTECS TX3800000
Reaxy-Rn 299026

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36. Jun Xie, Chaoxuan Xiao, Shuai Shao, Qijun Duan, Qing Xie, Fangcheng Lü.  (2021)  Effect of Bismuth Ferrite Nanometer Filler Element Doping on the Surface Insulation Properties of Epoxy Resin Composites.  Nanomaterials,  11  (9): (2200).  [PMID:34578516] [10.3390/nano11092200]
37. Chenhao Ren, Yao Huang, Wenkui Hao, Dawei Zhang, Xiejing Luo, Lingwei Ma, Jinke Wang, Thee Chowwanonthapunya, Chaofang Dong, Xiaogang Li.  (2022)  Multi-action self-healing coatings with simultaneous recovery of corrosion resistance and adhesion strength.  JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,  101  (18).  [PMID:] [10.1016/j.jmst.2021.05.070]
38. Jiaojiao Zhang, Jinfei Wei, Bucheng Li, Xia Zhao, Junping Zhang.  (2021)  Long-term corrosion protection for magnesium alloy by two-layer self-healing superamphiphobic coatings based on shape memory polymers and attapulgite.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  594  (836).  [PMID:33794405] [10.1016/j.jcis.2021.03.005]
39. Li Chang, Ju Benzhi, Zhang Shufen.  (2021)  Construction of a new green vitrimer material: introducing dynamic covalent bond into carboxymethyl cellulose.  CELLULOSE,  28  (5): (2879-2888).  [PMID:] [10.1007/s10570-021-03763-4]
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41. Hujun Wang, Zhihui Zhang, Jing Zheng, Jie Zhao, Yunhong Liang, Xiujuan Li, Luquan Ren.  (2021)  Multifunctional superhydrophobic surface with dynamically controllable micro/nanostructures for droplet manipulation and friction control.  CHEMICAL ENGINEERING JOURNAL,  417  (127944).  [PMID:] [10.1016/j.cej.2020.127944]
42. Xunzheng Su, Zhen Zhou, Jingcheng Liu, Jing Luo, Ren Liu.  (2020)  A recyclable vanillin-based epoxy resin with high-performance that can compete with DGEBA.  EUROPEAN POLYMER JOURNAL,  140  (110053).  [PMID:] [10.1016/j.eurpolymj.2020.110053]
43. Li Zi-Jian, Zhong Jiang, Liu Mao-Chen, Rong Jin-Chuang, Yang Kun, Zhou Ji-Yong, Shen Liang, Gao Fei, He Hai-Feng.  (2020)  Investigation on Self-healing Property of Epoxy Resins Based on Disulfide Dynamic Links.  CHINESE JOURNAL OF POLYMER SCIENCE,  38  (9): (932-940).  [PMID:] [10.1007/s10118-020-2406-x]
44. Xia Zhao, Jinfei Wei, Bucheng Li, Sibei Li, Ning Tian, Lingyun Jing, Junping Zhang.  (2020)  A self-healing superamphiphobic coating for efficient corrosion protection of magnesium alloy.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  575  (140).  [PMID:32361230] [10.1016/j.jcis.2020.04.097]
45. Chuanhui Xu, Zhongjie Zheng, Wenchao Wu, Lihua Fu, Baofeng Lin.  (2019)  Design of healable epoxy composite based on β-hydroxyl esters crosslinked networks by using carboxylated cellulose nanocrystals as crosslinker.  COMPOSITES SCIENCE AND TECHNOLOGY,  181  (107677).  [PMID:] [10.1016/j.compscitech.2019.06.004]
46. Jingjing Zhang, Yu Chen, Wenying Wu, Zhipeng Wang, Yanjie Chu, Xiaohui Chen.  (2019)  Hollow porous dummy molecularly imprinted polymer as a sorbent of solid-phase extraction combined with accelerated solvent extraction for determination of eight bisphenols in plastic products.  MICROCHEMICAL JOURNAL,  145  (1176).  [PMID:] [10.1016/j.microc.2018.12.031]
47. Lingling Wang, Yan Yin, Gang Hou, Jian Kang, Qiuyue Wang.  (2018)  Peroxisome Proliferator-Activated Receptor (PPARγ) Plays a Protective Role in Cigarette Smoking-Induced Inflammation via AMP-Activated Protein Kinase (AMPK) Signaling.  MEDICAL SCIENCE MONITOR,  24  ( 5168–5177).  [PMID:30044769] [10.12659/MSM.909285]
48. Yufeng Li, Cong Jia, Xiao Zhang, Yanghui Jiang, Min Zhang, Panfang Lu, Hongkun Chen.  (2018)  Synthesis and performance of bio-based epoxy coated urea as controlled release fertilizer.  PROGRESS IN ORGANIC COATINGS,  119  (50).  [PMID:] [10.1016/j.porgcoat.2018.02.013]

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44. Xia Zhao, Jinfei Wei, Bucheng Li, Sibei Li, Ning Tian, Lingyun Jing, Junping Zhang.  (2020)  A self-healing superamphiphobic coating for efficient corrosion protection of magnesium alloy.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  575  (140).  [PMID:32361230] [10.1016/j.jcis.2020.04.097]
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47. Lingling Wang, Yan Yin, Gang Hou, Jian Kang, Qiuyue Wang.  (2018)  Peroxisome Proliferator-Activated Receptor (PPARγ) Plays a Protective Role in Cigarette Smoking-Induced Inflammation via AMP-Activated Protein Kinase (AMPK) Signaling.  MEDICAL SCIENCE MONITOR,  24  ( 5168–5177).  [PMID:30044769] [10.12659/MSM.909285]
48. Yufeng Li, Cong Jia, Xiao Zhang, Yanghui Jiang, Min Zhang, Panfang Lu, Hongkun Chen.  (2018)  Synthesis and performance of bio-based epoxy coated urea as controlled release fertilizer.  PROGRESS IN ORGANIC COATINGS,  119  (50).  [PMID:] [10.1016/j.porgcoat.2018.02.013]

Solution Calculators