Bisphenol A Diglycidyl Ether - ≥85.0%(GC), high purity , CAS No.1675-54-3

34 Citations
  • ≥85%(GC)
Item Number
B131786
Grouped product items
SKUSizeAvailabilityPrice Qty
B131786-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$22.90
B131786-100g
100g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$37.90
B131786-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$67.90

Selective PPARγ antagonist

Basic Description

SynonymsBADGE | 4,4'-Isopropylidenebis[1-(2,3-epoxypropoxy)benzene] | BISPHENOL A DIGLYCIDYL ETHER RESIN | BSPBio_001468 | 2,2-bis(4-(2,3-epoxypropoxy)phenyl)propane | 2,2-bis(4-(2,3-epoxypropoxy)phenyl)-propane | Bio1_001356 | 2,2-Bis(p-hydroxyphenyl)propane dig
Specifications & Purity≥85%(GC)
Biochemical and Physiological MechanismsSelective PPARγ antagonist. Induces PPARγ-independent apoptosis of tumor cells. Increases osteoblastogenesis and bone mass in vivo.
Storage TempStore at 2-8°C,Argon charged
Shipped InWet ice
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Bisphenol A Diglycidyl Ether is a diglycidyl ether (BADGE) can inhibit the peroxisome proliferator-activated receptor (PPARγ) and adipocyte differentiation, and has been shown to induce apoptosis in tumor cells. Research shows that BADGE can suppress the tumor necrosis factor-α (TNF-α) and that it has the ability to induce F-actin depolymerization.
An inhibitor of PPARγ and suppressor of TNFα.

Associated Targets(Human)

ESR1 Tclin Estrogen receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NR3C1 Tclin Glucocorticoid receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
RUNX1 Tbio Runt-related transcription factor 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
RORC Tchem Nuclear receptor ROR-gamma (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
VDR Tclin Vitamin D3 receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FTL Tbio Ferritin light chain (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HIF1A Tchem Hypoxia-inducible factor 1-alpha (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
RXRA Tclin Retinoic acid receptor RXR-alpha (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TSHR Tclin Thyrotropin receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NR1H4 Tclin Bile acid receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ALDH1A1 Tchem Retinal dehydrogenase 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
THRB Tclin Thyroid hormone receptor beta (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MAPT Tclin Microtubule-associated protein tau (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TP53 Tchem Cellular tumor antigen p53 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PPARD Tchem Peroxisome proliferator-activated receptor delta (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PPARG Tclin Peroxisome proliferator-activated receptor gamma (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
VDR Tclin Vitamin D receptor (26531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RXRA Tclin Retinoid X receptor alpha (3637 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR1H4 Tclin Bile acid receptor FXR (6228 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lymphoblastoid cell (5959 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RUNX1 Tbio Runt-related transcription factor 1/Core-binding factor subunit beta (7867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Ppard Peroxisome proliferator-activated receptor delta (358 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
H4 (48 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 2-[[4-[2-[4-(oxiran-2-ylmethoxy)phenyl]propan-2-yl]phenoxy]methyl]oxirane
INCHI InChI=1S/C21H24O4/c1-21(2,15-3-7-17(8-4-15)22-11-19-13-24-19)16-5-9-18(10-6-16)23-12-20-14-25-20/h3-10,19-20H,11-14H2,1-2H3
InChi Key LCFVJGUPQDGYKZ-UHFFFAOYSA-N
Canonical SMILES CC(C)(C1=CC=C(C=C1)OCC2CO2)C3=CC=C(C=C3)OCC4CO4
Isomeric SMILES CC(C)(C1=CC=C(C=C1)OCC2CO2)C3=CC=C(C=C3)OCC4CO4
RTECS TX3800000
PubChem CID 2286
Molecular Weight 340.42
Reaxy-Rn 299026

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

18 results found

Lot NumberCertificate TypeDateItem
C2414140Certificate of AnalysisFeb 28, 2024 B131786
C2414139Certificate of AnalysisFeb 28, 2024 B131786
F2313781Certificate of AnalysisJun 01, 2023 B131786
H2405029Certificate of AnalysisJun 01, 2023 B131786
F2313801Certificate of AnalysisJun 01, 2023 B131786
F2313785Certificate of AnalysisJun 01, 2023 B131786
F2313782Certificate of AnalysisJun 01, 2023 B131786
D2307490Certificate of AnalysisJan 12, 2023 B131786
D2307491Certificate of AnalysisJan 12, 2023 B131786
D2307489Certificate of AnalysisJan 12, 2023 B131786
L22141011Certificate of AnalysisNov 21, 2022 B131786
L22141012Certificate of AnalysisNov 21, 2022 B131786
L22141014Certificate of AnalysisNov 21, 2022 B131786
L2215044Certificate of AnalysisNov 21, 2022 B131786
D2214005Certificate of AnalysisMar 07, 2022 B131786
D2214004Certificate of AnalysisMar 07, 2022 B131786
D2214003Certificate of AnalysisMar 07, 2022 B131786
D2214002Certificate of AnalysisMar 07, 2022 B131786

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Chemical and Physical Properties

SolubilitySoluble in 100% ethanol, DMSO (100 mM), DMF, chloroform, methanol, and ethanol (50 mM). Insoluble in PBS, pH 7.2, and water.
SensitivityHeat & Moisture Sensitive.
Refractive Index1.57
Boil Point(°C)210 °C/1 mmHg

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H317:May cause an allergic skin reaction

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

RTECS TX3800000
Reaxy-Rn 299026

Related Documents

Citations of This Product

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2. Qiaolin Tang, Lu Yuan, Ming Kang, Ying Huang, Li Yang, Qiang Yin, Guanjun Chang.  (2023)  A toughening indole-based epoxy film with efficient anti-counterfeiting properties driven by cation–π interaction.  POLYMER INTERNATIONAL,      [PMID:20123964]
3. Ahmed Saud Abdulhameed, Ruihong Wu, Salis Auwal Musa, Hasan M. Agha, Zeid A. ALOthman, Ali H. Jawad, Sameer Algburi.  (2024)  Bisphenol-A-diglycidyl ether modified chitosan/nano-SiO2 via hydrothermal process: A statistical modeling and adsorption mechanism for reactive orange 16 dye removal.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  256  (128267).  [PMID:37992917]
4. Yue Wang, Weimin Tan, Xinliang Luo, Xingxing Rao, Yaxin Wang, Jinke Wang, W. Suphamitmongkol, Thee Chowwanonthapunya, Lingwei Ma, Dawei Zhang.  (2024)  A novel self-healing coating with mechanically-triggered self-reporting properties: Color and fluorescence dual damage indications.  PROGRESS IN ORGANIC COATINGS,  187  (108147).  [PMID:]
5. Yukun Zeng, Erwei Leng, Yuan Xue, Xun Gong, Jingchun Huang, Jiaqiang E.  (2023)  Synergistic effects in the co-pyrolysis of thermoset epoxy resin and biomass on kinetics and product distribution.  POLYMER DEGRADATION AND STABILITY,  218  (8): (110569).  [PMID:10209123]
6. Zicheng Fan, Insub Noh, Changlong Zhuang, Qingqing Liu, Yanbin Wang, Hyung Do Kim, Meng Yue, Hideo Ohkita, Biaobing Wang.  (2023)  A polar polyimide as multifunctional flame retardant for epoxy resin through constructing intimate 3D interpenetrating polymer network.  EUROPEAN POLYMER JOURNAL,  198  (112383).  [PMID:]
7. Hao Guan, Zhiyong Li, Qinlong Xu, Jingjing Meng, Kai Guo.  (2023)  Dual bio-based epoxy resin as green substitute for DGEBA analogue with high performances.  REACTIVE & FUNCTIONAL POLYMERS,  191  (105687).  [PMID:]
8. Feng Li, Weidong Gu, Qiang Gao, Yi Tan, Cheng Li, Christian Sonne, Jianzhang Li, Ki-Hyun Kim.  (2023)  Scalable Underwater Adhesives with High-Strength, Long-Term, and Harsh-Environment Adhesion Enabled by Heterocyclic Chemistry.  ACS Applied Materials & Interfaces,  15  (31): (37925–37935).  [PMID:37493476]
9. Hechen Liu, Zhanglin Sun, Liwei Wei, Yunpeng Liu, Songsong Zhou, Qi Ge, Chang Liu, Xinyang Li.  (2023)  Double-dynamic crosslinked epoxy vitrimer resin prepared using transesterification and dynamic disulfide bonds: High-performance, degradable, self-healing, environment-friendly.  POLYMER TESTING,  126  (108145).  [PMID:]
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References

1. Xinchen Pan, Yunfan Zhang, Ying Zhang, Mingyu Yang, Zhanwei Yang, Yakun Liu, Ping Zhang, Zhiwei Han, Xin Wang, Yongsheng Fu.  (2024)  Monodispersed Nanodiamonds for Enhanced Anticorrosion of Waterborne Epoxy Coatings.  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,  63  (1): (307–317).  [PMID:]
2. Qiaolin Tang, Lu Yuan, Ming Kang, Ying Huang, Li Yang, Qiang Yin, Guanjun Chang.  (2023)  A toughening indole-based epoxy film with efficient anti-counterfeiting properties driven by cation–π interaction.  POLYMER INTERNATIONAL,      [PMID:20123964]
3. Ahmed Saud Abdulhameed, Ruihong Wu, Salis Auwal Musa, Hasan M. Agha, Zeid A. ALOthman, Ali H. Jawad, Sameer Algburi.  (2024)  Bisphenol-A-diglycidyl ether modified chitosan/nano-SiO2 via hydrothermal process: A statistical modeling and adsorption mechanism for reactive orange 16 dye removal.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  256  (128267).  [PMID:37992917]
4. Yue Wang, Weimin Tan, Xinliang Luo, Xingxing Rao, Yaxin Wang, Jinke Wang, W. Suphamitmongkol, Thee Chowwanonthapunya, Lingwei Ma, Dawei Zhang.  (2024)  A novel self-healing coating with mechanically-triggered self-reporting properties: Color and fluorescence dual damage indications.  PROGRESS IN ORGANIC COATINGS,  187  (108147).  [PMID:]
5. Yukun Zeng, Erwei Leng, Yuan Xue, Xun Gong, Jingchun Huang, Jiaqiang E.  (2023)  Synergistic effects in the co-pyrolysis of thermoset epoxy resin and biomass on kinetics and product distribution.  POLYMER DEGRADATION AND STABILITY,  218  (8): (110569).  [PMID:10209123]
6. Zicheng Fan, Insub Noh, Changlong Zhuang, Qingqing Liu, Yanbin Wang, Hyung Do Kim, Meng Yue, Hideo Ohkita, Biaobing Wang.  (2023)  A polar polyimide as multifunctional flame retardant for epoxy resin through constructing intimate 3D interpenetrating polymer network.  EUROPEAN POLYMER JOURNAL,  198  (112383).  [PMID:]
7. Hao Guan, Zhiyong Li, Qinlong Xu, Jingjing Meng, Kai Guo.  (2023)  Dual bio-based epoxy resin as green substitute for DGEBA analogue with high performances.  REACTIVE & FUNCTIONAL POLYMERS,  191  (105687).  [PMID:]
8. Feng Li, Weidong Gu, Qiang Gao, Yi Tan, Cheng Li, Christian Sonne, Jianzhang Li, Ki-Hyun Kim.  (2023)  Scalable Underwater Adhesives with High-Strength, Long-Term, and Harsh-Environment Adhesion Enabled by Heterocyclic Chemistry.  ACS Applied Materials & Interfaces,  15  (31): (37925–37935).  [PMID:37493476]
9. Hechen Liu, Zhanglin Sun, Liwei Wei, Yunpeng Liu, Songsong Zhou, Qi Ge, Chang Liu, Xinyang Li.  (2023)  Double-dynamic crosslinked epoxy vitrimer resin prepared using transesterification and dynamic disulfide bonds: High-performance, degradable, self-healing, environment-friendly.  POLYMER TESTING,  126  (108145).  [PMID:]
10. Jinke Wang, Lingwei Ma, Zhibin Chen, Yue Wang, Chenhao Ren, Tong Liu, Li Ma, Cunguo Lin, Dawei Zhang.  (2023)  Multi-channel preparation and high-throughput screening of coating fillers with optimized corrosion sensing and inhibition properties for smart protective coatings.  CORROSION SCIENCE,  222  (111390).  [PMID:]
11. Xianliang Li, Bin Gong, Jie Zhang, Yuyang Di, Yan Ding, Zhihao Chen, Wenzhong Yang.  (2023)  A photothermal and pH-responsive intelligent PSBG nanofiller for enhancing the barrier and self-healing performance of the SMP coatings.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,  674  (131899).  [PMID:]
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Solution Calculators