blarcamesine , CAS No.195615-83-9, Agonist of sigma non-opioid intracellular receptor 1

Item Number
B608105
Grouped product items
SKUSizeAvailabilityPrice Qty
B608105-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
B608105-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,001.90

Basic Description

SynonymsBlarcamesine | 195615-83-9 | AVex-73 | THD-DP-FM | AE-37 | AE37 | Blarcamesine [USAN] | Anavex-2-73 | 9T210MMZ3F | Tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanemethanamine | 1-(2,2-diphenyloxolan-3-yl)-N,N-dimethylmethanamine | Blarcamesine (USAN) | Tetrahydro-N,N-dimethyl-2,2-d
Specifications & PurityMoligand™
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of sigma non-opioid intracellular receptor 1

Associated Targets(Human)

SIGMAR1 Tclin Sigma non-opioid intracellular receptor 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM4 Tclin Muscarinic acetylcholine receptor M4 (6041 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Sigmar1 Sigma opioid receptor (160 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 1-(2,2-diphenyloxolan-3-yl)-N,N-dimethylmethanamine
INCHI InChI=1S/C19H23NO/c1-20(2)15-18-13-14-21-19(18,16-9-5-3-6-10-16)17-11-7-4-8-12-17/h3-12,18H,13-15H2,1-2H3
InChi Key BOTHKNZTGGXFEQ-UHFFFAOYSA-N
Canonical SMILES CN(C)CC1CCOC1(C2=CC=CC=C2)C3=CC=CC=C3
Isomeric SMILES CN(C)CC1CCOC1(C2=CC=CC=C2)C3=CC=CC=C3
Alternate CAS 195615-83-9
PubChem CID 9882189
MeSH Entry Terms ANAVEX2-73;blarcamesine;tetrahydro-N, N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride

Certificates

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Related Documents

References

1. Villard V, Espallergues J, Keller E, Vamvakides A, Maurice T.  (2011)  Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma 1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative..  J Psychopharmacol,  25  (8): (1101-17).  [PMID:20829307]
2. Lahmy V, Meunier J, Malmström S, Naert G, Givalois L, Kim SH, Villard V, Vamvakides A, Maurice T.  (2013)  Blockade of Tau hyperphosphorylation and Aβ₁₋₄₂ generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ₁ receptor agonist, in a nontransgenic mouse model of Alzheimer's disease..  Neuropsychopharmacology,  38  (9): (1706-23).  [PMID:23493042]
3. Lahmy V, Long R, Morin D, Villard V, Maurice T.  (2014)  Mitochondrial protection by the mixed muscarinic/σ1 ligand ANAVEX2-73, a tetrahydrofuran derivative, in Aβ25-35 peptide-injected mice, a nontransgenic Alzheimer's disease model..  Front Cell Neurosci,  (3): (463).  [PMID:25653589]
4. Maurice T.  (2016)  Protection by sigma-1 receptor agonists is synergic with donepezil, but not with memantine, in a mouse model of amyloid-induced memory impairments..  Behav Brain Res,  296  (3): (270-278).  [PMID:26386305]
5. Kaufmann WE, Sprouse J, Rebowe N, Hanania T, Klamer D, Missling CU.  (2019)  ANAVEX®2-73 (blarcamesine), a Sigma-1 receptor agonist, ameliorates neurologic impairments in a mouse model of Rett syndrome..  Pharmacol Biochem Behav,  187  (3): (172796).  [PMID:31704481]

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