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(-)-Blebbistatin - ≥98%, high purity , CAS No.856925-71-8

≥98%

CAS#: 856925-71-8
Formula: C₁₈H₁₆N₂O₂
Molecular Weight: 292.33
MDL number: MFCD08460907
PubChem CID: 5287792

Item Number

B129580

Grouped product items
SKU	Size	Availability	Price
B129580-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$19.90
B129580-5mg	5mg	In stock	$54.90
B129580-10mg	10mg	In stock	$92.90
B129580-25mg	25mg	In stock	$198.90
B129580-50mg	50mg	In stock	$282.90
B129580-100mg	100mg	In stock	$454.90
B129580-250mg	250mg	In stock	$908.90

Selective inhibitor of myosin II ATPase activity. Active enantiomer of(±)-blebbistatin(Cat. No. 1760)

View related series

FL Iodoacetamide

Basic Description

Synonyms	(-)-Blebbistatin\|856925-71-8\|(S)-(-)-Blebbistatin\|Blebbistatin, (-)-\|(S)-blebbistatin\|(-)Blebbistatin\|Blebbistatin (S)-form [MI]\|CHEBI:75388\|CHEMBL1231358\|8WII7624I5\|(S)-3a-hydroxy-6-methyl-1-phenyl-3,3a-dihydro-1H-pyrrolo[2,3-b]quinolin-4(2H)-one\|(-)-1-P
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Selective inhibitor of myosin II ATPase activity (IC50~0.5 - 5μM); active enantiomer of (±)-blebbistatin. Inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and
Storage Temp	Protected from light,Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Product Description	(-)-Blebbistatin is an S enantiomer of blebbistatin. Blebbistatin is a potent and selective myosin II inhibitor with IC50s ranging from 0.5 to 5 μM.

Associated Targets

FTL Tbio Ferritin light chain 0 Activities

Discover Target: FTL

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

Discover Target: KMT2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KAT2A Tchem Histone acetyltransferase KAT2A 0 Activities

Discover Target: KAT2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MYH2 Tbio Myosin-2 0 Activities

Discover Target: MYH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(3aS)-3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one
INCHI	InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m1/s1
InChi Key	LZAXPYOBKSJSEX-GOSISDBHSA-N
Canonical SMILES	Cc1ccc2N=C3N(CC[C@@]3(O)C(=O)c2c1)c4ccccc4
Isomeric SMILES	CC1=CC2=C(C=C1)N=C3[C@](C2=O)(CCN3C4=CC=CC=C4)O
WGK Germany	3
PubChem CID	5287792
Molecular Weight	292.33

Certificates

Certificate of Analysis(COA)

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16 results found

Lot Number	Certificate Type	Date	Item
J2210329	Certificate of Analysis	Jul 17, 2024	B129580
J2210330	Certificate of Analysis	Jul 17, 2024	B129580
J2210320	Certificate of Analysis	Jul 09, 2024	B129580
J2210198	Certificate of Analysis	Jul 09, 2024	B129580
J2210197	Certificate of Analysis	Jul 09, 2024	B129580
J2210159	Certificate of Analysis	Jul 09, 2024	B129580
F2413235	Certificate of Analysis	Jun 03, 2024	B129580
F2413236	Certificate of Analysis	Jun 03, 2024	B129580
F2413289	Certificate of Analysis	Jun 03, 2024	B129580
E2420155	Certificate of Analysis	May 13, 2024	B129580
J2115047	Certificate of Analysis	Jul 14, 2023	B129580
H1912087	Certificate of Analysis	Mar 07, 2023	B129580
C2412074	Certificate of Analysis	Aug 29, 2022	B129580
D2403038	Certificate of Analysis	Aug 29, 2022	B129580
D2424031	Certificate of Analysis	Aug 29, 2022	B129580
H2215257	Certificate of Analysis	Aug 17, 2022	B129580

Solubility

Solvent:DMSO, Max Conc. mg/mL: 29.23, Max Conc. mM: 100

Sensitivity

Light sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H317:May cause an allergic skin reaction H312:Harmful in contact with skin H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3

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