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(±)-Blebbistatin - ≥99%, high purity , CAS No.674289-55-5

5 Citations
  • ≥99%
Item Number
B275951
Grouped product items
SKUSizeAvailabilityPrice Qty
B275951-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$19.90
B275951-5mg
5mg
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Production requires sourcing of materials. We appreciate your patience and understanding.
$180.90
B275951-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$109.90
B275951-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$567.90
B275951-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$354.90
B275951-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$567.90
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Potent, selective, inhibitor of myosin II

View related series
Cytoskeleton Myosin

Basic Description

Synonyms1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one | 1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo(2.3-b)-7-methylquinolin-4-one | CHEBI:75379 | KBioGR_000194 | 6-methyl-3a-oxidanyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4
Specifications & Purity≥99%
Biochemical and Physiological MechanismsCell-permeable, reversible inhibitor of non-muscle myosin II. Shows high affinity and selectivity for vertebrate and invertebrate Myosin II (IC 50 values 0.5-5 μM). Inhibits actin-activated MgATPase activity and in vitro motility of class II myosins.
Storage TempProtected from light,Store at -20°C,Desiccated
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for more information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

HBB Tbio Hemoglobin beta chain (329 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CASP1 Tchem Caspase-1 (6235 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CASP7 Tchem Caspase-7 (3146 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MYH9 Tbio Myosin-9 (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MYH10 Tchem Myosin-10 (168 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MYH14 Tchem Myosin-14 (217 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
lef Anthrax lethal factor (7585 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Myosin-2 heavy chain, non muscle (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
mhcA Myosin-2 heavy chain (9 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MIC Myosin IC heavy chain (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MYO10 Unconventional myosin-X (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MYH7 Myosin-7 (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Myo1b Unconventional myosin-Ib (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MYH4 Myosin-4 (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MYH10 Nonmuscle myosin heavy chain (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Myo5a Unconventional myosin-Va (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
zip Myosin heavy chain, non-muscle (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one
INCHI InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3
InChi Key LZAXPYOBKSJSEX-UHFFFAOYSA-N
Canonical SMILES CC1=CC2=C(C=C1)N=C3C(C2=O)(CCN3C4=CC=CC=C4)O
Isomeric SMILES CC1=CC2=C(C=C1)N=C3C(C2=O)(CCN3C4=CC=CC=C4)O
PubChem CID 3476986
Molecular Weight 292.34

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

11 results found

Lot NumberCertificate TypeDateItem
B2419568Certificate of AnalysisDec 18, 2024 B275951
B2419569Certificate of AnalysisDec 18, 2024 B275951
B2419572Certificate of AnalysisDec 18, 2024 B275951
B2419574Certificate of AnalysisDec 18, 2024 B275951
B2419576Certificate of AnalysisDec 18, 2024 B275951
B2419579Certificate of AnalysisDec 18, 2024 B275951
B2419570Certificate of AnalysisJan 08, 2024 B275951
B2419571Certificate of AnalysisJan 08, 2024 B275951
B2419573Certificate of AnalysisJan 08, 2024 B275951
B2419578Certificate of AnalysisJan 08, 2024 B275951
B2419580Certificate of AnalysisJan 08, 2024 B275951

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Chemical and Physical Properties

SolubilitySoluble in DMSO to 100 mM
SensitivityLight sensitive

Related Documents

 SDS

 Specification Sheet

Alternative Products

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  3. (R)-(+)-Blebbistatin - ≥99%(HPLC), used for , CAS No. 1177356-70-5, by Aladdin Scientific
    (R)-(+)-Blebbistatin
    • ≥99%(HPLC)

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Citations of This Product

How to Cite Aladdin Scientific Products?
1. Chen Li, Zihui Zheng, Xiang Wu, Qiu Xie, Ping Liu, Yunfeng Hu, Mei Chen, Liming Liu, Wangxing Zhao, Linlin Chen, Jun Guo, Ying Song.  (2023)  Stiff matrix induced srGAP2 tension gradients control migration direction in triple-negative breast cancer.  Theranostics,  13  (1): ( 59–76).  [PMID:36593959] [10.7150/thno.77313]
2. Yunfeng Hu, Qiu Xie, Shanshan Chen, Wangxing Zhao, Xudong Zhao, Qinli Ruan, Zihui Zheng, Huanhuan Zhao, Tonghui Ma, Jun Guo, Lei Li.  (2022)  Par3 promotes breast cancer invasion and migration through pull tension and protein nanoparticle-induced osmotic pressure.  BIOMEDICINE & PHARMACOTHERAPY,  155  (113739).  [PMID:36179489] [10.1016/j.biopha.2022.113739]
3. Siyuan Huang, Qi Su, Xiaoqiang Hou, Kuankuan Han, Shufang Ma, Bingshe Xu, Yingjun Yang.  (2022)  Influence of Colonies’ Morphological Cues on Cellular Uptake Capacity of Nanoparticles.  Frontiers in Bioengineering and Biotechnology,  10  (922159).  [PMID:35711638] [10.3389/fbioe.2022.922159]
4. Ying Song, Chen Li, Yahan Fu, Qiu Xie, Jun Guo, Guangming Li, Huiwen Wu.  (2020)  Inward Tension of Talin and Integrin-related Osmotic Pressure are involved Synergetically in the Invasion and Metastasis of Non-small Cell Lung Cancer.  Journal of Cancer,  11  (17): ( 5032–5041).  [PMID:32742451] [10.7150/jca.45494]
5. Yifan Wang, Xiaolong Zhang, Jilai Tian, Jinjun Shan, Yunfeng Hu, Yiqian Zhai, Jun Guo.  (2019)  Talin promotes integrin activation accompanied by generation of tension in talin and an increase in osmotic pressure in neurite outgrowth.  FASEB JOURNAL,  33  (5): (6311-6326).  [PMID:30768370] [10.1096/fj.201801949RR]

References

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5. Stanton AE et al..  (2019)  Biochemical Ligand Density Regulates Yes-Associated Protein Translocation in Stem Cells through Cytoskeletal Tension and Integrins..  ACS Appl Mater Interfaces,  11  (9): (8849-8857).  [PMID:30789697]
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25. Hu X et al..  (2019)  Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia..  Elife,  8    [PMID:31486771]
26. Zarkoob H et al..  (2018)  Substrate deformations induce directed keratinocyte migration..  J R Soc Interface,  15  (143):   [PMID:29899159]
27. Zhovmer AS et al..  (2019)  The role of nonmuscle myosin 2A and 2B in the regulation of mesenchymal cell contact guidance..  Mol Biol Cell,  30  (16): (1961-1973).  [PMID:31318315]
28. Seifert J et al..  (2017)  Thrombin-induced cytoskeleton dynamics in spread human platelets observed with fast scanning ion conductance microscopy..  Sci Rep,  7  (4810).  [PMID:28684746]
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30. Chen Li, Zihui Zheng, Xiang Wu, Qiu Xie, Ping Liu, Yunfeng Hu, Mei Chen, Liming Liu, Wangxing Zhao, Linlin Chen, Jun Guo, Ying Song.  (2023)  Stiff matrix induced srGAP2 tension gradients control migration direction in triple-negative breast cancer.  Theranostics,  13  (1): ( 59–76).  [PMID:36593959] [10.7150/thno.77313]
31. Yunfeng Hu, Qiu Xie, Shanshan Chen, Wangxing Zhao, Xudong Zhao, Qinli Ruan, Zihui Zheng, Huanhuan Zhao, Tonghui Ma, Jun Guo, Lei Li.  (2022)  Par3 promotes breast cancer invasion and migration through pull tension and protein nanoparticle-induced osmotic pressure.  BIOMEDICINE & PHARMACOTHERAPY,  155  (113739).  [PMID:36179489] [10.1016/j.biopha.2022.113739]
32. Siyuan Huang, Qi Su, Xiaoqiang Hou, Kuankuan Han, Shufang Ma, Bingshe Xu, Yingjun Yang.  (2022)  Influence of Colonies’ Morphological Cues on Cellular Uptake Capacity of Nanoparticles.  Frontiers in Bioengineering and Biotechnology,  10  (922159).  [PMID:35711638] [10.3389/fbioe.2022.922159]
33. Ying Song, Chen Li, Yahan Fu, Qiu Xie, Jun Guo, Guangming Li, Huiwen Wu.  (2020)  Inward Tension of Talin and Integrin-related Osmotic Pressure are involved Synergetically in the Invasion and Metastasis of Non-small Cell Lung Cancer.  Journal of Cancer,  11  (17): ( 5032–5041).  [PMID:32742451] [10.7150/jca.45494]
34. Yifan Wang, Xiaolong Zhang, Jilai Tian, Jinjun Shan, Yunfeng Hu, Yiqian Zhai, Jun Guo.  (2019)  Talin promotes integrin activation accompanied by generation of tension in talin and an increase in osmotic pressure in neurite outgrowth.  FASEB JOURNAL,  33  (5): (6311-6326).  [PMID:30768370] [10.1096/fj.201801949RR]

Solution Calculators

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