Basic Description

Synonyms	VU0285655-1 \| APV
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Potent, selective PLD2 inhibitor (IC 50 values are 90 and 500 nM for HEK293 and human cells respectively).
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

PLD1 Tchem Phospholipase D1 (469 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PLD2 Tchem Phospholipase D2 (437 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

IUPAC Name	N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]quinoline-3-carboxamide
INCHI	InChI=1S/C25H27N5O2/c31-23(20-16-19-6-4-5-9-22(19)27-17-20)26-12-15-29-13-10-25(11-14-29)24(32)28-18-30(25)21-7-2-1-3-8-21/h1-9,16-17H,10-15,18H2,(H,26,31)(H,28,32)
InChi Key	WJOCDBUFEUKYNI-UHFFFAOYSA-N
Canonical SMILES	C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCNC(=O)C4=CC5=CC=CC=C5N=C4
Isomeric SMILES	C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCNC(=O)C4=CC5=CC=CC=C5N=C4
PubChem CID	44138050
Molecular Weight	429.5

Enter Lot Number to search for COA:

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8 results found

Lot Number	Certificate Type	Date	Item
F2316511	Certificate of Analysis	May 19, 2023	N130534
F2316549	Certificate of Analysis	May 19, 2023	N130534
F2316552	Certificate of Analysis	May 19, 2023	N130534
F2316553	Certificate of Analysis	May 19, 2023	N130534
F2316555	Certificate of Analysis	May 19, 2023	N130534
F2316556	Certificate of Analysis	May 19, 2023	N130534
F2316558	Certificate of Analysis	May 19, 2023	N130534
F2316559	Certificate of Analysis	May 19, 2023	N130534

1. Chakraborti S et al.. (2019) Role of PLD-PKCζ signaling axis in p47phox phosphorylation for activation of NADPH oxidase by angiotensin II in pulmonary artery smooth muscle cells.. Cell Biol Int, 43 (6): (678-694). [PMID:30977575]

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SKU	Size	Availability	Price
N130534-1mg	1mg	In stock	$24.90
N130534-5mg	5mg	In stock	$95.90
N130534-10mg	10mg	In stock	$171.90
N130534-25mg	25mg	In stock	$384.90