Basic Description

Synonyms	BML-284 \| 853220-52-7 \| Wnt Agonist \| N4-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)pyrimidine-2,4-diamine \| N4-(Benzo[d][1,3]dioxol-5-ylmethyl)-6-(3-methoxyphenyl)pyrimidine-2,4-diamine \| 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidi
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Cell-permeable Wnt signaling activator. Induces β-catenin and TCF-dependent transcriptional activity (EC 50 = 0.7 μM). Activates Wnt without inhibiting GSK-3β.Shows developmental effects in vivo. CID 11210285 is a cell-permeable, potent and selective acti
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Application CID 11210285 has been used as a Wnt agonist

Associated Targets(Human)

TUBA3C Tchem Tubulin alpha (84 Activities)

Discover Target: TUBA3C

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TUBB4B Tclin Tubulin beta (167 Activities)

Discover Target: TUBB4B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TUBB2B Tubulin (2175 Activities)

Discover Target: TUBB2B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	4-N-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)pyrimidine-2,4-diamine
INCHI	InChI=1S/C19H18N4O3/c1-24-14-4-2-3-13(8-14)15-9-18(23-19(20)22-15)21-10-12-5-6-16-17(7-12)26-11-25-16/h2-9H,10-11H2,1H3,(H3,20,21,22,23)
InChi Key	FABQUVYDAXWUQP-UHFFFAOYSA-N
Canonical SMILES	COC1=CC=CC(=C1)C2=CC(=NC(=N2)N)NCC3=CC4=C(C=C3)OCO4
Isomeric SMILES	COC1=CC=CC(=C1)C2=CC(=NC(=N2)N)NCC3=CC4=C(C=C3)OCO4
PubChem CID	11210285
Molecular Weight	350.4

Certificates

Certificate of Analysis(COA)

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Citations of This Product

How to Cite Aladdin Scientific Products?

1. Wenqi Diao, Jin Yan, Xuedong Wang, Qiuhui Qian, Huili Wang. (2023) Mechanisms regarding cardiac toxicity triggered by up-regulation of miR-144 in larval zebrafish upon exposure to triclosan. JOURNAL OF HAZARDOUS MATERIALS, 443 (130297). [PMID:36368065]

References

1. Wenqi Diao, Jin Yan, Xuedong Wang, Qiuhui Qian, Huili Wang. (2023) Mechanisms regarding cardiac toxicity triggered by up-regulation of miR-144 in larval zebrafish upon exposure to triclosan. JOURNAL OF HAZARDOUS MATERIALS, 443 (130297). [PMID:36368065]

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BML 284 - 10mM in DMSO, high purity , CAS No.853220-52-7