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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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B414428-5mg | 5mg | In stock | $343.90 | |
B414428-10mg | 10mg | In stock | $617.90 | |
B414428-25mg | 25mg | In stock | $1,133.90 | |
B414428-50mg | 50mg | In stock | $2,025.90 | |
B414428-100mg | 100mg | In stock | $3,433.90 |
PD-1/PD-L1 Inhibitors
Specifications & Purity | ≥98% |
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Biochemical and Physiological Mechanisms | BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with EC50 of 253 nM. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. |
Storage Temp | Protected from light,Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | Information BMS-1001 BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with EC50 of 253 nM. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. Targets PD-1/PD-L1 (Cell-free assay) 253 nM(EC50) In vitro BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. BMS-1001 is effective in attenuating the inhibitory effect of the cell surface-associated PD-L1. Cell Research(from reference) Cell lines:PD-L1+ aAPC/CHO-K1 cells (aAPCs), PD-1 Effector Cells (ECs) Concentrations:0.12 μM, 0.3 μM, 1.2 μM, 3 μM Incubation Time:24 h |
ALogP | 3.03 |
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HBD Count | 2 |
Rotatable Bond | 12 |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (2R)-2-[[2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]-5-methylphenyl]methylamino]-3-hydroxypropanoic acid |
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INCHI | InChI=1S/C35H34N2O7/c1-22-13-28(18-37-30(19-38)35(39)40)33(43-20-25-6-3-5-24(14-25)17-36)16-32(22)44-21-27-7-4-8-29(23(27)2)26-9-10-31-34(15-26)42-12-11-41-31/h3-10,13-16,30,37-38H,11-12,18-21H2,1-2H3,(H,39,40)/t30-/m1/s1 |
InChi Key | UWNXGZKSIKQKAH-SSEXGKCCSA-N |
Canonical SMILES | CC1=CC(=C(C=C1OCC2=C(C(=CC=C2)C3=CC4=C(C=C3)OCCO4)C)OCC5=CC(=CC=C5)C#N)CNC(CO)C(=O)O |
Isomeric SMILES | CC1=CC(=C(C=C1OCC2=C(C(=CC=C2)C3=CC4=C(C=C3)OCCO4)C)OCC5=CC(=CC=C5)C#N)CN[C@H](CO)C(=O)O |
PubChem CID | 131839624 |
Molecular Weight | 594.65 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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L2210378 | Certificate of Analysis | Dec 26, 2022 | B414428 |
L2210370 | Certificate of Analysis | Dec 17, 2022 | B414428 |
L2210386 | Certificate of Analysis | Dec 17, 2022 | B414428 |
L2210387 | Certificate of Analysis | Dec 17, 2022 | B414428 |
L2210421 | Certificate of Analysis | Dec 17, 2022 | B414428 |
Solubility | Solubility (25°C) In vitro DMSO: 50 mg/mL (84.08 mM); Water: Insoluble; Ethanol: Insoluble; |
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Sensitivity | light sensitive |
DMSO(mg / mL) Max Solubility | 25 |
DMSO(mM) Max Solubility | 42.0415370385941 |
Water(mg / mL) Max Solubility | <1 |