BMS-1001 - 98%, high purity , CAS No.2113650-03-4

  • ≥98%
Item Number
B414428
Grouped product items
SKUSizeAvailabilityPrice Qty
B414428-5mg
5mg
In stock
$343.90
B414428-10mg
10mg
In stock
$617.90
B414428-25mg
25mg
In stock
$1,133.90
B414428-50mg
50mg
In stock
$2,025.90
B414428-100mg
100mg
In stock
$3,433.90

PD-1/PD-L1 Inhibitors

Basic Description

Specifications & Purity≥98%
Biochemical and Physiological MechanismsBMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with EC50 of 253 nM. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes.
Storage TempProtected from light,Store at -20°C
Shipped InIce chest + Ice pads
Product Description

Information

BMS-1001 BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with EC50 of 253 nM. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes.


Targets

PD-1/PD-L1 (Cell-free assay) 253 nM(EC50)


In vitro

BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. BMS-1001 is effective in attenuating the inhibitory effect of the cell surface-associated PD-L1.


Cell Research(from reference)

Cell lines:PD-L1+ aAPC/CHO-K1 cells (aAPCs), PD-1 Effector Cells (ECs) 

Concentrations:0.12 μM, 0.3 μM, 1.2 μM, 3 μM 

Incubation Time:24 h 

Product Properties

ALogP3.03
HBD Count2
Rotatable Bond12

Associated Targets(Human)

CD274 Tclin Programmed cell death 1 ligand 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Jurkat (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CD274 Tclin Programmed cell death 1 ligand 1 (299 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2R)-2-[[2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]-5-methylphenyl]methylamino]-3-hydroxypropanoic acid
INCHI InChI=1S/C35H34N2O7/c1-22-13-28(18-37-30(19-38)35(39)40)33(43-20-25-6-3-5-24(14-25)17-36)16-32(22)44-21-27-7-4-8-29(23(27)2)26-9-10-31-34(15-26)42-12-11-41-31/h3-10,13-16,30,37-38H,11-12,18-21H2,1-2H3,(H,39,40)/t30-/m1/s1
InChi Key UWNXGZKSIKQKAH-SSEXGKCCSA-N
Canonical SMILES CC1=CC(=C(C=C1OCC2=C(C(=CC=C2)C3=CC4=C(C=C3)OCCO4)C)OCC5=CC(=CC=C5)C#N)CNC(CO)C(=O)O
Isomeric SMILES CC1=CC(=C(C=C1OCC2=C(C(=CC=C2)C3=CC4=C(C=C3)OCCO4)C)OCC5=CC(=CC=C5)C#N)CN[C@H](CO)C(=O)O
PubChem CID 131839624
Molecular Weight 594.65

Certificates

Certificate of Analysis(COA)

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5 results found

Lot NumberCertificate TypeDateItem
L2210378Certificate of AnalysisDec 26, 2022 B414428
L2210370Certificate of AnalysisDec 17, 2022 B414428
L2210386Certificate of AnalysisDec 17, 2022 B414428
L2210387Certificate of AnalysisDec 17, 2022 B414428
L2210421Certificate of AnalysisDec 17, 2022 B414428

Chemical and Physical Properties

SolubilitySolubility (25°C) In vitro DMSO: 50 mg/mL (84.08 mM); Water: Insoluble; Ethanol: Insoluble;
Sensitivitylight sensitive
DMSO(mg / mL) Max Solubility25
DMSO(mM) Max Solubility42.0415370385941
Water(mg / mL) Max Solubility<1

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