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BMS 453 - ≥98%(HPLC), high purity , CAS No.166977-43-1
Synthetic retinoid and RARβ agonist; also RARα and RARγ antagonist
Basic Description Synonyms (E)-4-(2-(5,5-Dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)vinyl)benzoicacid | E)-4-[2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid | (E)-4-[2-(5,5-Dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)vinyl]benzoic acid | 4-[(1E)-2-(5,6 Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms BMS-189453 is a potent RARβ agonist that acts as an antagonist against RARα and RARγ. BMS-189453 induces RARβ reporter gene expression at sub nanomolar levels, and is 30 fold more potent than all-trans retinoic acid for inducing TGFβ activity in normal br Storage Temp Store at -20°C,Argon charged Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 4-[(E)-2-(5,5-dimethyl-8-phenyl-6H-naphthalen-2-yl)ethenyl]benzoic acid INCHI InChI=1S/C27H24O2/c1-27(2)17-16-23(21-6-4-3-5-7-21)24-18-20(12-15-25(24)27)9-8-19-10-13-22(14-11-19)26(28)29/h3-16,18H,17H2,1-2H3,(H,28,29)/b9-8+ InChi Key VUODRPPTYLBGFM-CMDGGOBGSA-N Canonical SMILES CC1(CC=C(C2=C1C=CC(=C2)C=CC3=CC=C(C=C3)C(=O)O)C4=CC=CC=C4)C Isomeric SMILES CC1(CC=C(C2=C1C=CC(=C2)/C=C/C3=CC=C(C=C3)C(=O)O)C4=CC=CC=C4)C PubChem CID 9875424 Molecular Weight 380.48
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 38.05, Max Conc. mM: 100
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