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BMS 493 - ≥98%(HPLC), high purity , CAS No.215030-90-3, Antagonist of Retinoic acid receptor-α;Antagonist of Retinoic acid receptor-β;Antagonist of Retinoic acid receptor-γ;Agonist of TLX
Basic Description Synonyms BMS 493 | 215030-90-3 | BMS493 | BMS-493 | BMS-204493 | 4-{(E)-2-[5,5-dimethyl-8-(phenylethynyl)-5,6-dihydronaphthalen-2-yl]ethenyl}benzoic acid | CHEMBL472172 | 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoic acid | 4-[(E)-2-[5,5-d Specifications & Purity Moligand™, ≥98%(HPLC) Biochemical and Physiological Mechanisms Pan-retinoic acid receptor (pan-RAR) inverse agonist. Enhances nuclear corepressor (NCoR) interaction with RARs. Binding induces analogous conformational changes in all RAR types (RARα, RARβand RARγ). Storage Temp Store at 2-8°C Shipped In Wet ice Grade Moligand™ Action Type AGONIST, ANTAGONIST Mechanism of action Antagonist of Retinoic acid receptor-α;Antagonist of Retinoic acid receptor-β;Antagonist of Retinoic acid receptor-γ;Agonist of TLX
Associated Targets(Human) Names and Identifiers IUPAC Name 4-[(E)-2-[5,5-dimethyl-8-(2-phenylethynyl)-6H-naphthalen-2-yl]ethenyl]benzoic acid INCHI InChI=1S/C29H24O2/c1-29(2)19-18-24(14-10-21-6-4-3-5-7-21)26-20-23(13-17-27(26)29)9-8-22-11-15-25(16-12-22)28(30)31/h3-9,11-13,15-18,20H,19H2,1-2H3,(H,30,31)/b9-8+ InChi Key YCADIXLLWMXYKW-CMDGGOBGSA-N Canonical SMILES CC1(CC=C(C2=C1C=CC(=C2)C=CC3=CC=C(C=C3)C(=O)O)C#CC4=CC=CC=C4)C Isomeric SMILES CC1(CC=C(C2=C1C=CC(=C2)/C=C/C3=CC=C(C=C3)C(=O)O)C#CC4=CC=CC=C4)C PubChem CID 9909190 Molecular Weight 404.5
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 40.45, Max Conc. mM: 100
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