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BMS-687453 - 10mM in DMSO, high purity , CAS No.1000998-59-3
PPARα Selective Inhibitors | Activators | Agonists | Antagonists
Basic Description
| Synonyms | BMS-687453 | 1000998-59-3 | Glycine, N-[[3-[[2-(4-chlorophenyl)-5-methyl-4-oxazolyl]methoxy]phenyl]methyl]-N-(methoxycarbonyl)- | BMS 687453 | 39TL5L7XDX | N-(3-((2-(4-Chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)-N-(methoxycarbonyl)glycine | 2-[[3-[[2-(4-chlorop |
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| Specifications & Purity | 10mM in DMSO |
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| Biochemical and Physiological Mechanisms | BMS-687453 (compound 2) is a potent and selective agonist of PPARα with EC50 of 10 nM and IC50 of 260 nM for human PPARα. |
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| Storage Temp | Store at -80°C |
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| Shipped In | Ice chest + Ice pads |
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| Product Description | Information BMS-687453 (compound 2) is a potent and selective agonist ofPPARαwith EC50 of 10 nM and IC50 of 260 nM for human PPARα. Targets PPARα (Cell-free assay); PPARα (Cell-free assay) 10 nM(EC50); 260 nM |
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Product Properties
| ALogP | 3.702 |
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| Rotatable Bond | 9 |
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | 2-[[3-[[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy]phenyl]methyl-methoxycarbonylamino]acetic acid |
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| INCHI | InChI=1S/C22H21ClN2O6/c1-14-19(24-21(31-14)16-6-8-17(23)9-7-16)13-30-18-5-3-4-15(10-18)11-25(12-20(26)27)22(28)29-2/h3-10H,11-13H2,1-2H3,(H,26,27) |
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| InChi Key | UJIBXDMNCMEJAY-UHFFFAOYSA-N |
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| Canonical SMILES | CC1=C(N=C(O1)C2=CC=C(C=C2)Cl)COC3=CC=CC(=C3)CN(CC(=O)O)C(=O)OC |
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| Isomeric SMILES | CC1=C(N=C(O1)C2=CC=C(C=C2)Cl)COC3=CC=CC(=C3)CN(CC(=O)O)C(=O)OC |
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| PubChem CID | 16725047 |
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| Molecular Weight | 444.86 |
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Chemical and Physical Properties
| DMSO(mg / mL) Max Solubility | 89 |
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| DMSO(mM) Max Solubility | 200.062941150025 |
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| Water(mg / mL) Max Solubility | ＜1 |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
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| Signal | Warning |
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| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
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| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. |
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