BMS-820132 , CAS No.B608139, Activator of Glucokinase

Item Number

B608139

Grouped product items
SKU	Size	Availability	Price
B608139-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$479.90
B608139-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$739.90
B608139-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,299.90
B608139-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,639.90

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Basic Description

Synonyms	BMS820132;compound 31
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at 2-8°C,Protected from light
Shipped In	Wet ice
Grade	Moligand™
Action Type	ACTIVATOR
Mechanism of action	Activator of Glucokinase
Product Description	BMS-820132 is an partial glucokinase (GK) activator with a AC50 of 29 nM. BMS-820132 decreases the glucose levels in glucose tolerance test (OGTT) model in normal rats, but not Zucker diabetic fatty (ZDF) rats. BMS-820132 exhibits pharmacological toxicity secondary to strong GK activation

Canonical SMILES

O=C(NC1=NN(CP(OCC)(OCC)=O)C=C1)C2=CC(OC(C)C)=CC(OC3=NC=C(C(N4CCC4)=O)N=C3)=C2

Molecular Weight

572.55

PubChem CID

RCSB PDB Ligand

References

1. Shi Y, Wang Y, Meng W, Brigance RP, Ryono DE, Bolton S, Zhang H, Chen S, Smirk R, Tao S et al.. (2022) Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132).. J Med Chem, 65 (5): (4291-4317). [PMID:35179904] [10.1021/op500134e]

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Basic Description