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BMS-833923 - 98%, high purity , Smoothened homolog antagonist, CAS No.1059734-66-5, Smoothened homolog antagonist

Item Number
B126389
Grouped product items
SKUSizeAvailabilityPrice Qty
B126389-5mg
5mg
In stock
$54.90
B126389-10mg
10mg
In stock
$90.90
B126389-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$252.90
B126389-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,138.90

Potent Smoothened antagonist

View related series
Smo Stem Cell/Wnt

Basic Description

SynonymsN-(2-methyl-5-((methylamino)methyl)phenyl)-4-((4-phenylquinazolin-2-yl)amino)benzamide. | Q27075373 | BCP07837 | SW219814-1 | GTPL8202 | 41J7ZJ239R | Benzamide, N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]- | MFCD25976660
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsDescription:
IC50 Value: 6-35 nM [1]
BMS-833923 (or XL-139) is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. SMO antagonist BMS-833923 inhibits the sonic hedgehog (SHH) pathway protein S
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionSmoothened homolog antagonist
NoteToxic, refer to SDS for further information . Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Properties

ALogP5.7

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Schistosoma mansoni (6170 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name N-[2-methyl-5-(methylaminomethyl)phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide
INCHI InChI=1S/C30H27N5O/c1-20-12-13-21(19-31-2)18-27(20)33-29(36)23-14-16-24(17-15-23)32-30-34-26-11-7-6-10-25(26)28(35-30)22-8-4-3-5-9-22/h3-18,31H,19H2,1-2H3,(H,33,36)(H,32,34,35)
InChi Key KLRRGBHZCJLIEL-UHFFFAOYSA-N
Canonical SMILES CC1=C(C=C(C=C1)CNC)NC(=O)C2=CC=C(C=C2)NC3=NC4=CC=CC=C4C(=N3)C5=CC=CC=C5
Isomeric SMILES CC1=C(C=C(C=C1)CNC)NC(=O)C2=CC=C(C=C2)NC3=NC4=CC=CC=C4C(=N3)C5=CC=CC=C5
PubChem CID 57662985
Molecular Weight 473.57

Certificates

Certificate of Analysis(COA)

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4 results found

Lot NumberCertificate TypeDateItem
J2115367Certificate of AnalysisJul 07, 2023 B126389
J2115389Certificate of AnalysisJul 07, 2023 B126389
J2115429Certificate of AnalysisJul 07, 2023 B126389
J2115431Certificate of AnalysisJul 07, 2023 B126389

Chemical and Physical Properties

SolubilityDMSO 95 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

Related Documents

References

1. Sandhiya S, Melvin G, Kumar SS, Dkhar SA.  (2013)  The dawn of hedgehog inhibitors: Vismodegib..  J Pharmacol Pharmacother,  (1): (4-7).  [PMID:23662017] [10.1021/op500134e]
2. Akare UR, Bandaru S, Shaheen U, Singh PK, Tiwari G, Singare P, Nayarisseri A, Banerjee T.  (2014)  Molecular docking approaches in identification of High affinity inhibitors of Human SMO receptor..  Bioinformation,  10  (12): (737-42).  [PMID:25670876] [10.1021/op500134e]

Solution Calculators