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SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
B126389-5mg | 5mg | In stock | $54.90 | |
B126389-10mg | 10mg | In stock | $90.90 | |
B126389-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $252.90 | |
B126389-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,138.90 |
Potent Smoothened antagonist
Synonyms | N-(2-methyl-5-((methylamino)methyl)phenyl)-4-((4-phenylquinazolin-2-yl)amino)benzamide. | Q27075373 | BCP07837 | SW219814-1 | GTPL8202 | 41J7ZJ239R | Benzamide, N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]- | MFCD25976660 |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Description: IC50 Value: 6-35 nM [1] BMS-833923 (or XL-139) is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. SMO antagonist BMS-833923 inhibits the sonic hedgehog (SHH) pathway protein S |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Smoothened homolog antagonist |
Note | Toxic, refer to SDS for further information . Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
ALogP | 5.7 |
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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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IUPAC Name | N-[2-methyl-5-(methylaminomethyl)phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide |
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INCHI | InChI=1S/C30H27N5O/c1-20-12-13-21(19-31-2)18-27(20)33-29(36)23-14-16-24(17-15-23)32-30-34-26-11-7-6-10-25(26)28(35-30)22-8-4-3-5-9-22/h3-18,31H,19H2,1-2H3,(H,33,36)(H,32,34,35) |
InChi Key | KLRRGBHZCJLIEL-UHFFFAOYSA-N |
Canonical SMILES | CC1=C(C=C(C=C1)CNC)NC(=O)C2=CC=C(C=C2)NC3=NC4=CC=CC=C4C(=N3)C5=CC=CC=C5 |
Isomeric SMILES | CC1=C(C=C(C=C1)CNC)NC(=O)C2=CC=C(C=C2)NC3=NC4=CC=CC=C4C(=N3)C5=CC=CC=C5 |
PubChem CID | 57662985 |
Molecular Weight | 473.57 |
PubChem CID | 57662985 |
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CAS Registry No. | 1059734-66-5 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
4 results found
Lot Number | Certificate Type | Date | Item |
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J2115367 | Certificate of Analysis | Jul 07, 2023 | B126389 |
J2115389 | Certificate of Analysis | Jul 07, 2023 | B126389 |
J2115429 | Certificate of Analysis | Jul 07, 2023 | B126389 |
J2115431 | Certificate of Analysis | Jul 07, 2023 | B126389 |
Solubility | DMSO 95 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
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1. Sandhiya S, Melvin G, Kumar SS, Dkhar SA. (2013) The dawn of hedgehog inhibitors: Vismodegib.. J Pharmacol Pharmacother, 4 (1): (4-7). [PMID:23662017] [10.1021/op500134e] |
2. Akare UR, Bandaru S, Shaheen U, Singh PK, Tiwari G, Singare P, Nayarisseri A, Banerjee T. (2014) Molecular docking approaches in identification of High affinity inhibitors of Human SMO receptor.. Bioinformation, 10 (12): (737-42). [PMID:25670876] [10.1021/op500134e] |