Bobcat339 - 98%, high purity , CAS No.2280037-51-4

Item Number

B413583

Grouped product items
SKU	Size	Availability	Price
B413583-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$10.90
B413583-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$30.90
B413583-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$49.90
B413583-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$99.90
B413583-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$159.90
B413583-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$255.90

DNA Methyltransferase Inhibitors

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Basic Description

Synonyms	4-Amino-1-[1,1'-biphenyl]-3-yl-5-chloro-2(1H)-pyrimidinone
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Bobcat339 is a selective cytosine-based inhibitor of ten-eleven translocation methylcytosine dioxygenase (TET) (IC50 values are 33 and 73 μM for TET1 and TET2, respectively). Bobcat339 reduces DNA 5-hydroxymethylcytosine (5hmC) levels in cells without inh
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription

Associated Targets(Human)

DNMT3A Tclin DNA (cytosine-5)-methyltransferase 3A (310 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TET2 Tchem Methylcytosine dioxygenase TET2 (57 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TET1 Tbio Methylcytosine dioxygenase TET1 (33 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	4-amino-5-chloro-1-(3-phenylphenyl)pyrimidin-2-one
INCHI	InChI=1S/C16H12ClN3O/c17-14-10-20(16(21)19-15(14)18)13-8-4-7-12(9-13)11-5-2-1-3-6-11/h1-10H,(H2,18,19,21)
InChi Key	QMGYGOOYCNTEQO-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C=C1)C2=CC(=CC=C2)N3C=C(C(=NC3=O)N)Cl
Isomeric SMILES	C1=CC=C(C=C1)C2=CC(=CC=C2)N3C=C(C(=NC3=O)N)Cl
PubChem CID	138319673
Molecular Weight	297.74

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Basic Description