BPH-715 , CAS No.1059677-23-4, Inhibitor of geranylgeranyl diphosphate synthase

Item Number
B608194
Grouped product items
SKUSizeAvailabilityPrice Qty
B608194-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$159.90
B608194-5mg
5mg
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Production requires sourcing of materials. We appreciate your patience and understanding.
$359.90
B608194-10mg
10mg
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$569.90
B608194-25mg
25mg
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$899.90
B608194-50mg
50mg
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$1,119.90

Basic Description

SynonymsBPH-715 | 1059677-23-4 | BPH715 | UNII-YD43M7UAP4 | YD43M7UAP4 | Pyridinium, 3-(decyloxy)-1-(2,2-diphosphonoethyl)-, inner salt | 3-(decyloxy)-1-(2-hydrogen phosphonato-2-phosphonoethyl)pyridin-1-ium | hydrogen (2-(3-(decyloxy)pyridin-1-ium-1-yl)-1-phosphonoethyl)phosp
Specifications & PurityMoligand™, ≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of geranylgeranyl diphosphate synthase
Product Description

BPH-715 is a bisphosphonate, inhibits Plasmodium liver-stage growth, with an IC50 of 10 μM for Plasmodium exoerythrocytic forms in HepG2 cells.

Associated Targets(Human)

GGPS1 Tchem Geranylgeranyl pyrophosphate synthase (6 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FDPS Tclin Farnesyl pyrophosphate synthase (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FDPS Tclin Farnesyl diphosphate synthase (1240 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GGPS1 Tchem Geranylgeranyl pyrophosphate synthetase (715 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium berghei (192651 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name [2-(3-decoxypyridin-1-ium-1-yl)-1-phosphonoethyl]-hydroxyphosphinate
INCHI InChI=1S/C17H31NO7P2/c1-2-3-4-5-6-7-8-9-13-25-16-11-10-12-18(14-16)15-17(26(19,20)21)27(22,23)24/h10-12,14,17H,2-9,13,15H2,1H3,(H3-,19,20,21,22,23,24)
InChi Key QYJHUOZDBUEKQC-UHFFFAOYSA-N
Canonical SMILES CCCCCCCCCCOC1=C[N+](=CC=C1)CC(P(=O)(O)O)P(=O)(O)[O-]
Isomeric SMILES CCCCCCCCCCOC1=C[N+](=CC=C1)CC(P(=O)(O)O)P(=O)(O)[O-]
Alternate CAS 1059677-23-4
PubChem CID 25014899
Molecular Weight 423.38

Certificates

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