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BPTES - ≥95%(HPLC), high purity , CAS No.314045-39-1
Selective allosteric glutaminase (GLS1) inhibitor
Basic Description Synonyms BPTES | 314045-39-1 | Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide | N,N'-((thiobis(ethane-2,1-diyl))bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide) | N,N'-[sulfanediylbis(Ethane-2,1-Diyl-1,3,4-Thiadiazole-5,2-Diyl)]bis(2-Phenylacetamide) | 3 Specifications & Purity ≥95%(HPLC) Biochemical and Physiological Mechanisms Allosteric glutaminase (GLS1) inhibitor (IC50= 3.3μM). Selective for GLS1 over GLS2 andγ-glutamyl transpeptidase. Induces cell death of P493 human lymphoma B cellsin vitroand reduces tumor volume of P493 cell xenografts in mice.
Vaccinia virus (VACV) requ Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description Product application:
Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) has been used as a glutaminase inhibitor.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 2-phenyl-N-[5-[2-[2-[5-[(2-phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]ethylsulfanyl]ethyl]-1,3,4-thiadiazol-2-yl]acetamide INCHI InChI=1S/C24H24N6O2S3/c31-19(15-17-7-3-1-4-8-17)25-23-29-27-21(34-23)11-13-33-14-12-22-28-30-24(35-22)26-20(32)16-18-9-5-2-6-10-18/h1-10H,11-16H2,(H,25,29,31)(H,26,30,32) InChi Key MDJIPXYRSZHCFS-UHFFFAOYSA-N Canonical SMILES C1=CC=C(C=C1)CC(=O)NC2=NN=C(S2)CCSCCC3=NN=C(S3)NC(=O)CC4=CC=CC=C4 Isomeric SMILES C1=CC=C(C=C1)CC(=O)NC2=NN=C(S2)CCSCCC3=NN=C(S3)NC(=O)CC4=CC=CC=C4 WGK Germany 3 PubChem CID 3372016 Molecular Weight 524.68
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 10.49, Max Conc. mM: 20
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3 RIDADR NONHforallmodesoftransport
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