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Bradykinin - >98%, high purity , CAS No.58-82-2, Agonist of B 1 receptor;Agonist of B 2 receptor

2 Citations
Item Number
B304069
Grouped product items
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B304069-10mg
10mg
In stock
$79.90
B304069-50mg
50mg
In stock
$249.90
B304069-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$399.90
B304069-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$879.90
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Endogenous agonist at bradykinin receptors (B2> B1)

View related series
B1 receptor Agonist B2 receptor Agonist Bradykinin Receptor Endogenous Metabolite GPCR/G Protein Metabolic Enzyme/Protease Ser/Thr Protease

Basic Description

SynonymsSynthetic bradykinin | L-Bradykinin | PRS 640 | Kallidin I | RPPGFSPFR | Bradykinin (synthetic) | BRS 640 | Callidin I | BRADYKININ | (2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrroli
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsEndogenous bradykinin receptor agonist that displays selectivity for B2over B1receptors. Proinflammatory peptide.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of B 1 receptor;Agonist of B 2 receptor
Product Description

Bradykinin is an active peptide that is generated by the kallikrein-kinin system. It is a inflammatory mediator and also recognized as a neuromediator and regulator of several vascular and renal functions.

Associated Targets(Human)

BDKRB2 Tclin B2 bradykinin receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
BDKRB1 Tchem B1 bradykinin receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ACE Tclin Angiotensin-converting enzyme (1423 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BDKRB2 Tclin Bradykinin B2 receptor (3970 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Bdkrb1 Bradykinin B1 receptor (77 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cavia porcellus (23802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Canis familiaris (36305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Sus scrofa (849 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Oryctolagus cuniculus (11301 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium gallinaceum (527 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
INCHI InChI=1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
InChi Key QXZGBUJJYSLZLT-FDISYFBBSA-N
Canonical SMILES C1CC(N(C1)C(=O)C2CCCN2C(=O)C(CCCN=C(N)N)N)C(=O)NCC(=O)NC(CC3=CC=CC=C3)C(=O)NC(CO)C(=O)N4CCCC4C(=O)NC(CC5=CC=CC=C5)C(=O)NC(CCCN=C(N)N)C(=O)O
Isomeric SMILES C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)N)C(=O)NCC(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CO)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O
Alternate CAS 58-82-2,5979-11-3 (triacetate (salt))
PubChem CID 439201
MeSH Entry Terms Arg Pro Pro Gly Phe Ser Pro Phe Arg;Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg;Bradykinin;Bradykinin Acetate, (9-D-Arg)-Isomer;Bradykinin Diacetate;Bradykinin Hydrochloride;Bradykinin Triacetate;Bradykinin, (1-D-Arg)-Isomer;Bradykinin, (2-D-Pro)-Isomer;Bradykini
Molecular Weight 1060.21

Certificates

Certificate of Analysis(COA)

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9 results found

Lot NumberCertificate TypeDateItem
J2415272Certificate of AnalysisSep 19, 2024 B304069
J2415401Certificate of AnalysisSep 19, 2024 B304069
J2415402Certificate of AnalysisSep 19, 2024 B304069
J2415403Certificate of AnalysisSep 19, 2024 B304069
J2415404Certificate of AnalysisSep 19, 2024 B304069
K2414089Certificate of AnalysisSep 19, 2024 B304069
D2109113Certificate of AnalysisFeb 06, 2024 B304069
D2109124Certificate of AnalysisFeb 06, 2024 B304069
C2317437Certificate of AnalysisApr 17, 2023 B304069

Chemical and Physical Properties

SolubilitySoluble to 1 (mg/mL) in water}

Related Documents

 SDS

 Specification Sheet

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Citations of This Product

How to Cite Aladdin Scientific Products?
1. Jiawen Ai, Weize Zhao, Quan Yu, Xiang Qian, Jianhua Zhou, Xinming Huo, Fei Tang.  (2023)  SR-Unet: A Super-Resolution Algorithm for Ion Trap Mass Spectrometers Based on the Deep Neural Network.  ANALYTICAL CHEMISTRY,  95  (47): (17407–17415).  [PMID:37963290] [10.1021/acs.analchem.3c04172]
2. Xi-Tian Peng, Bi-Feng Yuan, Yu-Qi Feng.  (2011)  Grafting of silica with a hydrophilic triol acrylamide polymer via surface-initiated “grafting from” method for hydrophilic-interaction chromatography.  JOURNAL OF SEPARATION SCIENCE,  34  (22): (3123-3130).  [PMID:21998034] [10.1002/jssc.201100570]

References

1. Jiawen Ai, Weize Zhao, Quan Yu, Xiang Qian, Jianhua Zhou, Xinming Huo, Fei Tang.  (2023)  SR-Unet: A Super-Resolution Algorithm for Ion Trap Mass Spectrometers Based on the Deep Neural Network.  ANALYTICAL CHEMISTRY,  95  (47): (17407–17415).  [PMID:37963290] [10.1021/acs.analchem.3c04172]
2. Xi-Tian Peng, Bi-Feng Yuan, Yu-Qi Feng.  (2011)  Grafting of silica with a hydrophilic triol acrylamide polymer via surface-initiated “grafting from” method for hydrophilic-interaction chromatography.  JOURNAL OF SEPARATION SCIENCE,  34  (22): (3123-3130).  [PMID:21998034] [10.1002/jssc.201100570]

Solution Calculators

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