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Branaplam (LMI070) - 2mM in DMSO, high purity , CAS No.1562338-42-4
Basic Description Synonyms Branaplam | LMI070 | 1562338-42-4 | NVS-SM1 | LMI-070 | NVP-LMI070-NX | Branaplam [INN] | Branaplam [USAN] | 5-(1H-pyrazol-4-yl)-2-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)phenol | LMI070 (NVS-SM1) | P12R69543A | 5-(1H-pyrazol-4-yl)-2-[6-(2,2,6,6-tetramethylpi Specifications & Purity 2mM in DMSO Biochemical and Physiological Mechanisms Branaplam (LMI070) is a highly selective, small-molecule splicing modulators of survival motor neuron‑2 (SMN2) with an EC50 of 0.02 μM. Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description Information
Branaplam (LMI070) Branaplam (LMI070) is a highly selective, small-molecule splicing modulators of survival motor neuron‑2 (SMN2) with an EC50 of 0.02 μM.
Targets
SMN2 0.02 μM(EC50)
Product Properties ALogP 3.141 HBD Count 3 Rotatable Bond 4
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 5-(1H-pyrazol-4-yl)-2-[6-(2,2,6,6-tetramethylpiperidin-4-yl)oxypyridazin-3-yl]phenol INCHI InChI=1S/C22H27N5O2/c1-21(2)10-16(11-22(3,4)27-21)29-20-8-7-18(25-26-20)17-6-5-14(9-19(17)28)15-12-23-24-13-15/h5-9,12-13,16,27-28H,10-11H2,1-4H3,(H,23,24) InChi Key STWTUEAWRAIWJG-UHFFFAOYSA-N Canonical SMILES CC1(CC(CC(N1)(C)C)OC2=NN=C(C=C2)C3=C(C=C(C=C3)C4=CNN=C4)O)C Isomeric SMILES CC1(CC(CC(N1)(C)C)OC2=NN=C(C=C2)C3=C(C=C(C=C3)C4=CNN=C4)O)C PubChem CID 135565042 Molecular Weight 393.48
Chemical and Physical Properties Sensitivity Moisture sensitive DMSO(mg / mL) Max Solubility 3 DMSO(mM) Max Solubility 7.62427569380909 Water(mg / mL) Max Solubility ＜1
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H302: Harmful if swallowed
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
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