Grouped product items

SKU

Size

Availability

Price

Qty

B405327-20mg

20mg

In stock

$159.90

B405327-100mg

100mg

In stock

$376.90

Basic Description

Synonyms	BCP06006 \| brequinarum \| EX-A1515 \| 2-(2'-Fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methyl-4-quinolinecarboxylic acid \| 4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl- \| DTXSID00242165 \| DUP785; Biphenquinate; BPQ \| NCGC004807
Specifications & Purity	Moligand™, ≥98%(HPLC)
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Dihydroorotate dehydrogenase inhibitor
Product Description	Product Describtion: Brequinar (DUP785, NSC 368390) is an inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of ∼20 nM in vitro.

Product Properties

ALogP	5.6

Associated Targets(Human)

DHFR Tclin Dihydrofolate reductase (1 Activities)

Discover Target: DHFR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DHODH Tclin Dihydroorotate dehydrogenase (quinone), mitochondrial (22 Activities)

Discover Target: DHODH

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DHFR Tclin Dihydrofolate reductase (3072 Activities)

Discover Target: DHFR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DHODH Tclin Dihydroorotate dehydrogenase (2737 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 Activities)

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A-375 (9258 Activities)

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A498 (42825 Activities)

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ACHN (49357 Activities)

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CAKI-1 (44928 Activities)

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CCRF-CEM (65223 Activities)

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COLO 205 (50209 Activities)

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DU-145 (51482 Activities)

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HL-60 (67320 Activities)

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HT-1080 (3966 Activities)

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HT-29 (80576 Activities)

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K562 (73714 Activities)

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KM12 (47707 Activities)

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M14 (47487 Activities)

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MCF7 (126967 Activities)

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MDA-MB-468 (9477 Activities)

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MOLT-4 (49676 Activities)

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NAMALVA (207 Activities)

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OVCAR-3 (48710 Activities)

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OVCAR-4 (44535 Activities)

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OVCAR-5 (45555 Activities)

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OVCAR-8 (47708 Activities)

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PC-3 (62116 Activities)

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Raji (5516 Activities)

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RPMI-8226 (44974 Activities)

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RXF 393 (41971 Activities)

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SF-295 (48000 Activities)

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SK-MEL-2 (46422 Activities)

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SK-MEL-28 (48833 Activities)

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SK-MEL-5 (47095 Activities)

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SK-OV-3 (52876 Activities)

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SN12C (47755 Activities)

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SNB-19 (46794 Activities)

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THP-1 (11052 Activities)

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TK-10 (45540 Activities)

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U-251 (51189 Activities)

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U-937 (7138 Activities)

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UACC-257 (46019 Activities)

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UACC-62 (47335 Activities)

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UO-31 (46270 Activities)

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786-0 (47912 Activities)

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A549 (127892 Activities)

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NCI/ADR-RES (33767 Activities)

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T47D (39041 Activities)

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MIA PaCa-2 (5949 Activities)

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NCI-H322M (45589 Activities)

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HCC 2998 (41480 Activities)

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HCT-116 (91556 Activities)

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Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

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Rattus norvegicus (775804 Activities)

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West Nile virus (623 Activities)

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Yellow fever virus (1530 Activities)

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Measles morbillivirus (693 Activities)

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Vesicular stomatitis virus (4460 Activities)

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Influenza A virus (11224 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Dengue virus (413 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Dihydroorotate dehydrogenase (quinone), mitochondrial (90 Activities)

Discover Target:

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

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Western equine encephalitis virus (28 Activities)

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Names and Identifiers

IUPAC Name	6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid
INCHI	InChI=1S/C23H15F2NO2/c1-13-21(23(27)28)18-12-16(24)10-11-20(18)26-22(13)15-8-6-14(7-9-15)17-4-2-3-5-19(17)25/h2-12H,1H3,(H,27,28)
InChi Key	PHEZJEYUWHETKO-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C2=C(C=CC(=C2)F)N=C1C3=CC=C(C=C3)C4=CC=CC=C4F)C(=O)O
Isomeric SMILES	CC1=C(C2=C(C=CC(=C2)F)N=C1C3=CC=C(C=C3)C4=CC=CC=C4F)C(=O)O
PubChem CID	57030
Molecular Weight	375.37
Reaxy-Rn	8354757

Database links

ChEMBL Ligand	CHEMBL38434
CAS Registry No.	96187-53-0
DrugBank Ligand	DB03523
PubChem CID	57030
RCSB PDB Ligand	BRF

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
H2408224	Certificate of Analysis	Jul 31, 2024	B405327
H2408272	Certificate of Analysis	Jul 31, 2024	B405327
G2214188	Certificate of Analysis	Jun 13, 2022	B405327
G2214189	Certificate of Analysis	Jun 13, 2022	B405327

Chemical and Physical Properties

Solubility	Insoluble in water and ethanol;37 mg/mL(98.57 mM) in DMSO
Sensitivity	Heat Sensitive
Melt Point(°C)	317 °C

Safety and Hazards(GHS)

Reaxy-Rn	8354757

Alternative Products

References

1. Peters GJ, Sharma SL, Laurensse E, Pinedo HM. (1987) Inhibition of pyrimidine de novo synthesis by DUP-785 (NSC 368390).. Invest New Drugs, 5 (3): (235-44). [PMID:2822596]
2. Arteaga CL, Brown TD, Kuhn JG, Shen HS, O'Rourke TJ, Beougher K, Brentzel HJ, Von Hoff DD, Weiss GR. (1989) Phase I clinical and pharmacokinetic trial of Brequinar sodium (DuP 785; NSC 368390).. Cancer Res, 49 (16): (4648-53). [PMID:2743343]
3. Chen SF, Ruben RL, Dexter DL. (1986) Mechanism of action of the novel anticancer agent 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarbo xylic acid sodium salt (NSC 368390): inhibition of de novo pyrimidine nucleotide biosynthesis.. Cancer Res, 46 (10): (5014-9). [PMID:3019518]

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Brequinar - >98.0%(HPLC), high purity , Dihydroorotate dehydrogenase inhibitor, CAS No.96187-53-0, Dihydroorotate dehydrogenase inhibitor

Basic Description

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Alternative Products

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator