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BRG1 Mouse mAb - Primary antibody, specific to BRG1, Mouse IgG1

Features and benefits
  • Short Overview:

    mAb (6D7-F7-B6); Mouse anti Human BRG1 Antibody; WB, ICC, IF, IP; Unconjugated

  • Species reactivity(Reacts with): Human,Mouse
  • Isotype: Mouse IgG1
    Application:
  • IF/ICC
  • IP
  • WB
Item Number
Ab091716
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab091716-10μl
10μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$69.90
Ab091716-50μl
50μl
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$209.90
Ab091716-100μl
100μl
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$319.90
Ab091716-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,699.90
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mAb (6D7-F7-B6); Mouse anti Human BRG1 Antibody; WB, ICC, IF, IP; Unconjugated

View related series
Click to view target information: SMARCA4
Accession#:P51532 BRG1 Gene ID:6597 SMARCA4

Basic Description

Product NameBRG1 Mouse mAb - Primary antibody, specific to BRG1, Mouse IgG1
SynonymsATP-dependent helicase SMARCA4; BAF190; BAF190A; brahma protein-like 1; Brg1; BRG1-associated factor 190A; BRG1SWI/SNF-related matrix-associated actin-dependent regulator of chromatinsubfamily A member 4; BRM/SWI2-related gene 1; EC 3.6.1; EC 3.6.4.-; FLJ
Specifications & PurityExactAb™, Validated, Lot by Lot
Host speciesMouse
SpecificityBRG1
ImmunogenPurified recombinant human BRG1 protein fragments expressed in E.coli (AA 205-300).
Positive ControlWB: HeLa, Raw264.7, K562, Jurkat and Hep G2 cell lysates. ICC/IF: HeLa cells. IP: K562 cell lysates.
ConjugationUnconjugated
GradeExactAb™, Validated
Product Description

Mouse anti Human BRG1 Antibody, Monoclonal (6D7-F7-B6), could be used for WB, ICC, IF, IP and so on.
Application:
WB: 1/500-1/1000
ICC/IF: 1/50-1/200
IP: 1/20
Protein Function
Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1.

Product Properties

IsotypeMouse IgG1
SDS-PAGE150 kDa
Purification MethodProtein G purified
FormLiquid
ConcentrationLot by Lot
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

BRG1 Mouse mAb (Ab091716) - Western Blot
All lanes: BRG1 Mouse mAb (Ab091716) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab138040) at 1/30000 dilution

Predicted band size: 220 kDa
Observed band size: 213 kDa
Exposure time: 61.7 s

BRG1 Mouse mAb (Ab091716) - IF
Immunocytochemistry analysis of BRG1 (green) in HeLa cells using BRG1 Mouse mAb (Ab091716) and cells were counterstained with DAPI (blue).

BRG1 Mouse mAb (Ab091716) - IP
Immunoprecipitation analysis of BRG1 in K562 cell lysates using BRG1 antibody.

Associated Targets(Human)

SMARCA4 Tchem Transcription activator BRG1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SMARCA4 Tchem Transcription activator BRG1 (263 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMARCA4 Tchem VHL/Transcription activator BRG1 (12 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Application

ApplicationDilution info
WB

1/500-1/1000

ICC/IF

1/50-1/200

IP

1/20

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot NumberCertificate TypeDateItem
ZJ23F0901059Certificate of AnalysisSep 14, 2023 Ab091716
ZJ23F0901058Certificate of AnalysisSep 14, 2023 Ab091716

Related Documents

 SDS

 Specification Sheet

FAQs and Articles

FAQ
How to choose and use antibodies-primary antibody
Categories: Technical articles
Tags:
Recombinant antibody Knockout gene ICC
Immunoprecipitation (IP) lysates and reagents
Categories: Protocols
Tags:
Immunoprecipitation lysate Tissue lysate

References

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43. Sánchez-Tilló, E E and 7 more authors..  (2010)  ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1..  Oncogene,    (17):   [PMID:20418909]
44. Tando, Toshio T and 11 more authors..  (2010)  Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway..  The Journal of biological chemistry,    (16):   [PMID:20460684]
45. Rigbolt, Kristoffer T G KT and 9 more authors..  (2011)  System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation..  Science signaling,    (15):   [PMID:21406692]
46. Tsurusaki, Yoshinori Y and 30 more authors..  (2012)  Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome..  Nature genetics,    (18):   [PMID:22426308]
47. Euskirchen, Ghia G, Auerbach, Raymond K RK and Snyder, Michael M..  (2012)  SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions..  The Journal of biological chemistry,    (7):   [PMID:22952240]
48. Zhou, Houjiang H and 6 more authors..  (2013)  Toward a comprehensive characterization of a human cancer cell phosphoproteome..  Journal of proteome research,    (4):   [PMID:23186163]
49. Bian, Yangyang Y and 9 more authors..  (2014)  An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome..  Journal of proteomics,    (16):   [PMID:24275569]
50. Gong, Fade F and 11 more authors..  (2015)  Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination..  Genes & development,    (15):   [PMID:25593309]
51. Marom, Ronit R and 23 more authors..  (2017)  Heterozygous variants in ACTL6A, encoding a component of the BAF complex, are associated with intellectual disability..  Human mutation,      [PMID:28649782]
52. Alpsoy, Aktan A and Dykhuizen, Emily C EC..  (2018)  Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes..  The Journal of biological chemistry,    (16):   [PMID:29374058]
53. Thomas R Burkard,Melanie Planyavsky,Ines Kaupe,Florian P Breitwieser,Tilmann Bürckstümmer,Keiryn L Bennett,Giulio Superti-Furga,Jacques Colinge.  (2011-01-29)  Initial characterization of the human central proteome..  BMC systems biology,  5  (17-17).  [PMID:21269460]

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