brincidofovir , DNA polymerase inhibitor, CAS No.444805-28-1, DNA polymerase inhibitor

Item Number
B608219
Grouped product items
SKUSizeAvailabilityPrice Qty
B608219-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
B608219-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,001.90

Basic Description

Synonyms3-(hexadecyloxy)propyl hydrogen ((((S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonate | 3-((2S)-2-{[(3-Hexadecyloxypropoxy)(hydroxyphosphoryl)]methoxy}-3-hydroxypropyl)-6-amino-3-hydropyrimidin-2-one | Cidofovir prodrug |
Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionDNA polymerase inhibitor

Product Properties

ALogP4.9

Associated Targets(Human)

HFF (3142 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Liver (3974 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Cavia porcellus (23802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human betaherpesvirus 5 (5122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cowpox virus (428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vaccinia virus (4609 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Murid betaherpesvirus 1 (143 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BSC-1 (357 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Caviid betaherpesvirus 2 (56 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ectromelia virus Moscow (12 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name [(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethyl-(3-hexadecoxypropoxy)phosphinic acid
INCHI InChI=1S/C27H52N3O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19-35-20-16-21-37-38(33,34)24-36-25(23-31)22-30-18-17-26(28)29-27(30)32/h17-18,25,31H,2-16,19-24H2,1H3,(H,33,34)(H2,28,29,32)/t25-/m0/s1
InChi Key WXJFKKQWPMNTIM-VWLOTQADSA-N
Canonical SMILES CCCCCCCCCCCCCCCCOCCCOP(=O)(COC(CN1C=CC(=NC1=O)N)CO)O
Isomeric SMILES CCCCCCCCCCCCCCCCOCCCOP(=O)(CO[C@@H](CN1C=CC(=NC1=O)N)CO)O
Alternate CAS 444805-28-1
PubChem CID 483477
MeSH Entry Terms brincidofovir;cidofovir hexadecyloxypropyl ester;CMX 001;CMX-001;CMX001;HDP-CDV;hexadecyloxypropyl cidofovir;Tembexa
Molecular Weight 561.7

Certificates

Certificate of Analysis(COA)

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Related Documents

References

1. Tichý T, Andrei G, Dračínský M, Holý A, Balzarini J, Snoeck R, Krečmerová M.  (2011)  New prodrugs of Adefovir and Cidofovir..  Bioorg Med Chem,  19  (11): (3527-39).  [PMID:21565516]
2. Hussien MA, Abdelaziz AEM.  (2020)  Molecular docking suggests repurposing of brincidofovir as a potential drug targeting SARS-CoV-2 ACE2 receptor and main protease..  Netw Model Anal Health Inform Bioinform,  (1): (56).  [PMID:32834922]
3. Chan SY, Prockop SE, Boulad F, Papanicolaou GA, Lee YJ.  (2020)  Rapid Virologic Response to Brincidofovir in Children with Disseminated Adenovirus Infection..  Infect Chemother,  71  (13): (1755-70).  [PMID:32869551]
4. Hutson CL, Kondas AV, Mauldin MR, Doty JB, Grossi IM, Morgan CN, Ostergaard SD, Hughes CM, Nakazawa Y, Kling C et al..  (2021)  Pharmacokinetics and Efficacy of a Potential Smallpox Therapeutic, Brincidofovir, in a Lethal Monkeypox Virus Animal Model..  mSphere,  (1): (1755-70).  [PMID:33536322]
5. Richardson BE.  (2021)  Initial Experience Treating HPV-Related Laryngeal Diseases with Oral Brincidofovir: A Pilot Study..  Ann Otol Rhinol Laryngol,  71  (13): (34894211007227).  [PMID:33834883]

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