Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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B129826-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $39.90 | |
B129826-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $142.90 | |
B129826-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $199.90 | |
B129826-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $349.90 | |
B129826-1g | 1g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $979.90 | |
B129826-5g | 5g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $10,461.90 |
Potent, selective, non-competitive and reversible carbonic anhydrase II inhibitor
Synonyms | Azopt | Brinzolamide | AL-4862 | (4R)-4-(ethylamino)-2-(3-methoxypropy1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Brinzolamide is a carbonic anhydrase II inhibitor used to lower intraocular pressure.Potent, selective, non-competitive and reversible carbonic anhydrase II inhibitor (IC 50 = 2 nM). Decreases aqueous humor secretion. Increases blood flow to the optic ner |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of carbonic anhydrase 1;Inhibitor of carbonic anhydrase 12;Inhibitor of carbonic anhydrase 14;Inhibitor of carbonic anhydrase 7 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description |
Brinzolamide (AL-4862) is a selective carbonic anhydrase II inhibitor with anIC50 value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide can be used in glaucoma disease research
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IUPAC Name | (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide |
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INCHI | InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1 |
InChi Key | HCRKCZRJWPKOAR-JTQLQIEISA-N |
Canonical SMILES | CCNC1CN(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)CCCOC |
Isomeric SMILES | CCN[C@H]1CN(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)CCCOC |
WGK Germany | 3 |
RTECS | XJ9095055 |
Alternate CAS | 138890-62-7 |
PubChem CID | 68844 |
MeSH Entry Terms | (R)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-E)-1,2-thiazine-6-sulfonamide 1,1-dioxide;Azopt;brinzolamide |
Molecular Weight | 383.51 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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H2420437 | Certificate of Analysis | Aug 01, 2024 | B129826 |
H2420438 | Certificate of Analysis | Aug 01, 2024 | B129826 |
H2420440 | Certificate of Analysis | Aug 01, 2024 | B129826 |
H2420451 | Certificate of Analysis | Aug 01, 2024 | B129826 |
H2420452 | Certificate of Analysis | Aug 01, 2024 | B129826 |
I2404176 | Certificate of Analysis | Aug 01, 2024 | B129826 |
K2329136 | Certificate of Analysis | Dec 07, 2023 | B129826 |
L2129040 | Certificate of Analysis | Oct 19, 2023 | B129826 |
L2129041 | Certificate of Analysis | Oct 19, 2023 | B129826 |
E1520131 | Certificate of Analysis | Dec 07, 2022 | B129826 |
Solubility | DMSO: ≥10 mg/mL |
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Sensitivity | Moisture & Heat sensitive |
Melt Point(°C) | 132 °C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled H302+H332:Harmful if swallowed or if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. |
WGK Germany | 3 |
RTECS | XJ9095055 |
Merck Index | 1376 |