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BRL 44408 MALEATE - 98%, high purity , CAS No.118343-19-4, Antagonist of α 2A-adrenoceptor;Antagonist of α 2B-adrenoceptor;Antagonist of α 2C-adrenoceptor

Moligand™

≥98%

CAS#: 118343-19-4
Formula: C₁₃H₁₇N₃C₄H₄O₄
Molecular Weight: 331.37
PubChem CID: 121850

Item Number

B335093

Grouped product items
SKU	Size	Availability	Price	Qty
B335093-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$269.90
B335093-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$459.90

a selective α2A-AR antagonist

View related series

α2A-adrenoceptor Antagonist α2B-adrenoceptor Antagonist α2C-adrenoceptor Antagonist

Basic Description

Synonyms	UNII-ZET7B198W2 \| 2-(2H-(1-methyl-1,3-dihydroisoindole)methyl)-4,5-dihydroimidazole \| BRL 44408 \| Q4836377 \| DTXSID30922665 \| GTPL525 \| PDSP2_001727 \| CAS_121850 \| NSC_121850 \| 2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-1-methyl-2,3-dihydro-1H-isoindole \| L
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of α 2A-adrenoceptor;Antagonist of α 2B-adrenoceptor;Antagonist of α 2C-adrenoceptor
Product Description	BRL 44408 maleate is a selective α2A-AR antagonist. Adrenoreceptors, or adrenergic receptors are G protein-coupled proteins involved in a variety of sympathetic activities. In general, α2A-AR has been associated with regulation of neurotransmitter release from sympathetic nerves. BRL 44408 maleate studies show associated increases hippocampal noradrenaline release following systemic administration.

Associated Targets(Human)

ADRA2B Tclin Alpha-2B adrenergic receptor (1 Activities)

Discover Target: ADRA2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2C Tclin Alpha-2C adrenergic receptor (1 Activities)

Discover Target: ADRA2C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2A Tclin Alpha-2A adrenergic receptor (0 Activities)

Discover Target: ADRA2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RGS12 Tbio Regulator of G-protein signaling 12 (93 Activities)

Discover Target: RGS12

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)

Discover Target: RGS4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	2-(4,5-dihydro-1H-imidazol-2-ylmethyl)-1-methyl-1,3-dihydroisoindole
INCHI	InChI=1S/C13H17N3/c1-10-12-5-3-2-4-11(12)8-16(10)9-13-14-6-7-15-13/h2-5,10H,6-9H2,1H3,(H,14,15)
InChi Key	SGOFAUSEYBZKDQ-UHFFFAOYSA-N
Canonical SMILES	CC1N(CC2=NCCN2)CC3=CC=CC=C31.OC(/C=C\C(O)=O)=O
Isomeric SMILES	CC1C2=CC=CC=C2CN1CC3=NCCN3
WGK Germany	3
Alternate CAS	681806-46-2
PubChem CID	121850
Molecular Weight	331.37

PubChem CID

Wikipedia

ChEMBL Ligand

CAS Registry No.

GPCRdb Ligand

Certificates

Certificate of Analysis(COA)

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6 results found

Lot Number	Certificate Type	Date	Item
H2423407	Certificate of Analysis	Aug 15, 2024	B335093
H2423410	Certificate of Analysis	Aug 15, 2024	B335093
H2423411	Certificate of Analysis	Aug 15, 2024	B335093
H2423413	Certificate of Analysis	Aug 15, 2024	B335093
H2205784	Certificate of Analysis	Jun 20, 2022	B335093
H2205786	Certificate of Analysis	Jun 20, 2022	B335093

Solubility

Soluble in water (15 mg/mL).

Refractive Index

n20D1.66 (Predicted)

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BRL 44408 MALEATE - 98%, high purity , CAS No.118343-19-4, Antagonist of α 2A-adrenoceptor;Antagonist of α 2B-adrenoceptor;Antagonist of α 2C-adrenoceptor

Basic Description

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

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Solution Calculators

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