BRL-54443 - 10mM in DMSO, high purity , CAS No.57477-39-1(DMSO)

Item Number

B409219

• Specifications & Purity: Moligand™, 10mM in DMSO
• Biochemical and Physiological Mechanisms: BRL 54443 is a 5-HT1E and 5-HT1F receptor agonist with pK_i of 8.7 and 9.25, respectively, with a weak binding affinity for 5-HT1A, 5-HT1B, 5-HT1D receptors.
• Storage Temp: Store at -80°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™

Product Description

Information

BRL 54443 is a5-HT1Eand5-HT1Freceptor agonist withpKiof 8.7 and 9.25, respectively, with a weak binding affinity for 5-HT1A, 5-HT1B, 5-HT1D receptors.
In vitro

BRL 54443 has also measurable affinity for the 5-HT_2A receptor. BRL 54443 induces contraction with a −logEC50 of 6.52. Contraction caused by BRL 54443 is likely mediated through stimulation of 5-HT5-HT_2A receptors.

In vivo

BRL 54443 induces an immediate dose-dependent maximal intragastric volume increase vs. saline.
Cell Data

cell lines：Renca or 786-O cells, mouse endothelial cells and splenic CD11b⁺/c^-myeloid cells, HUVECs

Concentrations：

Incubation Time：

Powder Purity:≥99%