Basic Description

Synonyms	Brodimoprim \| 56518-41-3 \| Brodimoprima \| Brodimoprime \| Brodimoprimum \| Ro 10-5970 \| 5-(4-bromo-3,5-dimethoxybenzyl)pyrimidine-2,4-diamine \| Brodimoprim [INN] \| 2,4-Diamino-5-(4-bromo-3,5-dimethoxybenzyl)pyrimidine \| Ro 105970 \| V1YC7T6LLI \| 5-[(4-bromo-3,5-dimethoxyphenyl)me
Specifications & Purity	Moligand™
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™

Associated Targets(Human)

DHFR Tclin Dihydrofolate reductase (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DHFR Tclin Dihydrofolate reductase (3072 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Escherichia coli (133304 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mycobacterium leprae (477 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IUPAC Name	5-[(4-bromo-3,5-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine
INCHI	InChI=1S/C13H15BrN4O2/c1-19-9-4-7(5-10(20-2)11(9)14)3-8-6-17-13(16)18-12(8)15/h4-6H,3H2,1-2H3,(H4,15,16,17,18)
InChi Key	BFCRRLMMHNLSCP-UHFFFAOYSA-N
Canonical SMILES	COC1=CC(=CC(=C1Br)OC)CC2=CN=C(N=C2N)N
Isomeric SMILES	COC1=CC(=CC(=C1Br)OC)CC2=CN=C(N=C2N)N
PubChem CID	68760
Molecular Weight	339.19

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Melt Point(°C)	227-229° C

1. Then RL, Böhni E, Angehrn P, Plozza-Nottebrock H, Stoeckel K. (1982) New analogs of trimethoprim.. Rev Infect Dis, 4 (2): (372-7). [PMID:7051237]
2. Arndt J, Riebenfeld D, Maier H, Weidauer H. (1994) Therapeutic efficacy and tolerability of brodimoprim in comparison with doxycycline in acute sinusitis in adults.. J Chemother, 6 (5): (322-7). [PMID:7861197]
3. Cosmi EV, Cantini L, Monici Preti PA, Di Renzo GC, Abate F, Balsotti G, Carlomagno G, Cirese E, Indraccolo R, La Sala GB et al.. (1996) Efficacy and tolerability of brodimoprim at two different dosage schedules in the treatment of acute uncomplicated bacterial cystitis: comparative study vs. pefloxacin.. Eur J Obstet Gynecol Reprod Biol, 64 (2): (207-11). [PMID:8820004]

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