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B433517-500ml

500ml

Available within 8-12 weeks(?)

$321.90

Basic Description

Synonyms	Bromochloromethane \| 74-97-5 \| bromo(chloro)methane \| CHLOROBROMOMETHANE \| Methane, bromochloro- \| Methylene chlorobromide \| Chloromethyl bromide \| Halon 1011 \| Fluorocarbon 1011 \| Monochloromonobromomethane \| Mil-B-4394-B \| Bromo-Chloro-Methane \| Mono-chloro-mono-bromo-methane \|
Specifications & Purity	≥99.5%, stabilized with 100 ppm BHT
Product Description	General Description Bromochloromethane is a by-product of disinfection of water by chlorination. It has potential antimethanogenic activity and reduces rumen methane production in dairy goats. Application Bromochloromethane was used in the synthesis and characterization of poly(methylene dicarboxylates).

Associated Targets(Human)

RORC Tchem Nuclear receptor ROR-gamma (0 Activities)

Discover Target: RORC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (0 Activities)

Discover Target: APEX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Lymphoblastoid cell (5959 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Aspergillus nidulans (364 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	bromo(chloro)methane
INCHI	InChI=1S/CH2BrCl/c2-1-3/h1H2
InChi Key	JPOXNPPZZKNXOV-UHFFFAOYSA-N
Canonical SMILES	C(Cl)Br
Isomeric SMILES	C(Cl)Br
WGK Germany	2
RTECS	PA5250000
PubChem CID	6333
UN Number	1887
Packing Group	III
Molecular Weight	129.38
Beilstein	1730801

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Refractive Index	1.482
Flash Point(°F)	312.8 °F
Flash Point(°C)	156 °C
Boil Point(°C)	68°C
Melt Point(°C)	-88°C

Safety and Hazards(GHS)

Pictogram(s)	GHS05, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H335:May cause respiratory irritation H314:Causes severe skin burns and eye damage H318:Causes serious eye damage H332:Harmful if inhaled H420:Harms public health and the environment by destroying ozone in the upper atmosphere
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P363:Wash contaminated clothing before reuse. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P502:Refer to manufacturer or supplier for information on recovery or recycling P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P332+P317:If skin irritation occurs: Get medical help. P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell.
WGK Germany	2
RTECS	PA5250000
Class	6.1

Citations of This Product

1. Meng-Meng Lun, Chang-Yuan Su, Jie Li, Qiang-Qiang Jia, Hai-Feng Lu, Da-Wei Fu, Yi Zhang, Zhi-Xu Zhang. (2023) Introducing Ferroelasticity into 1D Hybrid Lead Halide Semiconductor by Halogen Substitution Strategy. Small, 19 (49): (2303127). [PMID:37625019]
2. Meng-Meng Lun, Fo-Ling Zhou, Da-Wei Fu, Qiong Ye. (2022) Multi-functional hybrid perovskites with triple-channel switches and optical properties. Journal of Materials Chemistry C, 10 (31): (11371-11378). [PMID:]

References

1. D Pankow,M Weise,P Hoffmann. (1992-01-01) Effect of isoniazid or phenobarbital pretreatment on the metabolism of dihalomethanes to carbon monoxide.. Polish journal of occupational medicine and environmental health, 5 ((3)): (245-250). [PMID:1490123]
2. M L Gargas,M E Andersen. (1989-06-15) Determining kinetic constants of chlorinated ethane metabolism in the rat from rates of exhalation.. Toxicology and applied pharmacology, 99 ((2)): (344-353). [PMID:2734795]
3. J N McDougal,G W Jepson,H J Clewell,M G MacNaughton,M E Andersen. (1986-09-15) A physiological pharmacokinetic model for dermal absorption of vapors in the rat.. Toxicology and applied pharmacology, 85 ((2)): (286-294). [PMID:3764915]
4. J N McDougal,G W Jepson,H J Clewell,M E Andersen. (1985-06-15) Dermal absorption of dihalomethane vapors.. Toxicology and applied pharmacology, 79 ((1)): (150-158). [PMID:4049402]
5. R Thier,J B Taylor,S E Pemble,W G Humphreys,M Persmark,B Ketterer,F P Guengerich. (1993-09-15) Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes.. Proceedings of the National Academy of Sciences of the United States of America, 90 ((18)): (8576-8580). [PMID:8378332]
6. G W Jepson,J N McDougal. (1997-06-01) Physiologically based modeling of nonsteady state dermal absorption of halogenated methanes from an aqueous solution.. Toxicology and applied pharmacology, 144 ((2)): (315-324). [PMID:9194415]
7. G W Jepson,J N McDougal. (1999-06-03) Predicting vehicle effects on the dermal absorption of halogenated methanes using physiologically based modeling.. Toxicological sciences : an official journal of the Society of Toxicology, 48 ((2)): (180-188). [PMID:10353309]
8. Stuart E Denman,Nigel W Tomkins,Christopher S McSweeney. (2007-10-24) Quantitation and diversity analysis of ruminal methanogenic populations in response to the antimethanogenic compound bromochloromethane.. FEMS microbiology ecology, 62 ((3)): (313-322). [PMID:17949432]
9. Gunjan Goel,Harinder P S Makkar,Klaus Becker. (2009-02-27) Inhibition of methanogens by bromochloromethane: effects on microbial communities and rumen fermentation using batch and continuous fermentations.. The British journal of nutrition, 101 ((10)): (1484-1492). [PMID:19243639]
10. W S Cuello,T A T Janes,J M Jessee,M A Venecek,M E Sawyer,C R Eklund,M V Evans. (2012-06-22) Physiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in Rats.. Journal of toxicology, 2012 (629781-629781). [PMID:22719758]
11. Leticia Abecia,Gonzalo Martínez-Fernandez,Kate Waddams,Antonio Ignacio Martín-García,Eric Pinloche,Christopher J Creevey,Stuart Edward Denman,Charles James Newbold,David R Yáñez-Ruiz. (2018-10-26) Analysis of the Rumen Microbiome and Metabolome to Study the Effect of an Antimethanogenic Treatment Applied in Early Life of Kid Goats.. Frontiers in microbiology, 9 (2227-2227). [PMID:30356690]
12. M L Gargas,M E Andersen,H J Clewell. (1986-12-01) A physiologically based simulation approach for determining metabolic constants from gas uptake data.. Toxicology and applied pharmacology, 86 ((3)): (341-352). [PMID:3787629]
13. S Osterman-Golkar,S Hussain,S Walles,B Anderstam,K Sigvardsson. (1983-08-15) Chemical reactivity and mutagenicity of some dihalomethanes.. Chemico-biological interactions, 46 ((1)): (121-130). [PMID:6352069]
14. Tamas Rozgonyi,Leticia Gonzalez. (2006-08-25) On the location of conical intersections in CH2BrCl using MS-CASPT2 methods.. The journal of physical chemistry. A, 110 ((34)): (10251-10259). [PMID:16928115]
15. Juan Li,Jie Yang,Yuxiang Mo,K C Lau,X M Qian,Y Song,Jianbo Liu,C Y Ng. (2007-05-19) Combined vacuum ultraviolet laser and synchrotron pulsed field ionization study of CH2BrCl.. The Journal of chemical physics, 126 ((18)): (184304-184304). [PMID:17508800]
16. Makoto Mitsumori,Takumi Shinkai,Akio Takenaka,Osamu Enishi,Koji Higuchi,Yosuke Kobayashi,Itoko Nonaka,Narito Asanuma,Stuart E Denman,Christopher S McSweeney. (2011-11-09) Responses in digestion, rumen fermentation and microbial populations to inhibition of methane formation by a halogenated methane analogue.. The British journal of nutrition, 108 ((3)): (482-491). [PMID:22059589]
17. L Abecia,P G Toral,A I Martín-García,G Martínez,N W Tomkins,E Molina-Alcaide,C J Newbold,D R Yáñez-Ruiz. (2012-03-31) Effect of bromochloromethane on methane emission, rumen fermentation pattern, milk yield, and fatty acid profile in lactating dairy goats.. Journal of dairy science, 95 ((4)): (2027-2036). [PMID:22459848]
18. Meng-Meng Lun, Chang-Yuan Su, Jie Li, Qiang-Qiang Jia, Hai-Feng Lu, Da-Wei Fu, Yi Zhang, Zhi-Xu Zhang. (2023) Introducing Ferroelasticity into 1D Hybrid Lead Halide Semiconductor by Halogen Substitution Strategy. Small, 19 (49): (2303127). [PMID:37625019]
19. Meng-Meng Lun, Fo-Ling Zhou, Da-Wei Fu, Qiong Ye. (2022) Multi-functional hybrid perovskites with triple-channel switches and optical properties. Journal of Materials Chemistry C, 10 (31): (11371-11378). [PMID:]

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Bromochloromethane - contains 100 ppm BHT as inhibitor, ≥99.5%, high purity , CAS No.74-97-5