Brusatol (NSC 172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent[1]. Brusatol increases cellular apoptosis。
1.Wang Zhi-shun, Shu Bo, Han Qi, Li Guo-hao, Guo Yong-lian. (2023) Effects of grape seed-derived proanthocyanidin B2 pretreatment on oxidative stress, endoplasmic reticulum stress and apoptosis of renal tubular epithelial cells in renal ischemia–reperfusion injury model of mice. INTERNATIONAL UROLOGY AND NEPHROLOGY, (1-12). [PMID:36935438][10.1007/s11255-023-03494-4]
2.Na Wei, Tan Lu, Libin Yang, Yonghan Dong, Xiaotan Liu. (2021) Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway. FEBS Open Bio, 11 (8):(2118-2126). [PMID:34048148][10.1002/2211-5463.13203]
References
1.Wang Zhi-shun, Shu Bo, Han Qi, Li Guo-hao, Guo Yong-lian. (2023) Effects of grape seed-derived proanthocyanidin B2 pretreatment on oxidative stress, endoplasmic reticulum stress and apoptosis of renal tubular epithelial cells in renal ischemia–reperfusion injury model of mice. INTERNATIONAL UROLOGY AND NEPHROLOGY, (1-12). [PMID:36935438][10.1007/s11255-023-03494-4]
2.Na Wei, Tan Lu, Libin Yang, Yonghan Dong, Xiaotan Liu. (2021) Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway. FEBS Open Bio, 11 (8):(2118-2126). [PMID:34048148][10.1002/2211-5463.13203]
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