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BTT 3033 - ≥98%(HPLC), high purity , CAS No.1259028-99-3, Inhibitor of integrin α2β1

Moligand™

≥98%(HPLC)

CAS#: 1259028-99-3
Formula: C₂₃H₂₀FN₅O₃S
Molecular Weight: 465.5
MDL number: MFCD28166480
PubChem CID: 49841251

Item Number

B288291

Grouped product items
SKU	Size	Availability	Price
B288291-5mg	5mg	In stock	$147.90
B288291-10mg	10mg	In stock	$246.90
B288291-25mg	25mg	In stock	$494.90
B288291-50mg	50mg	In stock	$791.90
B288291-100mg	100mg	In stock	$1,425.90

Selective inhibitor of integrin α2β1

View related series

Cytoskeleton Integrin integrin α2β1 Inhibitor

Basic Description

Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Selective inhibitor of integrinα2β1(EC50= 130 nM forα2β1binding to collagen I). Binds to theα2I domain. Exhibits selectivity forα2β1over integrinsα3β1,α4β1,α5β1andαv. Inhibits platelet aggregation to collagen I coated capillaries under flow. Also inhibits
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of integrin α2β1
Product Description	Product description BTT-3033 is an orally active conformation-selective inhibitor of α2β1 (EC50: 130 nM) by binding to the α2I domain. BTT-3033 inhibits platelet binding to collagen Ⅰ and cell proliferation, and induces cell apoptosis. BTT-3033 can be used in the research of prostate cancer, inflammation and cardiovascular disease.

Associated Targets(Human)

ITGA2 Tbio Integrin alpha-2 (0 Activities)

Discover Target: ITGA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ITGB1 Tclin Integrin beta-1 (0 Activities)

Discover Target: ITGB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ITGB1 Tclin Integrin alpha2/beta1 (69 Activities)

Discover Target: ITGB1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1-[4-[[1-(4-fluorophenyl)pyrazol-4-yl]sulfonyl-methylamino]phenyl]-3-phenylurea
INCHI	InChI=1S/C23H20FN5O3S/c1-28(33(31,32)22-15-25-29(16-22)21-11-7-17(24)8-12-21)20-13-9-19(10-14-20)27-23(30)26-18-5-3-2-4-6-18/h2-16H,1H3,(H2,26,27,30)
InChi Key	NSLIQOPYDUKWTA-UHFFFAOYSA-N
Canonical SMILES	CN(C1=CC=C(C=C1)NC(=O)NC2=CC=CC=C2)S(=O)(=O)C3=CN(N=C3)C4=CC=C(C=C4)F
Isomeric SMILES	CN(C1=CC=C(C=C1)NC(=O)NC2=CC=CC=C2)S(=O)(=O)C3=CN(N=C3)C4=CC=C(C=C4)F
PubChem CID	49841251
Molecular Weight	465.5

Certificates

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10 results found

Lot Number	Certificate Type	Date	Item
F23141009	Certificate of Analysis	May 30, 2023	B288291
F23141010	Certificate of Analysis	May 30, 2023	B288291
F23141024	Certificate of Analysis	May 30, 2023	B288291
F23141026	Certificate of Analysis	May 30, 2023	B288291
F23141085	Certificate of Analysis	May 30, 2023	B288291
F23141119	Certificate of Analysis	May 30, 2023	B288291
F2314885	Certificate of Analysis	May 30, 2023	B288291
F2314931	Certificate of Analysis	May 30, 2023	B288291
F2314987	Certificate of Analysis	May 30, 2023	B288291
F2314989	Certificate of Analysis	May 30, 2023	B288291

References

1. Nissinen L, Koivunen J, Käpylä J, Salmela M, Nieminen J, Jokinen J, Sipilä K, Pihlavisto M, Pentikäinen OT, Marjamäki A et al.. (2012) Novel α2β1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation.. J Biol Chem, 287 (53): (44694-702). [PMID:23132859] [10.1021/op500134e]

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