Na + /K + -ATPase inhibitor. Potent steroid receptor coactivators SRC-3 and SRC-1 inhibitor. Induces cell differentiation and apoptosis. Activates AP-1 via JNK. Shows antitumor effects in vivo.
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
Product Description
Bufalin is a C-24 steroid with an α-pyrone ring positioned at C-17. It is present in the venom glands and skin of toad, Venenum Bufonis.Bufalin is a cardiotonic steroid[5] and is digoxin-like component of Chan Su. Bufalin has been used: • to test its effect on invasion and activation of nuclear factor kappa- B (NF-κB) cells and tumor necrosis factor-α (TNF-α) stimulated rheumatoid arthritis fibroblast-like synoviocytes (RAFLSs) • as a nuclear receptor coactivator 3 (NCOA3) inhibitor in chondrocytes • to test its anti-metastasis effect in lung cancer cells (NCI-H460) resistant to gefitinib
