Bufalin - 10mM in DMSO, high purity , CAS No.465-21-4

Item Number

B424094

• Synonyms: bufalin | 465-21-4 | CHEBI:517248 | 3-beta,14-Dihydroxy-5-beta-bufa-20,22-dienolide | 3,14-Dihydroxy-bufa-20,22-dienolide | U549S98QLW | 5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one | 3bet
• Specifications & Purity: 10mM in DMSO
• Biochemical and Physiological Mechanisms: Na + /K + -ATPase inhibitor. Potent steroid receptor coactivators SRC-3 and SRC-1 inhibitor. Induces cell differentiation and apoptosis. Activates AP-1 via JNK. Shows antitumor effects in vivo.
• Storage Temp: Store at -80°C
• Shipped In: Ice chest + Ice pads

Product Description

Bufalin is a C-24 steroid with an α-pyrone ring positioned at C-17. It is present in the venom glands and skin of toad, Venenum Bufonis.Bufalin is a cardiotonic steroid[5] and is digoxin-like component of Chan Su.
Bufalin has been used:
• to test its effect on invasion and activation of nuclear factor kappa- B (NF-κB) cells and tumor necrosis factor-α (TNF-α) stimulated rheumatoid arthritis fibroblast-like synoviocytes (RAFLSs)
• as a nuclear receptor coactivator 3 (NCOA3) inhibitor in chondrocytes
• to test its anti-metastasis effect in lung cancer cells (NCI-H460) resistant to gefitinib