Bufexamac is a specific inhibitor of HDAC6 and HDAC10. Treatment of peripheral blood mononuclear cells with bufexamac inhibits the secretion of IFN-α. Bufexamac is a frequent and relevant contact sensitizer.HDAC6 and HDAC10 inhibitor. NSAID. COX inhibitor
Shipped In
Normal
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of histone deacetylase 10;Inhibitor of histone deacetylase 6
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM. A HDAC6 and HDAC10 inhibitor.
Product Properties
ALogP
1.9
Associated Targets
CHD1Tbio Chromodomain-helicase-DNA-binding protein 1 0 Activities
1.Trommer H, Plätzer M, Raith K, Wohlrab W, Podhaisky HP, Neubert RH. (2003) Examinations of the antioxidative properties of the topically administered drug bufexamac reveal new insights into its mechanism of action.. J Pharm Pharmacol, 55 (10):(1379-88). [PMID:14607020]
2.Bantscheff M, Hopf C, Savitski MM, Dittmann A, Grandi P, Michon AM, Schlegl J, Abraham Y, Becher I, Bergamini G et al.. (2011) Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes.. Nat Biotechnol, 29 (3):(255-65). [PMID:21258344]
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