Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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B129942-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $9.90 | |
B129942-50mg | 50mg | In stock | $9.90 | |
B129942-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $17.90 | |
B129942-250mg | 250mg | In stock | $34.90 | |
B129942-1g | 1g | In stock | $114.90 | |
B129942-5g | 5g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $469.90 |
Potent, selective Na + /2Cl - /K + cotransporter inhibitor
Synonyms | BUMETANIDE [EP IMPURITY] | KBio1_000034 | BUMETANIDE [EP MONOGRAPH] | BENZOIC ACID, 3-(BUTYLAMINO)-4-PHENOXY-5-SULFAMOYL- | BPBio1_000168 | Lopac-B-3023 | MLS000028457 | Opera_ID_1734 | Prestwick1_000276 | 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Potent, selective Na + /2Cl - /K + cotransporter inhibitor. Shows 40-fold greater potency than furosemide ( Asc 314 ). Shows diuretic and anticonvulsant effects in vivo. |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | AGONIST, INHIBITOR |
Mechanism of action | Sodium-(potassium)-chloride cotransporter 2 inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Bumetanide |
ALogP | 2.8 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid |
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INCHI | InChI=1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,18,22,23) |
InChi Key | MAEIEVLCKWDQJH-UHFFFAOYSA-N |
Canonical SMILES | CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2 |
Isomeric SMILES | CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2 |
WGK Germany | 3 |
RTECS | DG4910000 |
PubChem CID | 2471 |
Molecular Weight | 364.42 |
DrugBank Ligand | DB00887 |
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CAS Registry No. | 28395-03-1 |
Wikipedia | Bumetanide |
ChEBI | CHEBI:3213 |
PubChem CID | 2471 |
ChEMBL Ligand | CHEMBL1072 |
PEP | bumetanide |
DrugCentral Ligand | 427 |
RCSB PDB Ligand | 82U |
GPCRdb Ligand | bumetanide |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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J2228292 | Certificate of Analysis | Aug 13, 2024 | B129942 |
J2228375 | Certificate of Analysis | Aug 12, 2024 | B129942 |
J2228289 | Certificate of Analysis | Aug 12, 2024 | B129942 |
E2415226 | Certificate of Analysis | Apr 23, 2024 | B129942 |
E2415227 | Certificate of Analysis | Apr 23, 2024 | B129942 |
E2415232 | Certificate of Analysis | Apr 23, 2024 | B129942 |
E2415237 | Certificate of Analysis | Apr 23, 2024 | B129942 |
E2415247 | Certificate of Analysis | Apr 23, 2024 | B129942 |
E2415248 | Certificate of Analysis | Apr 23, 2024 | B129942 |
E2415251 | Certificate of Analysis | Apr 23, 2024 | B129942 |
A2415082 | Certificate of Analysis | Dec 27, 2023 | B129942 |
A2415084 | Certificate of Analysis | Dec 27, 2023 | B129942 |
A2415083 | Certificate of Analysis | Dec 27, 2023 | B129942 |
A2415081 | Certificate of Analysis | Dec 27, 2023 | B129942 |
K2116213 | Certificate of Analysis | Sep 13, 2023 | B129942 |
K2116214 | Certificate of Analysis | Sep 13, 2023 | B129942 |
J2228293 | Certificate of Analysis | Jul 20, 2022 | B129942 |
F1430041 | Certificate of Analysis | Apr 14, 2022 | B129942 |
Solubility | DMSO 73 mg/mL Water <1 mg/mL Ethanol 36 mg/mL |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | DG4910000 |
1. Chunyan Chen, Ping Fan, Lirong Zhang, Kaige Xue, Jiaheng Hu, Juan Huang, Weitian Lu, Jin Xu, Shiye Xu, Guoping Qiu, Jianhua Ran, Shengwei Gan. (2023) Bumetanide Rescues Aquaporin-4 Depolarization via Suppressing β-Dystroglycan Cleavage and Provides Neuroprotection in Rat Retinal Ischemia-Reperfusion Injury. NEUROSCIENCE, 510 (95). [PMID:36493910] [10.1016/j.neuroscience.2022.11.033] |
2. Zhang DL, Sun YJ, Ma ML, Wang YJ, Lin H, Li RR, Liang ZL, Gao Y, Yang Z, He DF et al.. (2018) Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.. Elife, 7 (13): (1755-70). [PMID:29393851] [10.1021/op500134e] |
1. Lemonnier E, Villeneuve N, Sonie S, Serret S, Rosier A, Roue M, Brosset P, Viellard M, Bernoux D, Rondeau S et al.. (2017) Effects of bumetanide on neurobehavioral function in children and adolescents with autism spectrum disorders.. Transl Psychiatry, 7 (3): (e1056). [PMID:28291262] [10.1021/op500134e] |
2. Kharod SC, Kang SK, Kadam SD. (2019) Off-Label Use of Bumetanide for Brain Disorders: An Overview.. Front Neurosci, 13 (13): (310). [PMID:31068771] [10.1021/op500134e] |
3. Chunyan Chen, Ping Fan, Lirong Zhang, Kaige Xue, Jiaheng Hu, Juan Huang, Weitian Lu, Jin Xu, Shiye Xu, Guoping Qiu, Jianhua Ran, Shengwei Gan. (2023) Bumetanide Rescues Aquaporin-4 Depolarization via Suppressing β-Dystroglycan Cleavage and Provides Neuroprotection in Rat Retinal Ischemia-Reperfusion Injury. NEUROSCIENCE, 510 (95). [PMID:36493910] [10.1016/j.neuroscience.2022.11.033] |
4. Zhang DL, Sun YJ, Ma ML, Wang YJ, Lin H, Li RR, Liang ZL, Gao Y, Yang Z, He DF et al.. (2018) Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.. Elife, 7 (13): (1755-70). [PMID:29393851] [10.1021/op500134e] |